Christopher M. Mapes
Johnson & Johnson
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Publication
Featured researches published by Christopher M. Mapes.
Journal of Organic Chemistry | 2010
Christopher M. Mapes; Neelakandha S. Mani; Xiaohu Deng; Chennagiri R. Pandit; Kelly J. Mcclure; Marna C. W. Pippel; Clark A. Sehon; Laurent Gomez; Shirin Shinde; J. Guy Breitenbucher; Todd K. Jones
We describe a practical and scalable route to compound (Z)-1, a selective CCK1 receptor antagonist. Notable features of this concise route are (1) a regioselective construction of the pyrazole core through the reaction of an aryl hydrazine and an elaborated acetylenic ketone, (2) a Tf2O/pyridine mediated Z-selective dehydration of an α-hydroxyester, and (3) a stereoselective hydrolysis. The sequence is high-yielding and amenable for large-scale synthesis.
Archive | 2000
Robert Ardecky; Marcus F. Boehm; Amy L. Faulkner; Lawrence G. Hamann; Todd K. Jones; Christopher M. Mapes; Pierre-Yves Michellys; John S. Tyhonas; Anthony W. Thompson; Jyun-Hung Chen
Journal of Organic Chemistry | 2007
Daniel J. Pippel; Christopher M. Mapes; Neelakandha S. Mani
Journal of Organic Chemistry | 2006
Neelakandha S. Mani; Christopher M. Mapes; Jiejun Wu; Xiaohu Deng; Todd K. Jones
Archive | 2009
Sergio Cesco-Cancian; Jeffrey S. Grimm; Neelakandha S. Mani; Christopher M. Mapes; David C. Palmer; Daniel J. Pippel; Tong Xiao; Diego Broggini; Susanne Lochner
Archive | 2004
Christopher M. Mapes; Donald S. Karanewsky; Anthony W. Thompson; Pierrre Michellys; Daniel Ruppar; Jyun-Hung Chen
Archive | 2002
Michael Gregory Bell; Timothy Alan Grese; Douglas Linn Gernett; Nathan Yumibe; Marcus F. Boehm; Pierre-Yves Michellys; Robert Ardecky; Christopher M. Mapes; Jyun-Hung Chen; John S. Tyhonas; Lawrence G. Hamann
Archive | 2004
Pierre Michellys; Jyun-Hung Chen; Christopher M. Mapes; Daniel Ruppar; Donald S. Karanewsky; Anthony W. Thompson
Archive | 2013
Sergio Cesco-Cancian; セルジオ・セスコ−カンシアン; Jeffrey S. Grimm; ジエフリー・エス・グリム; S Mani Neelakandha; ニーラカンダ・エス・マニ; Christopher M. Mapes; クリストフアー・エム・メイプス; C Palmer David; デイビツド・シー・パルマー; Daniel J. Pippel; ダニエル・ジエイ・ピツペル; Tong Xiao; トン・シアオ; Broggini Diego; デイエゴ・ブロジーニ; Susanne Lochner; スザンヌ・ロフナー
Archive | 2009
Sergio Cesco-Cancian; Jeffrey S. Grimm; Neelakandha S. Mani; Christopher M. Mapes; David C. Palmer; Daniel J. Pippel; Tong Xiao; Diego Broggini; Susanne Lochner
