Christopher M. Mapes | Researchain

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Featured researches published by Christopher M. Mapes.

Journal of Organic Chemistry | 2010

Practical and Scalable Synthesis of a Selective CCK1 Receptor Antagonist

Christopher M. Mapes; Neelakandha S. Mani; Xiaohu Deng; Chennagiri R. Pandit; Kelly J. Mcclure; Marna C. W. Pippel; Clark A. Sehon; Laurent Gomez; Shirin Shinde; J. Guy Breitenbucher; Todd K. Jones

We describe a practical and scalable route to compound (Z)-1, a selective CCK1 receptor antagonist. Notable features of this concise route are (1) a regioselective construction of the pyrazole core through the reaction of an aryl hydrazine and an elaborated acetylenic ketone, (2) a Tf2O/pyridine mediated Z-selective dehydration of an α-hydroxyester, and (3) a stereoselective hydrolysis. The sequence is high-yielding and amenable for large-scale synthesis.

Archive | 2000

Rxr modulators with improved pharmacologic profile

Robert Ardecky; Marcus F. Boehm; Amy L. Faulkner; Lawrence G. Hamann; Todd K. Jones; Christopher M. Mapes; Pierre-Yves Michellys; John S. Tyhonas; Anthony W. Thompson; Jyun-Hung Chen

Journal of Organic Chemistry | 2007

Reactions between Weinreb Amides and 2-Magnesiated Oxazoles: A Simple and Efficient Preparation of 2-Acyl Oxazoles

Daniel J. Pippel; Christopher M. Mapes; Neelakandha S. Mani

Journal of Organic Chemistry | 2006

Stereoselective synthesis of Z-α-aryl-α,β-unsaturated esters

Neelakandha S. Mani; Christopher M. Mapes; Jiejun Wu; Xiaohu Deng; Todd K. Jones

Archive | 2009

Process for the preparation of benzoimidazol-2-yl pyrimidine derivatives

Sergio Cesco-Cancian; Jeffrey S. Grimm; Neelakandha S. Mani; Christopher M. Mapes; David C. Palmer; Daniel J. Pippel; Tong Xiao; Diego Broggini; Susanne Lochner

Archive | 2004

Benzoic and phenyl acetic acid derivatives as hnf-4 modulators

Christopher M. Mapes; Donald S. Karanewsky; Anthony W. Thompson; Pierrre Michellys; Daniel Ruppar; Jyun-Hung Chen

Archive | 2002

Fluorinated trienes and their use as rxr modulators

Michael Gregory Bell; Timothy Alan Grese; Douglas Linn Gernett; Nathan Yumibe; Marcus F. Boehm; Pierre-Yves Michellys; Robert Ardecky; Christopher M. Mapes; Jyun-Hung Chen; John S. Tyhonas; Lawrence G. Hamann

Archive | 2004

HEPATOCYTE NUCLEAR FACTOR 4α MODULATOR COMPOUNDS

Pierre Michellys; Jyun-Hung Chen; Christopher M. Mapes; Daniel Ruppar; Donald S. Karanewsky; Anthony W. Thompson

Archive | 2013

Crystalline hemi-tartrate of [5-(4,6-dimethyl-1h-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-piperidin-4-yl)-propyl]-amine

Sergio Cesco-Cancian; セルジオ・セスコ−カンシアン; Jeffrey S. Grimm; ジエフリー・エス・グリム; S Mani Neelakandha; ニーラカンダ・エス・マニ; Christopher M. Mapes; クリストフアー・エム・メイプス; C Palmer David; デイビツド・シー・パルマー; Daniel J. Pippel; ダニエル・ジエイ・ピツペル; Tong Xiao; トン・シアオ; Broggini Diego; デイエゴ・ブロジーニ; Susanne Lochner; スザンヌ・ロフナー

Archive | 2009

Procédé de préparation de dérivés de benzoimidazol-2-yl-pyrimidine

Sergio Cesco-Cancian; Jeffrey S. Grimm; Neelakandha S. Mani; Christopher M. Mapes; David C. Palmer; Daniel J. Pippel; Tong Xiao; Diego Broggini; Susanne Lochner

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