Is this you? Create Your Porfile
Avatar

Chuangxing Guo

Purdue University

Network

Latest external collaboration on country level. Dive into details by clicking on the dots.

Explore More

Hotspot

Dive into the research topics where Chuangxing Guo is active.

Explore More

Publication

Featured researches published by Chuangxing Guo.

Tetrahedron Letters | 1998

The first synthesis of the aglycone of the potent anti-tumor steroidal saponin OSW-1 ☆

Chuangxing Guo; P. L. Fuchs

The protected aglycone (21e-β) of the potent anti-tumor agent OSW-1 (1) was synthesized in 9 steps from 5-androsten-3β-ol-17-one (10) in 55% overall yield. Key reactions involve ene installation of the side chain, regio and stereoselective dihydroxylation and diastereoselective reduction of the C16 ketone.

Bioorganic & Medicinal Chemistry Letters | 1999

On the relationship of OSW-1 to the cephalostatins.

Chuangxing Guo; Thomas G. LaCour; P. L. Fuchs

Antineoplastic bis-steroidal (cephalostatin-type) analogues of the saponin OSW-1 were produced from a dihydroaglycone of OSW-1. The key aglycone 6H was obtained from 5alpha-androstan-3beta-ol-17-one in 8 steps (38% yield). The SAR of the aglycones, intermediates, and hybrid analogues provide insights regarding the proposed common role of C22-oxocarbenium ions in the bioactivity of both OSW-1 and cephalostatins.

Journal of the American Chemical Society | 1998

Interphylal Product Splicing: The First Total Syntheses of Cephalostatin 1, the North Hemisphere of Ritterazine G, and the Highly Active Hybrid Analogue, Ritterostatin GN1N1

Thomas G. LaCour; Chuangxing Guo; Sudhakar Bhandaru; and Michael R. Boyd; P. L. Fuchs

Journal of the American Chemical Society | 1999

Synthesis of the North 1 Unit of the Cephalostatin Family from Hecogenin Acetate1

Seongkon Kim; Scott C. Sutton; Chuangxing Guo; Thomas G. LaCour; P. L. Fuchs

Journal of the American Chemical Society | 1996

An Efficient Protocol for the Synthesis of Unsymmetrical Pyrazines. Total Synthesis of Dihydrocephalostatin 11

Chuangxing Guo; Sudhakar Bhandaru; P. L. Fuchs; Michael R. Boyd

Organic Letters | 2000

Outer-ring stereochemical modulation of cytotoxicity in cephalostatins.

Thomas G. LaCour; Chuangxing Guo; Michael R. Boyd; P. L. Fuchs

Bioorganic & Medicinal Chemistry Letters | 1999

On topography and functionality in the B-D rings of cephalostatin cytotoxins.

Thomas G. LaCour; Chuangxing Guo; Sunghoon Ma; Jae Uk Jeong; Michael R. Boyd; Shikegi Matsunaga; Nobuhiro Fusetani; P. L. Fuchs

ChemInform | 2010

Cephalostatin Synthesis. Part 10. An Efficient Protocol for the Synthesis of Unsymmetrical Pyrazines. Total Synthesis of Dihydrocephalostatin 1

Chuangxing Guo; S. Bhandaru; P. L. Fuchs; Michael R. Boyd

ChemInform | 2010

Cephalostatin Support Studies. Part 12. The First Synthesis of the Aglycone of the Potent Antitumor Steroidal Saponin OSW-1.

Chuangxing Guo; P. L. Fuchs

ChemInform | 2010

Cephalostatin Synthesis. Part 13. Synthesis of the North 1 Unit of the Cephalostatin Family from Hecogenin Acetate.

Seongkon Kim; Scott C. Sutton; Chuangxing Guo; Thomas G. LaCour; P. L. Fuchs

Explore More

Collaboration

Dive into the Chuangxing Guo's collaboration.

Top Co-Authors
Avatar

P. L. Fuchs

Purdue University

View shared research outputs
Top Co-Authors
Avatar

Thomas G. LaCour

Purdue University

View shared research outputs
Top Co-Authors
Avatar

Michael R. Boyd

Purdue University

View shared research outputs
Top Co-Authors
Avatar

S. Bhandaru

Purdue University

View shared research outputs
Top Co-Authors
Avatar

Scott C. Sutton

Purdue University

View shared research outputs
Top Co-Authors
Avatar

Seongkon Kim

Purdue University

View shared research outputs
Top Co-Authors
Avatar

Jae Uk Jeong

Purdue University

View shared research outputs
Top Co-Authors
Avatar

Sunghoon Ma

Purdue University

View shared research outputs
Top Co-Authors
Avatar

Nobuhiro Fusetani

Hokkaido University

View shared research outputs
Explore More
Researchain Logo
Decentralizing Knowledge