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Featured researches published by Chun Chen Yu.


Clinical Transplantation | 2004

Impact of HCV infection on first cadaveric renal transplantation, a single center experience

Hsin-Hung Lin; Chiu-Ching Huang; Jeng Yi Huang; Chih-Wei Yang; Mai Szu Wu; Ji Tseng Fang; Chun Chen Yu; Yang Jen Chiang; Sheng Hsieh Chu

Abstract:  Background:  Controversy still persists regarding the impact of HCV infection on renal transplant recipients. This study aimed to evaluate the effect of anti‐HCV antibody status on patients and grafts of renal transplants at a single center.


Shock | 2012

Early Identification of Leptospirosis as an Ignored Cause of Multiple Organ Dysfunction Syndrome

Huang Yu Yang; Tzung Hai Yen; Chan Yu Lin; Yung Chang Chen; Min Jeng Pan; Chih Hsiung Lee; Chun Chen Yu; Mai Szu Wu; Shin Shu Wu; Cheng Hao Weng; Kwan Hsing Chen; Cheng Chieh Hung; Chih-Wei Yang

ABSTRACT Leptospirosis is the most common zoonosis in the world but remains underreported, owing to protean manifestations and ignorance about the disease among health care providers in Taiwan. From September 2000 to March 2006, surveillance of 455 patients with multiple organ dysfunction syndrome with unclear cause or clinical suspicion of leptospirosis was performed. Diagnosis was further confirmed by microscopic agglutination test or isolation of Leptospira. Cases were classified as excluded based on confirmed etiology other than leptospirosis or negative paired serologic test. Forty-two patients were confirmed as having leptospirosis, which accounted for 9.2% of total patients with multiple organ dysfunction syndrome. Forty-nine excluded cases were identified for a case-control analysis for clinical distinction. The most common presentations of leptospirosis were fever (97.6%), acute kidney injury (85.7%), and jaundice (61.9%). The leptospirosis group showed lower urine specific gravity (cutoff value, 1.0145) and enlarged kidney size (cutoff value, 11.05 cm) as compared with the excluded cases by multivariate logistics regression. Delayed antibiotic administration prolongs the duration of hospitalization (R2 = 0.486, P < 0.01). No mortality has been found in the leptospirosis group after initiation in 2003 of rapid immunoglobulin M serology assay that showed considerably high sensitivity and specificity. Leptospirosis accounts for a salient cause of multiple organ dysfunctions in Taiwan. Early awareness of leptospirosis by distinct presentations, followed by prompt antibiotics therapy, can dramatically save the patients. The easily performed rapid immunoglobulin M serology assay is suitable as a rapid screening test for the diagnosis of leptospirosis.


Nephrology Dialysis Transplantation | 1997

Poor pre-dialysis glycaemic control is a predictor of mortality in type II diabetic patients on maintenance haemodialysis.

Mai-Szu Wu; Chun Chen Yu; Chih-Wei Yang; C H Wu; J Y Haung; J J Hong; C Y Fan Chiang; Chiu-Ching Huang; M.-L. Leu


Journal of The American Society of Nephrology | 2000

Leptospira Outer Membrane Protein Activates NF-κB and Downstream Genes Expressed in Medullary Thick Ascending Limb Cells

Chih-Wei Yang; Mai Szu Wu; Ming-Jeng Pan; Jenn Jye Hong; Chun Chen Yu; Alain Vandewalle; Chiu-Ching Huang


Journal of Nephrology | 2005

Clinical distinction and evaluation of leptospirosis in Taiwan--a case-control study.

Huang Yu Yang; Po Yaur Hsu; Ming-Jeng Pan; Mai Szu Wu; Chih Hsiung Lee; Chun Chen Yu; Chen Chieh Hung; Chih-Wei Yang


Journal of Laboratory and Clinical Medicine | 2001

Mycophenolate mofetil reduces renal cortical inducible nitric oxide synthase mRNA expression and diminishes glomerulosclerosis in MRL/lpr mice.

Chun Chen Yu; Chih-Wei Yang; Mai Szu Wu; Yi Ching Ko; Chiung Tseng Huang; Jenn Jye Hong; Chiu-Ching Huang


Nephrology Dialysis Transplantation | 2006

Leptospiral membrane proteins stimulate pro-inflammatory chemokines secretion by renal tubule epithelial cells through toll-like receptor 2 and p38 mitogen activated protein kinase

Cheng Chieh Hung; Chiz Tzung Chang; Ya Chung Tian; Mai Szu Wu; Chun Chen Yu; Ming-Jeng Pan; Alain Vandewalle; Chih-Wei Yang


Peritoneal Dialysis International | 1997

Predialysis glycemic control is an independent predictor of clinical outcome in type II diabetics on continuous ambulatory peritoneal dialysis

Chun Chen Yu; Mai Szu Wu; Ching Herng Wu; Chih-Wei Yang; Jeng Yi Huang; Jenn Jye Hong; Chun Yi Fan Chiang; Mei Ling Leu; Chiu-Ching Huang


Peritoneal Dialysis International | 1999

Pre-dialysis glycemic control is an independent predictor of mortality in type II diabetic patients on continuous ambulatory peritoneal dialysis.

Mai Szu Wu; Chun Chen Yu; Ching Herng Wu; Jeng Yi Haung; Mei Lin Leu; Chiu-Ching Huang


Journal of Nephrology | 2006

Aristolochic acid-related nephropathy associated with the popular Chinese herb Xi Xin.

Huang Yu Yang; Ja-Liang Lin; Chen Kh; Chun Chen Yu; Po Yaur Hsu; Lin Cl

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Mai Szu Wu

Taipei Medical University Hospital

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Cheng Chieh Hung

National Taiwan University

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Ming-Jeng Pan

Central Taiwan University of Science and Technology

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Jenn Jye Hong

National Taiwan University

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