Chun-I Wang

Syndrome of idiopathic hyperlipemia, mild diabetes mellitus, and severe vascular damage.

Idiopathic hyperlipemia is characterized by milky or creamy appearance (lactescence) of the serum in the fasting state. This is caused by a very marked increase of the neutral fat content. Often but not always there is a concomitant considerable increase of serum cholesterol and phospholipids. By definition, primary hypercholesteremia differs from idiopathic hyperlipemia in the clear appearance of the serum and in normal content of neutral fat. Both abnormalities of lipid metabolism may be associated with xanthoma formation. Xanthoma diabeticorum was extensively studied many years ago.-

ISOTOPIC STUDIES OF PLASMA CHOLESTEROL OF ENDOGENOUS AND EXOGENOUS ORIGINS

This study was undertaken in order to compare the metabolic behavior of plasma cholesterol derived from the diet with that of cholesterol synthesized in vAvo from acetate (1). Cholesterol labeled with either isotopic carbon or hydrogen was administered orally to human subjects and the incorporation into plasma cholesterol was followed over an extended period. In certain instances, both endogenous and exogenous cholesterol metabolism were studied simultaneously by the use of appropriately labeled acetate and cholesterol. These techniques were also applied to an examination of the behavior of plasma cholesterol in four patients with hypercholesterolemia.

EFFECT OF HEPARIN ON PLASMA LIPID PARTITION IN MAN: STUDIES IN NORMAL PERSONS AND IN PATIENTS WITH CORONARY ATHEROSCLEROSIS, NEPHROSIS AND PRIMARY HYPERLIPEMIA

Excerpt This study is concerned with the effect of heparin on plasma lipid partition in man under normal and certain pathologic conditions. That heparin reduces the opacity of lipemic blood plasma ...

Tissue Permeability--a Factor in Atherogenesis: Studies with Cortisone and Hyaluronidase

Cortisone has a retarding effect on atherogenesis in cholesterol-fed rabbits, despite higher plasma cholesterol levels. This effect of cortisone is prevented by administration of hyaluronidase. The latter intensifies atherosclerosis and deposition of cholesterol in the liver.

Comparative studies of lipoproteins in various species by paper electrophoresis.

Summary 1. Paper electrophoresis provides a simple reproducible method for the study of serum (plasma) lipoproteins. Characteristic species lipoprotein patterns were demonstrated in normal man, monkey, dog and rabbit. 2. This method combined with chemical determinations of serum (plasma) lipids permits detailed investigations of normal and abnormal lipid metabolic states. 3. Elevation of serum (plasma) lipid fractions induced in these species by various experimental procedures were accompanied by a lowering of α lipoprotein and varying degrees of elevation of the β + O fraction.

Effect of Prolonged Use of Estrogens on Circulating Lipids in Patients with Idiopathic Hyperlipemia or Idiopathic Hypercholesteremia

The low incidence of atherosclerosis in premenopausal women and the effects of gonadal extracts on serum lipids indicate the desirability of further clinical and biochemical studies. Ethinyl estradiol was administered to 12 persons with idiopathic hyperlipemia or idiopathic hypercholesteremia. Medication was given for an average period of 16 months and was well tolerated, despite moderate gynecomastia, diminished libido, or uterine bleeding. The effects on the levels of circulating lipids and the clinical feasibility of this therapy are discussed.

Effect of Cortisone on Plasma Globulins in the Dog-Studies by Paper Electrophoresis.

Summary Cortisone administration to dogs is followed by a selective rise in plasma alpha-2 globulin and fall in beta globulin which is independent of any associated lipid changes; this shift in globulin distribution has not been observed in humans or rabbits receiving cortisone.

Experimental Atheromatosis: Acid Mucopolysaccharide Content of the Aorta

Histochemical and chemical studies of the acid mucopolysaccharide content of the aorta were made in rabbits fed cholesterol for up to seven months. Colloidal iron staining suggested an increase in acid mucopolysaccharide content of the aortas with mild atheromatous lesions but not when severe lesions were present. Chemical determination, however, revealed no increase in the concentration of acid mucopolysaccharide in early lesions, but did reveal a significant increase in the more severely atheromatous aortas of rabbits fed cholesterol for 6 months or more.

Lipoprotein Patterns by Starch Electrophoresis in Idiopathic Hyperlipemia and Hypercholesteremia

Starch electrophoresis was employed for the study of the lipoprotein patterns in inborn errors of lipid metabolism. Idiopathic hyperlipemia was characterized by marked increases of cholesterol and phospholipid in the alpha-2-lipoprotein fraction of the serum whereas idiopathic hypercholesteremia showed an increase of these lipids in the beta-lipoprotein fraction. The cholesterol and phospholipid contents in the alpha-1-lipoprotein fractions were diminished in both metabolic errors.