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Featured researches published by Chunjing Liu.


Zeitschrift für Naturforschung B | 2014

Synthesis of New TGX-221 Analogs

Chunjing Liu; Benyi Li; Lester Mitscher

TGX-221 is a potent phosphoinositide 3-kinase (PI3K)β inhibitor that has great therapeutic potential to treat prostate cancer. Chemical modification of TGX-221 at positions 2 and 9 was made. Five new TGX-221 analogs with different heterocyclic substituents of morpholine, 1-methylpiperazine, aniline, and thiazole-2-amine at positions 2 and 9 were synthesized. Parallel synthetic methods were employed in SN2 replacement reactions at positions 2 and 9 of TGX-221. Graphical Abstract Synthesis of New TGX-221 Analogs


Journal of Medicinal Chemistry | 2016

DARC: Mapping Surface Topography by Ray-Casting for Effective Virtual Screening at Protein Interaction Sites

Ragul Gowthaman; Sven A. Miller; Steven A. Rogers; Jittasak Khowsathit; Lan Lan; Nan Bai; David K. Johnson; Chunjing Liu; Liang Xu; Asokan Anbanandam; Jeffrey Aubé; Anuradha Roy; John Karanicolas


Archive | 2013

Selective small molecule activator of the apoptotic arm of the UPR

Daniel P. Flaherty; Jennifer E. Golden; Chunjing Liu; Michael Hedrick; Palak Gosalia; Yujie Li; Monika Milewski; Eliot Sugarman; Eigo Suyama; Kevin Nguyen; Stefan Vasile; Sumeet Salaniwal; Derek Stonich; Ying Su; Arianna Mangravita-Novo; Michael Vicchiarelli; Layton H. Smith; Jena Diwan; Thomas Dy Chung; Anthony B. Pinkerton; Jeffrey Aubé; Justin R. Miller; Danielle M. Garshott; Michael U. Callaghan; Andrew M. Fribley; Randal J. Kaufman


Archive | 2013

N-(pyridin-4-yl)benzo[d]thiazole-6-carboxamide inhibits E. coli UT189 bacterial capsule biogenesis

James W. Noah; Subramaniam Ananthan; Carrie W. Evans; N. Miranda Nebane; Lynn Rasmussen; Melinda Sosa; Nichole A. Tower; E. Lucile White; Patrick Seed; Carlos Goller; Mehreen Arshad; Apurba Datta; Benjamin Neuenswander; Patrick Porubsky; Brooks E. Maki; Chunjing Liu; Steven A. Rogers; Frank Schoenen; Jeffrey Aubé


Archive | 2013

CEPHALOSPORIN DERIVATIVES AND METHODS OF USE

Jeffrey Aubé; Carl Nathan; Robert A. Smith; Ben S. Gold; Paul R. Hanson; Chunjing Liu; Lester A. Mitscher; Maneesh Pingle; Frank J. Schoenen


Archive | 2013

Figure A6E, LCMS purity data at 214 nm for ML291 2nd batch –submitted to the MLSMR (SID 134228465, CID 52940465); LCMS retention time: 3.125 min; purity at 214 nm = 97.5%

Daniel P. Flaherty; Jennifer E. Golden; Chunjing Liu; Michael Hedrick; Palak Gosalia; Yujie Li; Monika Milewski; Eliot Sugarman; Eigo Suyama; Kevin Nguyen; Stefan Vasile; Sumeet Salaniwal; Derek Stonich; Ying Su; Arianna Mangravita-Novo; Michael Vicchiarelli; Layton H. Smith; Jena Diwan; Thomas Dy Chung; Anthony B. Pinkerton; Jeffrey Aubé; Justin R. Miller; Danielle M. Garshott; Michael U. Callaghan; Andrew M. Fribley; Randal J. Kaufman


Archive | 2013

Figure 4, Synthetic route for probe and analogue generation

James W. Noah; Subramaniam Ananthan; Carrie W. Evans; N. Miranda Nebane; Lynn Rasmussen; Melinda Sosa; Nichole A. Tower; E. Lucile White; Patrick Seed; Carlos Goller; Mehreen Arshad; Apurba Datta; Benjamin Neuenswander; Patrick Porubsky; Brooks E. Maki; Chunjing Liu; Steven A. Rogers; Frank Schoenen; Jeffrey Aubé


Archive | 2013

Table 1, Five probe analogues submitted to the NIH MLSMR, and their associated screening data

James W. Noah; Subramaniam Ananthan; Carrie W. Evans; N. Miranda Nebane; Lynn Rasmussen; Melinda Sosa; Nichole A. Tower; E. Lucile White; Patrick Seed; Carlos Goller; Mehreen Arshad; Apurba Datta; Benjamin Neuenswander; Patrick Porubsky; Brooks E. Maki; Chunjing Liu; Steven A. Rogers; Frank Schoenen; Jeffrey Aubé


Archive | 2013

Table 2, HTS data for compounds in the benzothiazole chemotype

James W. Noah; Subramaniam Ananthan; Carrie W. Evans; N. Miranda Nebane; Lynn Rasmussen; Melinda Sosa; Nichole A. Tower; E. Lucile White; Patrick Seed; Carlos Goller; Mehreen Arshad; Apurba Datta; Benjamin Neuenswander; Patrick Porubsky; Brooks E. Maki; Chunjing Liu; Steven A. Rogers; Frank Schoenen; Jeffrey Aubé


Archive | 2013

Figure 3, Graph depicting stability of the probe to thiol

James W. Noah; Subramaniam Ananthan; Carrie W. Evans; N. Miranda Nebane; Lynn Rasmussen; Melinda Sosa; Nichole A. Tower; E. Lucile White; Patrick Seed; Carlos Goller; Mehreen Arshad; Apurba Datta; Benjamin Neuenswander; Patrick Porubsky; Brooks E. Maki; Chunjing Liu; Steven A. Rogers; Frank Schoenen; Jeffrey Aubé

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Carrie W. Evans

Southern Research Institute

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E. Lucile White

Southern Research Institute

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Frank Schoenen

University of South Carolina

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James W. Noah

Southern Research Institute

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Lynn Rasmussen

Southern Research Institute

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