Chunjun Yang

Condylomata gigantea in a male transsexual

Summary As the incidence of genital warts increases, warts arising in the mouth, throat and other sites can occasionally be seen. Condyloma gigantea in genital sites are often reported, but literature on genital warts in transsexuals is rare. We present a case of C. gigantea in a 23-year-old male-to-female transsexual, whose warts arose on the transplanted skin of a neovagina and in the perianal region. We conclude that although C. gigantea can occur in transsexuals, the best way to treat it is not clear.

Holmium laser treatment of genital warts: an observational study of 1500 cases.

The treatment and relapse rate of genital warts are significant problems. The aim of this observational study was to assess the efficacy of holmium laser treatment of genital warts. A total of 1500 outpatients with genital human papillomavirus-induced lesions presenting from August 2002 to June 2005 were treated with holmium laser. The effects and side-effects of treatment were observed and analysed. Of this large cohort, lesions were excised at the first visit in 1488 cases. Twelve cases were treated a second or third time in the event that the lesions were too large to be removed at the first visit. The incidence of side-effects and complications after treatment with holmium laser was found to be low. Almost all warts can be excised at first treatment by holmium laser therapy with little bleeding during the treatment.

The study of the participation of basement membrane zone antibodies in the formation of the lupus band in systemic lupus erythematosus

Background  The lupus band test (LBT) is an important auxiliary method in the diagnosis of systemic lupus erythematosus (SLE), but the mechanism of its formation is still unknown. There are many kinds of autoantibodies, such as basement membrane zone autoantibodies (BMZ‐Abs), in patients with SLE.

Clinical efficacy of the 595 nm pulsed dye laser in the treatment of childhood superficial hemangioma - analysis of 10-year application in Chinese patients.

Abstract Background: The 595 nm tunable pulsed dye laser has been used in China for more than 10 years. However, no studies about its effect and side-effect in treatment of superficial hemangioma have been documented. Objective: This study was designed to retrospectively summarize its usage in Chinese patients. Methods: Infant patients with superficial hemangioma, who had received 595 nm tunable pulsed dye laser treatment in our laser center in the last 10 years, were recruited. Detailed demographics, results of assessment about their degree of clearance and clinical examination for treatment complications were entered into SASS10.0 version database, and statistical analyses were conducted. Results: Six hundred and fifty-seven cases with superficial hemangioma were recruited. The overall effectiveness rate was 91.17%. Female patients respond better than male, the difference was statistically significant (p < 0.001). Lesions at different part of the body respond differently to the treatment with lesions on extremities show the best result. The response rate does not increase with time of treatments. The most common side-effects were pigment changes and skin atrophy, which usually resolve spontaneously and disappear completely in a few months. Conclusions: Our experience confirmed the satisfactory clinical efficacy and safety of the 595 nm tunable pulse dye laser in the treatment of childhood superficial hemangioma.

Long-pulsed 1,064-nm high-energy dye laser improves resistant port wine stains: 20 report cases

Port wine stain (PWS) is one of the vascular birthmarks, which is commonly seen in the clinic. It is present at birth of the patients and grows commensurately [1]. The pulsed dynamic laser (PDL), which is based on selective photothermolysis, is now regarded as the first-line treatment for PWS [2]. The concept of selective photothermolysis with the 585and 595-nm PDL revolutionized the treatment of PWS, and most of PWS can be significantly lightened with the 595-nm PDL [3–5]. However, few PWS obtained complete recovery and nearly 20 to 30 % of them hardly lighten at all with PDL treatment [6]. In our cosmetic dermatology center, 595-nm PDL-resistant PWSwere documented since the last 6 years. In order to improve the treatment efficacy of the resistant PWS, we employed a new promising modality, long-pulsed yttrium– aluminum–garnet (YAG) 1,064-nm PDL, for the treatment of 595-nm PDL-resistant PWS. The aim of this study was to assess the role of the long-pulsed, 1,064-nm high-energy PDL in the treatment of resistant PWS.

Treatment of facial recalcitrant verruca vulgaris with holmium: YAG laser: An update

Abstract Objectives: To evaluate the effect and safety of the holmium: YAG laser in the treatment of facial recalcitrant verruca vulgaris. Methods: 42 patients with recalcitrant facial verruca vulgaris (64 warts in all) were enrolled in the study. Warts were treated with holmium: YAG pulsed dye laser with a top energy of 1.2–1.5 J, pulse frequency 10–12 Hertz, average power 10 Watt. Adverse reaction, complication, recurrence and clinical assessment of the lesion were documented with follow-up 6 months. Results: Ages of patients ranged from 16 to 73 years. 62 warts in 42 patients were eliminated by only one treatment session. The average time for wound-healing is 10.3 days. No severe discomfort, bleeding, edema, ulceration and secondary infection developed. No obvious complications were found. Only 4 warts in 3 patients remained mild atrophy scar and 7 warts in 6 patients remained pigment change. These defects became slighter after 6-month follow-up and left no bad effect on aesthetic. Two of the patients encountered recurrence in the treated site follow-up 6 months. Conclusions: Holmium laser is an effective and safe therapy for recalcitrant verruca vulgaris. It is the choice of treatment for those lesions in cosmetically sensitive areas.

Topical application of 5-aminolevulinic acid followed by 595-nm pulsed dye laser irradiation for the treatment of recalcitrant port-wine stains: a primary study.

Abstract Objective: To evaluate the effectiveness and safety of topical application of 5-aminolevulinic acid (ALA) followed by pulsed dye laser (PDL) irradiation for the treatment of recalcitrant port-wine stain (PWS). Methods: Thirty-five patients (19 females and 16 males) with recalcitrant PWS were treated with topical application of 20% ALA and then irradiated with a 595-nm PDL (energy density of 6.5–9.0 J/cm2 and pulse duration of 6 or 10 ms) at 6–8 weeks intervals. Clinical improvement of lesions was evaluated by comparing photographs of lesions at baseline and 2 months after the last treatment. Results: Topical ALA spreading followed by irradiation with a 595-nm PDL improved PWS in 21 out of 35 patients who were previously recalcitrant to PDL treatment alone. Side effects were limited to transient erythema, vesicle formation, edema and mild purpura with no obvious subsequent scarring or undesirable pigment changes. Conclusion: The topical application of ALA followed by irradiation with a 595-nm PDL is an effective and safe treatment for PWS recalcitrant to PDL therapy alone.

Combination effect of super pulsed carbon dioxide laser and photodynamic therapy for recalcitrant facial flat warts: A preliminary study

Changbing Shen1, Jing Gao2, Randy Ko 3, Zhongying Wang1, Shengxiu Liu1, Yongjiang Li1, Mingjun Tang1, Weiwei Yin1, Chunjun Yang1* and Xuejun Zhang1,2* 1Institute and Department of Dermatology, the First Affiliated Hospital, Anhui Medical University, Hefei 230032, Anhui, China 2Department of Dermatology, the Second Affiliated Hospital, Anhui Medical University, Hefei 230601, Anhui, China 3Department of Biochemistry, University of New Mexico, Albuquerque, NM 87131, New Mexico, USA *Corresponding author: Dr. Chunjun Yang, Institute and Department of Dermatology, the First Affiliated Hospital, Anhui Medical University, Hefei 230032, China, Tel: +86-551-65138576; Fax: +86-551-65138576; E-mail: yangchunjun9@163.com

Curative effect study of pulsed dye laser in the treatment of 43 patients with hand infantile hemangioma.

ObjectivePulsed dye laser has been proved to be fairly effective in the treatment of infantile hemangioma. But the effect varies in different body sites. The objective of this study was to assess the long-term outcome and complications of 595 nm pulsed dye laser in the treatment of hand infantile hemangioma in our laser department, retrospectively.Patients and MethodsThe patients with hand infantile hemangioma who had received pulsed dye laser (595 nmV-beam, Candela Cop., Wayland, MA. Parameters: fluence 10∼13 J/cm2, pulse duration 20∼40 ms, spot diameter 7 mm, epidermal cooling 20/40 s) treatment in past 5 years were recruited for the study. Detailed demographics, results of questionnaires and clinical examination were entered into a database and statistical analyses were conducted where applicable.Results43 patients with hand infantile hemangioma were recruited, including 29 females and 14 males, with a mean age of 8.92 months at treatment time. 7 patients with 10 hemangioma lesions at other sites from the hand meanwhile received laser treatment. There was a significant difference in the subjective assessment of clearing between hand lesions and additional other site hemangioma (p < 0.001). The average Patient Satisfaction Score was 7.25 for hand hemangioma, the average Patient Satisfaction Score was 4.45 for other site hemangioma lesions, there was a significant difference between hand and non-hand lesions (p < 0.001).Conclusions595 nm pulsed dye laser provides a safe and effective modality with lower morbidity for hand hemangioma.

Buschke-Löwenstein tumor in an old woman: cryotherapy and holmium laser treatment

Buschke-Lowenstein tumor (BLT) is a type of condyloma that occurs very rarely in female population [1]. The ratio of males to females is approximately 2.3:1 [2]. BLT is a slow-growing, expansive, cauliflower-like, destructive lesion which mainly affects the anogenital region, but it can propagate in vulvar, vaginal, rectum and bladder region as well [3–5]. BLT is often considered as a variant of verrucous carcinoma, and an exophytic lesion with low malignant potential. It is often referred to as a borderline malignant tumor due to its malignant transformation potential (invasion and recurrence after treatment), but no metastatic potential [2]. The exact origin, etiology and the most appropriate treatment of BLT are not completely understood yet. Common opinion is that it is a viral infection associated mostly with the presence of human papillomavirus (HPV) types 6, 11 and very rarely with the presence of HPV 16, 18. Malignant transformation is usually believed to be associated with oncogenic HPV 16/18. [6] Possible factors involved in the development of BLT include numerous sexual partners, poor hygiene, depression of immune system [7], HIV [8], local anaerobic infections, etc. We present a case of BLT in vulva and vagina with propagation on anal and perianal region in a patient whose lesions were successfully treated by the combined use of holmium laser excision and liquid nitrogen cryotherapy and there was no recurrence during 2.5 years’ follow-up. Cases series