Cindy R. Friedman
Memorial Sloan Kettering Cancer Center
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Publication
Featured researches published by Cindy R. Friedman.
Clinical Infectious Diseases | 2004
John T. Brooks; David Bergmire-Sweat; Malinda Kennedy; Kate Hendricks; Marianne Garcia; Lisa Marengo; Joy G. Wells; Michelle Ying; William F. Bibb; Patricia M. Griffin; Robert M. Hoekstra; Cindy R. Friedman
Few US clinical laboratories screen stool specimens for Shiga toxin-producing Escherichia coli (STEC) other than E. coli O157. An outbreak of STEC O111:H8 infections indistinguishable from E. coli O157:H7 at a youth camp highlights the need to improve non-O157 STEC surveillance. Interviews of 521 (80%) of 650 attendees revealed 55 (11%) were ill; 2 developed hemolytic-uremic syndrome. Illness was associated with consuming salad during the camps first lunch meal (hazard ratio [HR], 4.68; P<.01), consuming ice provided in barrels on the camps final day (HR, 3.41; P<.01), eating cob corn (HR, 3.22; P<.01), and eating a dinner roll (HR, 2.82; P<.01). Cultures of 2 of 11 stools yielded E. coli O111:H8. Results of serologic testing and additional stool cultures demonstrated no evidence of infection with other bacterial pathogens, including E. coli O157, and supported infection with E. coli O111. Clinical laboratories should routinely screen suspect specimens for non-O157 STEC and should serotype and report Shiga-positive isolates.
Foodborne Pathogens and Disease | 2012
John T. Brooks; Bela T. Matyas; John Fontana; Mary Ann DeGroot; Larry R. Beuchat; Michael Hoekstra; Cindy R. Friedman
A 1998 investigation of an outbreak of Salmonella serotype Typhimurium infections among children tasting unpasteurized milk during tours of a dairy farm demonstrated a distribution of unusually long incubation periods (median, 8 days; interquartile range [IQR], 6-14 days). Bacterial isolates were highly acid tolerant and contained genes associated with protection against destructive phagocytic reactive oxygen intermediates. We hypothesize that exposure to low-dose oral inoculum of a pathogen with these properties could have contributed to cases of non-typhoidal salmonellosis with the longest incubation period reported to the Centers for Disease Control and Prevention (CDC).
Emerging Infectious Diseases | 2017
R. Reid Harvey; Cindy R. Friedman; Stacy M. Crim; Michael Judd; Kelly A. Barrett; Beth Tolar; Jason P. Folster; Patricia M. Griffin; Allison C. Brown
Infection incidence and antimicrobial drug resistance are increasing.
Microbial Drug Resistance | 2017
Jason P. Folster; Julian Grass; Amelia Bicknese; Julia Taylor; Cindy R. Friedman; Jean M. Whichard
Salmonella is an important cause of foodborne illness; however, quickly identifying the source of these infections can be difficult, and source identification is a crucial step in preventing additional illnesses. Although most infections are self-limited, invasive salmonellosis may require antimicrobial treatment. Ceftriaxone, an extended-spectrum cephalosporin, is commonly used for treatment of salmonellosis. Previous studies have identified a correlation between the food animal/retail meat source of ceftriaxone-resistant Salmonella and the type of resistance gene and plasmid it carries. In this study, we examined seven outbreaks of ceftriaxone-resistant Salmonella infections, caused by serotypes Typhimurium, Newport, Heidelberg, and Infantis. All isolates were positive for a plasmid-encoded blaCMY gene. Plasmid incompatibility typing identified five IncI1 and two IncA/C plasmids. Both outbreaks containing blaCMY-IncA/C plasmids were linked to consumption of cattle products. Three of five outbreaks with blaCMY-IncI1 (ST12) plasmids were linked to a poultry source. The remaining IncI1 outbreaks were associated with ground beef (ST20) and tomatoes (ST12). In addition, we examined isolates from five unsolved clusters of ceftriaxone-resistant Salmonella infections and used our plasmid-encoded gene findings to predict the source. Overall, we identified a likely association between the source of ceftriaxone-resistant Salmonella outbreaks and the type of resistance gene/plasmid it carries.
Journal of Clinical Microbiology | 1995
Cindy R. Friedman; Mark Y. Stoeckle; Warren D. Johnson; Lee W. Riley
American Journal of Respiratory and Critical Care Medicine | 1995
Cindy R. Friedman; Mark Y. Stoeckle; Barry N. Kreiswirth; Warren D. Johnson; Seth Manoach; Judith Berger; Kumar Sathianathan; Alice Hafner; Lee W. Riley
Clinical Infectious Diseases | 1995
Kent A. Sepkowitz; Cindy R. Friedman; Alice Hafner; David Kwok; Seth Manoach; Michelle Floris; Diana Martinez; Kumar Sathianathan; Esther Brown; Judith Berger; Sorana Segal-Maurer; Barry Kreiswirth; Lee W. Riley; Mark Y. Stoeckle
International Journal of Tuberculosis and Lung Disease | 1997
Mannheimer Sb; Kent A. Sepkowitz; Mark Y. Stoeckle; Cindy R. Friedman; Alice Hafner; Lee W. Riley
Clinical Infectious Diseases | 1995
John Raffalli; Cindy R. Friedman; Darlene Reid; Rosemary Soave; Barrett H Childs; Kent A. Sepkowitz; Donald Armstrong
Journal of Clinical Microbiology | 2018
Reina Yamaji; Julia Rubin; Erika Thys; Cindy R. Friedman; Lee W. Riley