Clara Bonura

Sensor-Augmented Pump Therapy in Very Young Children with Type 1 Diabetes: An Efficacy and Feasibility Observational Study

BACKGROUND Efficacy and feasibility of sensor-augmented pump (SAP) therapy were evaluated in very young children with type 1 diabetes (T1D). SUBJECTS AND METHODS SAP (Dexcom [San Diego, CA] Seven Plus™ usage combined with insulin pump) therapy was retrospectively evaluated in 28 children (15 boys) younger than 7 years (mean age, 5.8 ± 1.2 years; range, 3-7 years), with T1D. Glycosylated hemoglobin (HbA1c) was evaluated at baseline and at the end of the study, as were efficacy and feasibility of the system, using a rating scale (with 3 being the most positive). RESULTS SAP has been used for at least 6 months by 85% of patients, with an overall good satisfaction (92%). The greatest perceived benefit was the reduced fear of hypoglycemia (score of 3, 81%). HbA1c significantly improved only in patients with baseline HbA1c >7.5% (P = 0.026). CONCLUSIONS SAP therapy is effective and feasible in preschool children with T1D. In patients with high HbA1c at baseline it provide a 0.9% decrease, sustained for at least 6 months.

Necrobiosis Lipoidica Diabeticorum: A pediatric case report

Introduction: Necrobiosis lipoidica (NL) is a rare chronic granulomatous dermatitis that usually appears in the lower extremities. It affects about 0.3–1.2% of diabetic patients, the majority of whom have type 1 diabetes. The etiology and pathogenesis of this disorder are still unclear. NL is characterized by skin rash that usually affects the shins. The average onset is 30 years, with females being affected more commonly. There are very few reported cases of necrobiosis lipoidica in children. Case report: We report a case of a 16 year old girl affected by type 1 diabetes mellitus (15 years disease duration) who developed an erythematous nodular rash on the lower extremities and interscapular area. In the suspect of necrobiosis lipoidica, a skin biopsy was performed (lower extremities and interscapular area). The microscopic evaluation of the pretibial lesions was suggestive of necrobiosis lipoidica. The smaller lesions in the interscapular area showed signs of perivascular dermatitis which could be consistent with early stages of necrobiosis lipoidica. Local treatment with tacrolimus determined a progressive improvement of the lesions. Conclusion: In patients with T1DM, diagnosis of NL of the lower legs is usually unequivocal. However, diagnosis may be more challenging in the presence of lesions with recent onset and/or atypical clinical presentation and unusual site. In these cases, NL must always be taken in consideration in order to avoid misdiagnosis, wrong/late treatment decisions, and progression to ulceration.

Can HbA1c combined with fasting plasma glucose help to assess priority for GCK-MODY vs HNF1A-MODY genetic testing?

Maurizio Delvecchio1 · Giuseppina Salzano2 · Clara Bonura3 · Vittoria Cauvin4 · Valentino Cherubini5 · Giuseppe d’Annunzio6 · Adriana Franzese7 · Sabrina Giglio8 · Valeria Grasso9 · Vanna Graziani10 · Dario Iafusco11 · Lorenzo Iughetti12 · Riccardo Lera13 · Claudio Maffeis14 · Giulio Maltoni15 · Vilma Mantovani16 · Claudia Menzaghi17 · Patrizia I. Patera18 · Ivana Rabbone19 · Petra Reindstadler20 · Sabrina Scelfo21 · Nadia Tinto22 · Sonia Toni23 · Stefano Tumini24 · Fortunato Lombardo2 · Antonio Nicolucci25 · Fabrizio Barbetti9,26 · The Diabetes Study Group of the Italian Society of Pediatric Endocrinology and Diabetes (ISPED)

Advanced Pump Functions: Bolus Calculator, Bolus Types, and Temporary Basal Rates

Over the past decade, technology has considerably changed insulin therapy in children and adolescents. A major improvement in insulin delivery has been achieved with the introduction of insulin pumps (CSII) and continuous glucose monitoring systems (CGM). The possibility to use advanced functions within these technological tools (different bolus types, bolus calculator, temporary basal rates) allows the patient to potentially achieve improved glucose control as well as lifestyle flexibility and quality of life.