Clare L. Clarke

Quantifying the cadence of free-living walking using event-based analysis

PURPOSE Free-living walking occurs over a wide range of durations and intensities (cadence). Therefore, its characterisation requires a full description of the distribution of duration and cadence of these walking events. The aim was to use event-based analysis to characterise this in a population with intermittent claudication (IC) and a healthy matched control group. METHODS Seven-day walking activity was recorded using the activPAL activity monitor in a group of people with IC (n=30) and an age-matched control group (n=30). The cadence, number of steps and duration of individual walking events were calculated and outcomes were derived, and compared (p<0.05), based on thresholds applied. RESULTS Both groups had similar number of walking events per day (392±117 vs 415±160). The control group accumulated a greater proportion of their walking at higher cadences and 32% of their steps were taken at a cadence above 100 steps/min, for the IC group this was 20%. Longer walking events had higher cadences and the IC group had fewer of these. As walking events became longer the cadence increased but the inter-event cadence variability decreased. More purposeful walking might occur at a higher cadence, and be performed at a preferred cadence. Individuals with IC had a smaller volume of walking, but these differences occurred almost entirely above a cadence of 90 steps/min. CONCLUSIONS This is the first study which has quantified the cadence of continuous periods of free-living walking. The characteristics (duration, number of steps and cadence) of all the individual walking events were used to derive novel outcomes, providing new insights into free-living walking behaviour.

Effect of two different participant information sheets on recruitment to a falls trial: An embedded randomised recruitment trial:

Background/Aims Recruitment to trials of intervention for older people who fall is challenging. Evidence suggests that the word falls has negative connotations for older people, and this may present a barrier to engaging with trials in this area. We therefore tested whether a participant information sheet that minimised reference to falls could improve recruitment rates. Methods We conducted a study within a trial, embedded within a randomised controlled trial of vitamin K versus placebo to improve postural sway in patients aged 65 and over with a history of falls. Potential participants were identified from primary care lists in 14 practices and were randomised to receive either a standard participant information sheet or an information sheet minimising use of the word falls, instead focussing on maintenance of health, fitness and balance. The primary outcome for this embedded trial was the proportion of responses expressing interest in participating received in each arm. Secondary outcomes were the proportion of those contacted attending a screening visit, consenting at screening, and the proportion contacted who were randomised into the main trial. Results In all, 4145 invitations were sent, with an overall response rate of 444 (10.7%). In all, 2148 individuals received the new information sheet (minimising reference to falls); 1997 received the standard information sheet. There was no statistically significant difference in response rate between those individuals sent the new information sheet and those sent the standard information sheet (10.1% vs 11.4%; difference 1.3% (95% confidence interval −0.6% to 3.2%); p = 0.19). Similarly, we found no statistically significant difference between the percentage of those who attended and consented at screening in the two groups (2.1% vs 2.7%; difference 0.6% (95% confidence interval: –0.4% to 1.6%); p = 0.20), and no statistically significant difference between the percentage randomised in the two groups (2.0% vs 2.6%; difference 0.6% (95% confidence interval −0.4% to 1.6%); p = 0.20) Conclusions Use of a participant information sheet minimising reference to falls did not lead to a greater response rate in this trial targeting older people with a history of falls.

The Effects of Medication on Activity and Rehabilitation of Older People – Opportunities and Risks:

Multiple medication use, or polypharmacy, is common in people undergoing rehabilitation. Polypharmacy is also common in older people, where it has the potential to impact on habitual physical activity. Despite this, the interactions between medication, disease, activity, and rehabilitation outcomes are insufficiently researched. In this review, we consider common classes of medications that can affect physical activity levels and outcomes of rehabilitation. We consider medications that improve disease processes and improve limiting symptoms (eg, breathlessness in heart failure and lung disease, pain in arthritis), unwanted side effects of medications (eg, central slowing caused by opioids and hypnotics), and also medication classes that might have the ability to improve activity and rehabilitation outcomes via beneficial effects on neuromuscular function (eg, angiotensin-converting enzyme inhibitors). We conclude by giving practical advice on how to review and optimise medication use to support habitual physical activity and ensure the best results from rehabilitation.