Claude Couture

Probing the binding site of the penicillin side-chain based on the tipper-strominger hypothesis

Abstract A series of 6-aminoacyl penams were prepared in order to simulate the D-ala-D-ala-OH portion of the donor muramyl peptide involved in the transpeptidation reaction during the formation of the bacterial cell wall. (R)-, and (S)-4-Aminoacyl-α-butyl α-benzyl penicillins were prepared as models, and their binding to PBPs was studied.