Claudia Araya

ApoER2 expression increases Aβ production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of γ-secretase activity

BackgroundThe generation of the amyloid-β peptide (Aβ) through the proteolytic processing of the amyloid precursor protein (APP) is a central event in the pathogenesis of Alzheimers disease (AD). Recent studies highlight APP endocytosis and localization to lipid rafts as important events favoring amyloidogenic processing. However, the precise mechanisms underlying these events are poorly understood. ApoER2 is a member of the low density lipoprotein receptor (LDL-R) family exhibiting slow endocytosis rate and a significant association with lipid rafts. Despite the important neurophysiological roles described for ApoER2, little is known regarding how ApoER2 regulates APP trafficking and processing.ResultsHere, we demonstrate that ApoER2 physically interacts and co-localizes with APP. Remarkably, we found that ApoER2 increases cell surface APP levels and APP association with lipid rafts. The increase of cell surface APP requires the presence of ApoER2 cytoplasmic domain and is a result of decreased APP internalization rate. Unexpectedly, ApoER2 expression correlated with a significant increase in Aβ production and reduced levels of APP-CTFs. The increased Aβ production was dependent on the integrity of the NPxY endocytosis motif of ApoER2. We also found that expression of ApoER2 increased APP association with lipid rafts and increased γ-secretase activity, both of which might contribute to increased Aβ production.ConclusionThese findings show that ApoER2 negatively affects APP internalization. However, ApoER2 expression stimulates Aβ production by shifting the proportion of APP from the non-rafts to the raft membrane domains, thereby promoting β-secretase and γ-secretase mediated amyloidogenic processing and also by incrementing the activity of γ-secretase.

Pex3p-dependent peroxisomal biogenesis initiates in the endoplasmic reticulum of human fibroblasts.

The mechanisms of peroxisomal biogenesis remain incompletely understood, specially regarding the role of the endoplasmic reticulum (ER) in human cells, where genetic disorders of peroxisome biogenesis lead to Zellweger syndrome (ZS). The Pex3p peroxisomal membrane protein (PMP) required for early steps of peroxisome biogenesis has been detected in the ER in yeast but not in mammalian cells. Here, we show that Pex3p‐GFP expressed in a new ZS cell line (MR), which lacks peroxisomes due to a mutation in the PEX3 gene, localizes first in the ER and subsequently in newly formed peroxisomes. Pex3p bearing an artificial N‐glycosylation site shows an electrophoretic shift indicative of ER targeting while en route to preformed peroxisomes in normal fibroblast. A signal peptide that forces its entry into the ER does not eliminate its capability to drive peroxisome biogenesis in ZS cells. Thus, Pex3p is able to drive peroxisome biogenesis from the ER and its ER pathway is not privative of ZS cells. Cross‐expression experiments of Pex3p in GM623 cells lacking Pex16p or Pex16p in MR cells lacking Pex3p, showed evidence that Pex3p requires Pex16p for ER location but is dispensable for the ER location of Pex16p. These results indicate that Pex3p follows the ER‐to‐peroxisomal route in mammalian cells and provides new clues to understand its function. J. Cell. Biochem. 107: 1083–1096, 2009.

Effect of Dimboa, a Hydroxamic Acid from Cereals, on Peroxisomal and Mitochondrial Enzymes from Aphids: Evidence for the Presence of Peroxisomes in Aphids

Abstract2,4-Dihydroxy-7-methoxy-1,4-benzoxazin-3-one (DIMBOA), a hydroxamic acid involved in the resistance of cereals to aphids, was administered to adult individuals of the aphid Sitobion avenae in artificial diets. Effects on the cellular metabolism were inferred from the evaluation of several organelle marker enzymes. Catalase from peroxisomes and cytochrome c oxidase from mitochondria increased their activities about twofold when aphids were fed with 2 mM DIMBOA. The role of these enzymes in the metabolizing of xenobiotics by aphids is discussed. Biochemical and cytochemical evidences for the presence of peroxisomes in aphids are reported here for the first time.

Cytochemical and Biochemical Demonstration of an ATPase in Membranes of Human Peroxisomes

We demonstrated a neutral Mg-ATPase activity in human peroxisomal membranes. To establish the precise experimental conditions for detection of this ATPase, both cytochemical and biochemical characterizations were first carried out in liver peroxisomes from control and cipofibrate-treated rats. The results demonstrated an Mg-ATPase reaction in both normal and proliferated peroxisomes. The nucleotidase activity, with marked preference for ATP, was sensitive to the inhibitors N-ethylmaleimide and 7-chloro-4-nitrobenzo-2-oxadiazole (NBDCl). An ultrastructural cytochemical analysis was developed to evaluate the peroxisomal localization, which localized the reaction product to the peroxisomal membrane. These characteristics can help to differentiate the peroxisomal ATPase from the activity found in mitochondria and endoplasmic reticulum. The conditions established for detecting the rat peroxisomal ATPase were then applied to human peroxisomes isolated from liver and skin fibroblasts in culture. A similar Mg-ATPase activity was readily shown, both cytochemically and biochemically, in the membranes of human peroxisomes. These results, together with previous evidence, strongly support the presence of a specific ATPase in the human peroxisomal membrane. This ATPase may play a crucial role in peroxisome biogenesis.

Relatos de histórias de casais no Chile atual: a intimidade como um monólogo coletivo

Important changes in the realm of intimacy have been described in light of the processes of social individualization. In this context, this research enquires the meanings and subjective experience regarding couple relationships, focusing in the psychological dimension of intimacy. Life histories from Chilean adult men and women who narrated their couple’s history were collected. The results call into question the assumption that this relationship is particularly representative of the domain of intimacy. When talking about couples the interviewees did not talk about intimacy. Instead, they conveyed a sense of fear or threaten, and the avoidance of the other in that realm. Their narratives show that the ideals regarding the couple are -paradoxicallyconstructed at an individual level, and this results in a way of being in a couple’s relationship that we have called “collective monologue”.

Relatos de historias de pareja en el Chile actual: la intimidad como un monólogo colectivo

Important changes in the realm of intimacy have been described in light of the processes of social individualization. In this context, this research enquires the meanings and subjective experience regarding couple relationships, focusing in the psychological dimension of intimacy. Life histories from Chilean adult men and women who narrated their couple’s history were collected. The results call into question the assumption that this relationship is particularly representative of the domain of intimacy. When talking about couples the interviewees did not talk about intimacy. Instead, they conveyed a sense of fear or threaten, and the avoidance of the other in that realm. Their narratives show that the ideals regarding the couple are -paradoxicallyconstructed at an individual level, and this results in a way of being in a couple’s relationship that we have called “collective monologue”.

Narratives of couple histories in Chile today: intimacy as a collective monologue

Important changes in the realm of intimacy have been described in light of the processes of social individualization. In this context, this research enquires the meanings and subjective experience regarding couple relationships, focusing in the psychological dimension of intimacy. Life histories from Chilean adult men and women who narrated their couple’s history were collected. The results call into question the assumption that this relationship is particularly representative of the domain of intimacy. When talking about couples the interviewees did not talk about intimacy. Instead, they conveyed a sense of fear or threaten, and the avoidance of the other in that realm. Their narratives show that the ideals regarding the couple are -paradoxicallyconstructed at an individual level, and this results in a way of being in a couple’s relationship that we have called “collective monologue”.

PPARβ/δ and PPARγ maintain undifferentiated phenotypes of mouse adult neural precursor cells from the subventricular zone” 2015 2015-03-18 Frontiers Media SA 36653316 9 78 78 60 3 3 Frontiers in Cellular Neuroscience 2016-06-24 2798921939 22747 Book archaeobotanical investigations of agriculture at late antique kom el nana tell el amarna Archaeobotanical Investigations of Agriculture at Late Antique Kom El-Nana (Tell El-Amarna) 2003 2003-01-01 0 8 8 2018-05-07 2772001607 24375 impacto economico de la reforma estructural ley 1819 del 2016 en las entidades sin animo de lucro del sector transportador en fusagasuga Impacto Económico de la Reforma Estructural (Ley 1819 del 2016) en las Entidades Sin Ánimo de Lucro del Sector Transportador en Fusagasugá 2017 2017-08-24 0 0 0 2017-12-22 2584119747 26261 flexural properties of equine long shaft bone Flexural properties of equine long shaft bone. 1980 1980-01-01 0 1 1 Flexural properties of equine long shaft bone. 2017-02-10 2051665361 25168 10.1203/00006450-197404000-00062 Journal risk factors in progeny of parents with premature myocardial infarction RISK FACTORS IN PROGENY OF PARENTS WITH PREMATURE MYOCARDIAL INFARCTION 1974 1974-04-01 Nature Publishing Group 167664057 8 4 350 350 0 1 1 Pediatric Research 2016-06-24 2798921946 36853 Book burma past and present Burma past and present 1878 1878-01-01 0 1 1 2018-05-07 2772001616 26991 contact de shunt automatique et methode de fabrication Contact de shunt automatique et methode de fabrication 1991 1991-09-20 0 0 0 2017-12-22 2584119748 21200 10.1016/B978-072160558-6.50031-9 chapter 28 tumors of the urinary system Chapter 28 – Tumors of the Urinary System 2007 2007-01-01 649 658 0 14 14 Withrow & MacEwen's Small Animal Clinical Oncology (Fourth Edition) 2017-02-10 2051665364 22067 10.1007/BF03183309 Journal manipulation and cutting of carbon nanotubes Manipulation and cutting of carbon nanotubes 2002 2002-10-01 Springer 86535114 47 20 1696 1700 10 4 4 Chinese Science Bulletin 2016-06-24 2798921952 24487 origin of mass and time Origin of Mass and Time 2016 2016-01-01 2 0 0 2018-05-07 2772001624 25102 on rust paint and preparation method thereof On rust paint and preparation method thereof 2010 2010-06-25 0 0 0 2017-12-22 2584119750 23614 разработка синхронного двигателя с постоянными магнитами на базе асинхронного двигателя с короткозамкнутым ротором Разработка синхронного двигателя с постоянными магнитами на базе асинхронного двигателя с короткозамкнутым ротором 2016 2016-01-01 Одесский национальный политехнический университет 0 0 0 2017-02-10 2051665367 24508 10.1051/sfmbcb/20125903011 prise en charge des mucites induites par bevacizumab et 5 fluoro uracile a propos d un cas Prise en charge des mucites induites par bévacizumab et 5-fluoro-uracile : à propos d’un cas 2012 2012-01-01 EDP Sciences 03011 0 0 0 59ème Congrès de la SFMBCB 2016-06-24 2798921957 24692 food and health policy in an age of austerity and globalization Food and Health Policy: In an Age of Austerity and Globalization 2014 2014-01-01 34 0 0 2018-05-07 2772001625 25081 method and apparatus for the measurement of connection properties of a material composite Method and apparatus for the measurement of connection properties of a material composite 2010 2010-05-03 0 0 0 2017-12-22 2584119755 25818 casualties of crime a literature review of assaults and accident and emergency departments Casualties of crime: a literature review of assaults and accident and emergency departments 2003 2003-01-01 0 0 0 2017-02-10 2051665370 22442 10.1111/bjir.12080 Journal working lives work in britain since 1945 by arthur mcivor palgrave basingstoke 2013 360 pp isbn 978 1 40 398766 2 60 00 hardback Working Lives: Work in Britain Since 1945, by Arthur McIvor. Palgrave, Basingstoke, 2013, 360 pp., ISBN: 978 1 40 398766 2, £60.00, hardback 2014 2014-09-01 London School of Economics 61595665 52 3 616 618 0 0 0 British Journal of Industrial Relations 2016-06-24 2798921962 22546 Book compared to what Compared to What 1991 1991-01-01 0 9 9 2018-05-07 2772001629 23917 10.3390/su9122215 Journal fostering nautical tourism in the balearic islands Fostering Nautical Tourism in the Balearic Islands 2017 2017-11-30 Multidisciplinary Digital Publishing Institute 10134376 9 12 2215 29 0 0 Sustainability 2017-12-22 2584119767 24249 여과분리형 생물반응조의 고액분리 특성 여과분리형 생물반응조의 고액분리 특성 2014 2014-08-01 한국습지학회 16 3 347 353 0 0 0 한국습지학회지 2017-02-10 2051665374 24243 10.1104/pp.49.4.467 Journal photoreduction and oxidation of cytochrome f in bundle sheath cells of maize Photoreduction and Oxidation of Cytochrome f in Bundle Sheath Cells of Maize 1972 1972-04-01 American Society of Plant Biologists 42294715 49 4 467 470 10 15 15 Plant Physiology 2016-06-24 2798921963 21097 Book disasters and democracy Disasters and democracy 1999 1999-01-01 0 25 25 2018-05-07 2772001633 24692 pure water gravure magenta ink for tipping paper and preparation method of pure water gravure magenta ink Pure water gravure magenta ink for tipping paper and preparation method of pure water gravure magenta ink 2014 2014-10-13 0 0 0 2017-12-22 2584119772 25716 modellbasierter datenaustausch und geowebservices im internet ma nchner fortbildungsseminar geoinformationssysteme tagungsband 9 muinchner fortbildungsseminar geoinformationssysteme 10 12 mairz 2004 veranstaltungsort technische universitait muinchen ma nchner fortbildungsseminar geoinformationssysteme 9 2004 tagungsband Modellbasierter Datenaustausch und Geowebservices im Internet; Münchner Fortbildungsseminar Geoinformationssysteme; Tagungsband / 9. MuÌnchner Fortbildungsseminar Geoinformationssysteme : 10. - 12. MaÌrz 2004, Veranstaltungsort: Technische UniversitaÌt MuÌnchen; Münchner Fortbildungsseminar Geoinformationssysteme (9.) 2004: Tagungsband 2004 2004-01-01 Technische Universität München Geodätisches Inst. 0 0 0 Tagungsband / 9. Münchner Fortbildungsseminar Geoinformationssysteme : 10. - 12. März 2004, Veranstaltungsort: Technische Universität München 2017-02-10 2051665377 33184 10.1007/BF01970738 Journal hat der krieg die operabilitat des uteruskrebses verschlechtert Hat der Krieg die Operabilität des Uteruskrebses verschlechtert 1922 1922-12-01 568598 117 1 216 221 0 0 0 Archives of Gynecology and Obstetrics 2016-06-24 2798921970 24385 Book pleasure and pain Pleasure and Pain 2017 2017-11-28 0 0 0 2018-05-07 2772001640 24010 10.1097/rhu.0000000000000648 Journal safe use of rituximab in an elderly patient with rheumatoid arthritis and severe heart failure a case report Safe Use of Rituximab in an Elderly Patient With Rheumatoid Arthritis and Severe Heart Failure: A Case Report 2017 2017-12-01 Ovid Technologies (Wolters Kluwer Health) 129376536 1 0 1 1 Jcr-journal of Clinical Rheumatology 2017-12-22 2584119778 24590 imagens da imigracao europeia nas pinturas de pedro weingartner representacao do imigrante e do processo de colonizacao seculo xix e xx Imagens da imigração europeia nas pinturas de Pedro Weingärtner: representação do imigrante e do processo de colonização (século XIX e XX) 2015 2015-04-24 Universidade do Vale do Rio dos Sinos 0 0 0 2017-02-10 2051665382 18639 10.1021/ja048472r Journal a solvent free secn secn 3 based ionic liquid electrolyte for high efficiency dye sensitized nanocrystalline solar cells A Solvent-Free, SeCN-/(SeCN)3- Based Ionic Liquid Electrolyte for High-Efficiency Dye-Sensitized Nanocrystalline Solar Cells 2004 2004-06-01 American Chemical Society 111155417 126 23 7164 7165 0 267 401 Journal of the American Chemical Society 2016-06-24 2798921998 24897 Book more things in heaven and earth More Things In Heaven and Earth 2012 2012-12-06 0 0 0 2018-05-07 2772001643 19841 10.1093/aje/kww175 Journal correction of selection bias in survey data is the statistical cure worse than the bias Correction of Selection Bias in Survey Data: Is the Statistical Cure Worse Than the Bias? 2017 2017-03-08 Oxford University Press 170967050 185 6 409 411 5 3 3 American Journal of Epidemiology 2017-12-22 2584119799 22473 verifying the performance of multiple linear regression in predicting the indicator of mass accumulation of waste the case of lubelskie voivodship Verifying the Performance of Multiple Linear Regression in Predicting the Indicator of Mass Accumulation of Waste : the Case of Lubelskie Voivodship 2016 2016-01-01 Wyższa Szkoła Zarządzania i Administracji w Zamościu 14 151 158 1 0 0 Barometr Regionalny. Analizy i prognozy 2017-02-10 2051665383 20828 10.1049/iet-gtd.2010.0462 Journal new fault zone identification scheme for busbar using support vector machine New fault zone identification scheme for busbar using support vector machine 2011 2011-01-01 IET 71857517 5 10 1073 1079 17 13 13 Iet Generation Transmission & Distribution 2016-06-24 2798922000 25423 Book jews and french quebecers two hundred years of shared history Jews and French Quebecers: Two Hundred Years of Shared History 1991 1991-01-01 0 3 3 2018-05-07 2772001644 24692 biguanide derivative as dpp iv dipeptidyl peptidase 4 inhibitor Biguanide derivative as DPP-IV (dipeptidyl peptidase-4) inhibitor 2014 2014-12-26 0 0 0 2017-12-22 2584119805 28479 polarization coupling loss sea gain effects in the ionospheric propagation of medium frequencies Polarization Coupling Loss & Sea Gain Effects in the Ionospheric Propagation of Medium Frequencies 1977 1977-12-01 NISCAIR-CSIR, India 0 0 0 IJRSP Vol.06(4) [December 1977] 2017-02-10 2051665384 22499 10.1088/0963-0252/16/1/006 Journal surface acid chemistry associated with dielectric barrier discharge dbd treatment of polyethylene Surface acid chemistry associated with dielectric barrier discharge (DBD) treatment of polyethylene 2007 2007-02-01 IOP Publishing 57082650 16 1 42 49 21 2 2 Plasma Sources Science and Technology 2016-06-24 2798922028 19936 Book spectral theory of linear operators Spectral theory of linear operators 2003 2003-01-01 0 36 61 2018-05-07 2772001646 26292 Patent verfahren und anordnung zur uberwachung eines endlostriebes einer brennkraftmaschine VERFAHREN UND ANORDNUNG ZUR ÜBERWACHUNG EINES ENDLOSTRIEBES EINER BRENNKRAFTMASCHINE 1998 1998-02-10 0 0 0 2017-12-22 2584119812 24336 estrategia para la formacion de la competencia didactica en los estudiantes de licenciatura en ciencias de educacion en fisica en el instituto superior de ciencias de educacion de huila angola ESTRATEGIA PARA LA FORMACIÓN DE LA COMPETENCIA DIDÁCTICA EN LOS ESTUDIANTES DE LICENCIATURA EN CIENCIAS DE EDUCACIÓN EN FÍSICA EN EL INSTITUTO SUPERIOR DE CIENCIAS DE EDUCACIÓN DE HUILA, ANGOLA 2017 2017-01-02 4 3 77 94 0 0 0 REFCalE: Revista Electrónica Formación y Calidad Educativa. ISSN 1390-9010 2017-02-10 2051665387 21776 10.1158/1535-7163.TARG-13-B226 Journal abstract b226 mir 148a dependent apoptosis of bladder cancer cells is mediated by the epigenetic modifier dnmt1 Abstract B226: MiR-148a dependent apoptosis of bladder cancer cells is mediated by the epigenetic modifier DNMT1. 2013 2013-11-01 American Association for Cancer Research 48437117 12 0 0 0 Molecular Cancer Therapeutics 2016-06-24 2798922034 19340 10.3847/1538-4357/aacd0e Journal a deeper look at the new milky way satellites sagittarius ii reticulum ii phoenix ii and tucana iii A Deeper Look at the New Milky Way Satellites: Sagittarius II, Reticulum II, Phoenix II, and Tucana III* 2018 2018-08-07 IOP Publishing 1980519 863 1 25 11 5 5 The Astrophysical Journal 2018-05-07 2772001648 25613 authentification de serveur Authentification de serveur 2005 2005-08-19 4 0 0 2017-12-22 2584119823 24760 10.7218/nenpouseijigaku.64.2_208 Journal the possibility of institutionalizing transnational deliberative democracy the lessons from eu s mini publics europolis 欧州における討論型世論調査の試みを一例として The Possibility of Institutionalizing Transnational Deliberative: Democracy: The Lessons from EU's Mini-publics (Europolis)@@@―欧州における討論型世論調査の試みを一例として― 2013 2013-01-01 2764764838 64 2 16 0 0 The annuals of Japanese Political Science Association 2017-02-10 2051665399 25732 10.1097/00006534-197910000-00080 Journal the care of the patient with minimal breast cancer The care of the patient with minimal breast cancer 1979 1979-10-01 100736837 64 4 578 0 0 0 Plastic and Reconstructive Surgery 2016-06-24 2798922039 26110 Book my mother and me My Mother and Me 2000 2000-01-15 0 0 0 2018-05-07 2772001651 24998 수치심과 죄책감에 대한 성경적 이해와 치유를 위한 기독교상담적 접근 수치심과 죄책감에 대한 성경적 이해와 치유를 위한 기독교상담적 접근 2011 2011-01-01 한국복음주의상담학회 16 225 249 0 0 0 복음과 상담 2017-12-22 2584119825 24692 problems of using digital cryptocurrency bitcoin Problems of Using Digital Cryptocurrency Bitcoin 2014 2014-01-01 Видавництво НГУ 0 0 0 2017-02-10 2051665404 21634 10.1097/COC.0b013e318297f333 Journal clinical significance of abcg2 haplotype tagging single nucleotide polymorphisms in patients with unresectable non small cell lung cancer treated with first line platinum based chemotherapy Clinical Significance of ABCG2 Haplotype-tagging Single Nucleotide Polymorphisms in Patients With Unresectable Non-Small Cell Lung Cancer Treated With First-line Platinum-based Chemotherapy. 2015 2015-06-01 Lippincott Williams and Wilkins 130927242 38 3 294 299 29 3 3 American Journal of Clinical Oncology 2016-06-24 2798922064 23580 10.3150/17-BEJ952 Journal simultaneous nonparametric regression analysis of sparse longitudinal data Simultaneous nonparametric regression analysis of sparse longitudinal data 2018 2018-11-01 Bernoulli Society for Mathematical Statistics and Probability 172538041 24 3013 3038 23 0 0 Bernoulli 2018-05-07 2772001652 25775 Patent vorrichtung zum einstellen des arbeitsspaltes zwischen den spitzen von deckelgarnituren und den spitzen der trommelgarnitur einer karde device for adjusting the working gap between the tips of flat tops and the tips of the cylinder clothing of a card Vorrichtung zum Einstellen des Arbeitsspaltes zwischen den Spitzen von Deckelgarnituren und den Spitzen der Trommelgarnitur einer Karde Device for adjusting the working gap between the tips of flat tops and the tips of the cylinder clothing of a card 2000 2000-08-02 0 0 0 2017-12-22 2584119828 25511 a new trial and the inspection of child care support in the information intensive society through mothers communication on the bbs for the period of their child care A new trial and the Inspection of child care support in the information-intensive society: through mothers' communication on the BBS for the period of their child care 2006 2006-03-01 香川大学生涯学習教育研究センタ- 11 15 34 0 0 0 Research review of Education and Research Center for Lifelong Learning,Kagawa University 2017-02-10 2051665407 27744 10.1139/v65-362 Journal concerning the preparation of p allylphenol from safrole by sodium liquid ammonia reduction CONCERNING THE PREPARATION OF p-ALLYLPHENOL FROM SAFROLE BY SODIUM – LIQUID AMMONIA REDUCTION 1965 1965-09-01 NRC Research Press Ottawa, Canada 9189650 43 9 2621 2624 0 1 1 Canadian Journal of Chemistry 2016-06-24 2798922067 23812 Book the finishing school The Finishing School 2004 2004-03-09 0 1 1 2018-05-07 2772001655 25409 macro diversity method system and device using multi community associated detection method Macro diversity method, system and device using multi-community associated detection method 2007 2007-04-23 0 0 0 2017-12-22 2584119830 23835 ecologia y comportamiento de las ranas venenosas del genero oophaga en costa rica y panama Ecología y comportamiento de las ranas venenosas del género oophaga en Costa Rica y Panamá 2015 2015-01-01 ISSCA 32 32 31 45 0 0 0 Alytes; 32(32), pp 31-45 (2015) 2017-02-10 2051665411 21695 10.1080/10407780701364122 Journal upward heat flux through the horizontal fluid layer of water with sinusoidal wall temperature at the top or bottom boundary Upward Heat Flux Through the Horizontal Fluid Layer of Water with Sinusoidal Wall Temperature at the Top or Bottom Boundary 2007 2007-09-13 Taylor & Francis Group 84964104 52 9 817 829 23 7 7 Numerical Heat Transfer Part A-applications 2016-06-24 2798922079 25516 Book salmon p chase Salmon P. Chase 1980 1980-01-01 0 4 4 2018-05-07 2772001659 24358 10.17073/0368-0797-2017-8-670-678 Journal development and implementation of automated heating system for holding furnaces in non ferrous metallurgy DEVELOPMENT AND IMPLEMENTATION OF AUTOMATED HEATING SYSTEM FOR HOLDING FURNACES IN NON-FERROUS METALLURGY 2017 2017-01-01 2764965863 60 8 670 678 0 0 0 Izvestiya Visshikh Uchebnykh Zavedenii. Chernaya Metallurgiya 2017-12-22 2584119887 24385 10.6084/m9.figshare.4591621.v1 powerpoint slides for insights from screening a racially and ethnically diverse population for chronic kidney disease PowerPoint Slides for: Insights from Screening a Racially and Ethnically Diverse Population for Chronic Kidney Disease 2017 2017-01-27 0 0 0 2017-02-10 2051665413 21047 10.1016/j.prevetmed.2012.11.020 Journal major causes of organs and carcass condemnation in small ruminants slaughtered at luna export abattoir oromia regional state ethiopia Major causes of organs and carcass condemnation in small ruminants slaughtered at Luna Export Abattoir, Oromia Regional State, Ethiopia. 2013 2013-06-01 Elsevier 178566096 110 2 139 148 10 14 14 Preventive Veterinary Medicine 2016-06-24 2798922091 24897 Book the game of cricket The Game Of Cricket 2012 2012-02-10 0 0 0 2018-05-07 2772001660 23233 Patent paint for forming infrared ray shielding film and infrared ray shielding material Paint for forming infrared ray shielding film and infrared ray shielding material 2008 2008-01-18 0 1 1 2017-12-22 2584119903 26185 Patent verfahren zur umwandlung von schweren roholen und destillationsruckstanden in destillate a process for the conversion of heavy crude oils and distillation residues in distillates Verfahren zur Umwandlung von schweren Rohölen und Destillationsrückständen in Destillate A process for the conversion of heavy crude oils and distillation residues in distillates 1996 1996-05-24 0 0 0 2017-02-10 2051665414 33486 10.1016/S0140-6736(00)33011-2 Journal case of remarkable risings and fallings of the bodily temperature with remarks CASE OF REMARKABLE RISINGS AND FALLINGS OF THE BODILY TEMPERATURE, WITH REMARKS. 1885 1885-07-01 Elsevier 49861241 126 3227 4 6 0 4 4 The Lancet 2016-06-24 2798922101 25807 statistical properties of laser sparkle patterns STATISTICAL PROPERTIES OF LASER SPARKLE PATTERNS 1963 1963-12-01 0 6 112 2018-05-07 2772001663 26429 easy disposal method of working solution based on w o type invert emulsion Easy disposal method of working solution based on w / o type invert emulsion 1997 1997-10-21 0 0 0 2017-12-22 2584119918 24277 il ruolo della conoscenza paesaggistica dell italia nel processo di costruzione della coscienza nazionale il caso de il bel paese di antonio stoppani Il ruolo della conoscenza paesaggistica dell’Italia nel processo di costruzione della coscienza nazionale. Il caso de Il Bel Paese di Antonio Stoppani 2016 2016-01-01 Eum edizioni università di Macerata 37 51 0 0 0 2017-02-10 2051665416 20855 10.3324/haematol.11503 Journal acquisition of loss of the wild type nras locus with aggressive disease progression in a patient with juvenile myelomonocytic leukemia and a heterozygous nras mutation Acquisition of loss of the wild-type NRAS locus with aggressive disease progression in a patient with juvenile myelomonocytic leukemia and a heterozygous NRAS mutation 2007 2007-11-01 FERRATA STORTI FOUNDATION 2752781272 92 11 1576 1578 9 15 15 Haematologica 2016-06-24 2798922125 24590 Book waves of passion Waves of Passion 2015 2015-04-01 0 0 0 2018-05-07 2772001664 21446 Patent image processing management device program and image processing management system Image processing management device, program and image processing management system 2009 2009-09-11 6 3 3 2017-12-22 2584119919 26417 10.1016/B978-0-444-42497-6.50008-4 chapter 4 gossans Chapter 4 – GOSSANS 1985 1985-01-01 261 390 82 1 1 Regional Studies and Specific Deposits, Volume 13 2017-02-10 2051665420 22816 10.4028/www.scientific.net/AMM.556-562.5614 Journal the mode of self learning information The Mode of Self-Learning Information 2014 2014-05-01 Trans Tech Publications 128754310 5614 5617 0 0 0 Applied Mechanics and Materials 2016-06-24 2798922154 26432 Book no liberty for license the forgotten logic of the first amendment No Liberty for License: The Forgotten Logic of the First Amendment 1997 1997-10-15 0 0 0 2018-05-07 2772001665 25322 production of micro and nano porous mass arrangements by self assembly of nanoparticles and sublimation Production of micro- and nano-porous mass arrangements by self-assembly of nanoparticles and sublimation 2007 2007-05-29 0 0 0 2017-12-22 2584119923 24610 10.1016/B978-0-08-026250-5.50037-X c3 absorption of carbonyl sulphide in amines and alkalis C3 – Absorption of carbonyl sulphide in amines and alkalis 1981 1981-01-01 199 201 3 0 0 Insights Into Chemical Engineering#R##N#Selected Papers of P.V. Danckwerts 2017-02-10 2051665422 20915 10.1167/iovs.08-2432 Journal nonessential role of β3 and β5 integrin subunits for efficient clearance of cellular debris after light induced photoreceptor degeneration Nonessential Role of β3 and β5 Integrin Subunits for Efficient Clearance of Cellular Debris after Light-Induced Photoreceptor Degeneration 2009 2009-03-01 The Association for Research in Vision and Ophthalmology 76304953 50 3 1423 1432 48 14 14 Investigative Ophthalmology & Visual Science 2016-06-24 2798922157 22831 Journal reading minds a study of deictic shifts in translated written interaction between mental health professionals and their readers Reading minds: A study of deictic shifts in translated written interaction between mental-health professionals and their readers 2012 2012-01-01 Artesis Hogeschool Antwerpen - Hoger Instituut voor Vertalers en Tolken 2764898092 11 51 73 18 1 1 Linguistica Antverpiensia, New Series – Themes in Translation Studies 2018-05-07 2772001668 24385 un monde robotise Un monde robotisé 2017 2017-11-29 0 0 0 2017-12-22 2584119932 19930 10.1021/acs.chemrev.6b00210 Journal recent advances in the chemistry of pentafulvenes Recent Advances in the Chemistry of Pentafulvenes 2017 2017-03-08 American Chemical Society 41143188 117 5 3930 3989 420 18 18 Chemical Reviews 2017-02-10 2051665424 21420 10.1007/s10722-011-9659-8 Journal spatial patterns of adenylate kinase catalase endopeptidase and fructose 1 6 diphosphatase encoding genes allelic variation in aegilops tauschii coss Spatial patterns of adenylate kinase, catalase, endopeptidase and fructose-1,6-diphosphatase encoding genes allelic variation in Aegilops tauschii Coss. 2012 2012-01-01 Springer Netherlands 96567077 59 1 1 8 15 10 10 Genetic Resources and Crop Evolution 2016-06-24 2798922159 22305 Book the end of japan inc The end of Japan Inc. 1994 1994-01-01 0 9 9 2018-05-07 2772001669 26311 procede et dispositif de production de vapeur a l aide de l energie solaire Procede et dispositif de production de vapeur a l'aide de l'energie solaire 1995 1995-03-03 0 0 0 2017-12-22 2584119936 24794 library archives page 26 of 69 oii australia intersex australia Library Archives - Page 26 of 69 - OII Australia - Intersex Australia 2013 2013-03-22 0 0 0 2017-02-10 2051665425 22214 10.1136/bmj.316.7130.560a Journal around every tumour there s a person Around every tumour there's a person 1998 1998-02-14 British Medical Journal Publishing Group 192814187 316 7130 560 561 0 2 2 BMJ 2016-06-24 2798922161 25409 Book the good thief The Good Thief 2007 2007-09-01 0 0 0 2018-05-07 2772001671 25755 stent a greffer autoexpansible Stent à greffer autoexpansible 2001 2001-01-31 0 0 0 2017-12-22 2584119938 23848 game usability in north american video game industry Game usability in North American video game industry 2016 2016-01-01 0 1 1 2017-02-10 2051665426 22232 10.1097/00128360-200401000-00002 Journal the international federation for cervical pathology and colposcopy ifcpc The International Federation for Cervical Pathology and Colposcopy (IFCPC). 2004 2004-01-01 J Low Genit Tract Dis 6499114 8 1 3 5 3 3 3 Journal of Lower Genital Tract Disease 2016-06-24 2798922162 26432 Book the great adventure The great adventure 1997 1997-01-01 0 0 0 2018-05-07 2772001672 25920 de markt en de ondergang van de beschaving in jaarboek kvs 2001 2002 De markt en de ondergang van de beschaving, in Jaarboek KVS 2001/2002 2002 2002-01-01 144 146 0 0 0 Economisch Statistische Berichten 2017-12-22 2584119939 24692 10.1016/B978-1-895198-65-2.50011-9 21 solvent recycling removal and degradation 21 – SOLVENT RECYCLING, REMOVAL, AND DEGRADATION 2014 2014-01-01 787 825 42 0 0 Handbook of Solvents (Second Edition)#R##N#Volume 2: Use, Health, and Environment 2017-02-10 2051665428 21827 10.1016/j.neures.2006.01.003 Journal stimulated single fiber electromyography monitoring of anti sense induced changes in experimental autoimmune myasthenia gravis Stimulated-single fiber electromyography monitoring of anti-sense induced changes in experimental autoimmune myasthenia gravis 2006 2006-05-01 Elsevier 8734658 55 1 40 44 16 10 10 Neuroscience Research 2016-06-24 2798922180 21730 10.1109/apec.2018.8341571 Conference a series resonance based three port converter with unified autonomous control method in dc microgrids A series-resonance-based three-port converter with unified autonomous control method in DC microgrids 2018 2018-03-01 IEEE 2624557529 2626121507 0 0 0 applied power electronics conference 2018-05-07 2772001677 24165 10.1007/s12498-017-0518-1 Journal hiv en werkvermogen Hiv en werkvermogen 2017 2017-12-01 Bohn Stafleu van Loghum 37101086 25 10 488 488 1 0 0 Tijdschrift Voor Bedrijfs- En Verzekeringsgeneeskunde 2017-12-22 2584119941 25102 review of the book pater ignatius spencer passionist pionier van het oecumenisch gebed j van den bussche Review of the book Pater Ignatius Spencer, passionist. Pionier van het Oecumenisch Gebed, J. van den Bussche 2010 2010-01-01 40 1 113 114 0 0 0 Collationes: Vlaams Tijdschrift voor Theologie en Pastoraal 2017-02-10 2051665435 23475 10.1139/v80-433 Journal catalytic reduction of dimeric acetylated 2 deoxy 2 nitroso α d glycopyranosyl chlorides Catalytic reduction of dimeric acetylated 2-deoxy-2-nitroso-α-D-glycopyranosyl chlorides 1980 1980-12-01 NRC Research Press Ottawa, Canada 9189650 58 23 2720 2723 0 5 5 Canadian Journal of Chemistry 2016-06-24 2798922183 27046 Book take me to your liter Take Me to Your Liter 1991 1991-04-01 0 0 0 2018-05-07 2772001678 20649 10.1007/s11056-017-9623-3 Journal biodiversity field trials to inform reforestation and natural resource management strategies along the african great green wall in senegal Biodiversity field trials to inform reforestation and natural resource management strategies along the African Great Green Wall in Senegal 2018 2018-05-01 Springer Netherlands 199475400 49 3 341 362 23 0 0 New Forests 2017-12-22 2584119956 20841 cities fighting inequality Cities Fighting Inequality 2015 2015-11-14 Appam 0 0 0 2015 Fall Conference: The Golden Age of Evidence-Based Policy 2017-02-10 2051665437 24268 10.1007/BF02375530 Journal catalytic and electrocatalytic oxidation of ethylene on a perovskite electrode in a solid electrolyte cell Catalytic and electrocatalytic oxidation of ethylene on a perovskite electrode in a solid electrolyte cell 1997 1997-01-01 137979523 3 96 103 11 3 3 Ionics 2016-06-24 2798922192 30043 Book elements of biology Elements of biology 1950 1950-01-01 0 1 1 2018-05-07 2772001680 22040 Patent decorative cover substrate for touch panel and method for manufacturing the same Decorative cover substrate for touch panel and method for manufacturing the same 2013 2013-04-08 6 1 1 2017-12-22 2584119961 21154 10.1007/s00586-017-4947-4 Journal atypical presentation of a cervical synovial cyst Atypical presentation of a cervical synovial cyst 2017 2017-09-01 Springer Berlin Heidelberg 100227592 26 9 2267 2271 13 3 3 European Spine Journal 2017-02-10 2051665442 19585 10.1145/1276377.1276473 Conference the influence of shape on the perception of material reflectance The influence of shape on the perception of material reflectance 2007 2007-07-29 ACM 1164321581 2790646106 26 3 77 31 87 127 international conference on computer graphics and interactive techniques 2016-06-24 2798922195 23295 vaccine antigen databases Vaccine Antigen Databases 2013 2013-01-01 23 0 0 2018-05-07 2772001684 24924 Patent system zum schutz vor embolien und zur entfernung von embolischem material System zum Schutz vor Embolien und zur Entfernung von embolischem Material 2009 2009-09-15 0 0 0 2017-12-22 2584119965 21393 Journal pharmacokinetics and pharmacodynamics after subcutaneous dosing of the inkt cell depleting antibody nktt120 Pharmacokinetics and Pharmacodynamics after Subcutaneous Dosing of the iNKT Cell Depleting Antibody NKTT120 2015 2015-12-03 American Society of Hematology 200071133 126 23 4575 4575 0 0 0 Blood 2017-02-10 2051665443 21448 10.1126/science.7423209 Journal medial nucleus of the amygdala mediates chemosensory control of male hamster sexual behavior Medial nucleus of the amygdala mediates chemosensory control of male hamster sexual behavior 1980 1980-10-31 American Association for the Advancement of Science 3880285 210 4469 557 560 21 234 262 Science 2016-06-24 2798922197 23661 Journal transitive psl 2 11 invariant k arcs in pg 4 q Transitive PSL(2,11)-invariant k-arcs in PG(4,q) 2018 2018-04-25 2596562499 0 0 0 arXiv: Combinatorics 2018-05-07 2772001685 27489 driver to horn adaptor Driver to horn adaptor 1986 1986-06-13 0 0 0 2017-12-22 2584119971 24487 metodos de conservacao e manipulacao dos corpos do laboratorio de anatomia humana da unisc MÉTODOS DE CONSERVAÇÃO E MANIPULAÇÃO DOS CORPOS DO LABORATÓRIO DE ANATOMIA HUMANA DA UNISC. 2016 2016-10-25 60 0 0 0 Seminário de Iniciação Científica 2017-02-10 2051665447 21799 10.1109/EPE.2014.6839525 Conference experimental validation of solid oxide fuel cell s basic operational characteristic Experimental validation of solid oxide fuel cell's basic operational characteristic 2014 2014-05-01 IEEE 2753951326 315 319 21 1 1 international scientific conference on electric power engineering 2016-06-24 2798922212 25102 Book the miracle tree The Miracle Tree 2010 2010-05-31 0 0 0 2018-05-07 2772001686 24590 etude et realisation de maintenance en entreprise typologie de projet e62 sciences et techniques industrielles Étude et réalisation de maintenance en entreprise, typologie de projet (E62) - Sciences et techniques industrielles 2015 2015-04-10 Sciences et techniques industrielles 0 0 0 2017-12-22 2584119980 23715 perspektiver pa internationalt anerkendte musikterapiretninger en introduktion Perspektiver på internationalt anerkendte musikterapiretninger - en introduktion 2014 2014-10-07 Klim 177 179 0 0 0 2017-02-10 2051665451 20478 10.1016/S0378-1127(02)00437-1 Journal performance of 31 tree species and soil conditions in a plantation established with saline irrigation Performance of 31 tree species and soil conditions in a plantation established with saline irrigation 2003 2003-04-01 Elsevier 195255895 177 1 333 346 13 58 101 Forest Ecology and Management 2016-06-24 2798922218 21737 lessons from iavi 006 a phase i clinical trial to evaluate the safety and immunogenicity of the pthr hiva dna and mva hiva vaccines in a prime boost strategy to induce hiv 1 specific t cell responses in healthy volunteers vol 26 pg 6671 2008 Lessons from IAVI-006, a Phase I clinical trial to evaluate the safety and immunogenicity of the pTHr.HIVA DNA and MVA.HIVA vaccines in a prime-boost strategy to induce HIV-1 specific T-cell responses in healthy volunteers (vol 26, pg 6671, 2008) 2011 2011-04-18 ELSEVIER SCI LTD 0 0 0 VACCINE , 29 (18) p. 3511. (2011) 2018-05-07 2772001696 26432 trade liberalization and belizean agriculture implications Trade Liberalization and Belizean Agriculture: Implications 1997 1997-01-01 0 0 0 2017-12-22 2584119988 21060 10.1016/j.leukres.2017.01.032 Journal markers of iron deficiency in patients with polycythemia vera receiving ruxolitinib or best available therapy Markers of iron deficiency in patients with polycythemia vera receiving ruxolitinib or best available therapy 2017 2017-05-01 Elsevier Limited 136942575 56 52 59 39 3 3 Leukemia Research 2017-02-10 2051665456 25885 10.1001/jama.1947.02890030013004 Journal meningitis due to candida monilia albicans with recovery Meningitis due to Candida (Monilia) albicans with recovery. 1947 1947-09-20 American Medical Association 172573765 135 3 145 147 3 19 19 JAMA 2016-06-24 2798922224 27660 Book the water cycle The Water Cycle 1985 1985-01-01 0 0 0 2018-05-07 2772001700 24487 Patent laryngeal mask with multiple pipe cavities Laryngeal mask with multiple pipe cavities 2016 2016-10-19 7 0 0 2017-12-22 2584120011 24225 10.1007/978-1-137-54504-6_62 BookChapter civil procedure rules 1998 pd 54a judicial review Civil Procedure Rules 1998, PD 54A — Judicial Review Core Statutes on Public Law & Civil Liberties 2015 2015-01-01 Macmillan Education UK 350 353 0 0 0 2017-02-10 2051665461 22254 10.1007/s10826-013-9777-3 Journal risk trajectories of self destructiveness in adolescence family core influences Risk Trajectories of Self-Destructiveness in Adolescence: Family Core Influences 2014 2014-10-01 Springer US 87914957 23 7 1172 1181 38 3 3 Journal of Child and Family Studies 2016-06-24 2798922248 23053 Book it came from outer space It Came from Outer Space 2004 2004-01-01 0 1 1 2018-05-07 2772001701 24385 kekuatan komunikasi media lembaga penyiaran publik lokal lppl radio dalam pelestarian budaya dan kearifan lokal pada lembaga penyiaran publik lokal lppl radio mahardhika fm blitar KEKUATAN KOMUNIKASI MEDIA LEMBAGA PENYIARAN PUBLIK LOKAL (LPPL) RADIO DALAM PELESTARIAN BUDAYA DAN KEARIFAN LOKAL PADA LEMBAGA PENYIARAN PUBLIK LOKAL (LPPL) RADIO MAHARDHIKA FM BLITAR 2017 2017-04-04 1 1 0 0 0 Prosiding Strengthening Local Communities Facing The Global Era 2017-12-22 2584120018 25204 10.1016/B978-84-8086-374-2.50030-6 autor del capitulo 12 Autor del Capítulo 12 2009 2009-01-01 0 0 0 Cirugía del Estrabismo.Técnicas Quirúrgicas en Oftalmología 2017-02-10 2051665473 20872 10.1117/12.671625 Journal ape segment pattern recognition in new phasing techniques APE segment pattern recognition in new phasing techniques 2006 2006-06-14 International Society for Optics and Photonics 183492911 6267 626738 5 5 5 Proceedings of SPIE 2016-06-24 2798922252 24019 10.1109/ieses.2018.8349860 interleaved high step up dc dc converter with three winding coupled inductors for renewable energy system Interleaved high step-up DC-DC converter with three-winding coupled inductors for renewable energy system 2018 2018-01-01 IEEE 0 0 0 2018 IEEE International Conference on Industrial Electronics for Sustainable Energy Systems (IESES) 2018-05-07 2772001708 24590 Patent packet transmission method apparatus and system Packet transmission method, apparatus and system 2015 2015-07-17 0 0 0 2017-12-22 2584120031 24111 Patent 염산 및 폴리머를 이용하여 개질된 레드 머드를 제조하는 방법 염산 및 폴리머를 이용하여 개질된 레드 머드를 제조하는 방법 2013 2013-02-19 2 0 0 2017-02-10 2051665480 33392 10.1080/19447012908666037 rational development in the organisation of the cotton industry RATIONAL DEVELOPMENT IN THE ORGANISATION OF THE COTTON INDUSTRY 1929 1929-02-01 Taylor & Francis Group 20 2 0 0 0 Journal of the Textile Institute Proceedings 2016-06-24 2798922262 24627 Journal el imaginario teotihuacano el espacio urbano como espacio simbolico EL IMAGINARIO TEOTIHUACANO: EL ESPACIO URBANO COMO ESPACIO SIMBÓLICO 2012 2012-06-19 135297974 58 135 156 0 0 0 Acta Sociologica 2018-05-07 2772001711 26023 小児の症候群 胎児ヒダントイン症候群 fetal hydantoin syndrome 小児の症候群 胎児ヒダントイン症候群(fetal hydantoin syndrome) 2001 2001-01-01 64 73 0 0 0 小児科診療 2017-12-22 2584120034 24283 10.22108/amf.2017.21193 عوامل مؤثر در بازده سهام شرکتهای پذیرفتهشده در بورس اوراق بهادار تهران رویکرد فراتحلیل عوامل مؤثر در بازده سهام شرکتهای پذیرفتهشده در بورس اوراق بهادار تهران: رویکرد فراتحلیل 2018 2018-04-21 دانشگاه اصفهان 6 1 29 50 0 0 0 مدیریت دارایی و تأمین مالی 2017-02-10 2051665481 24649 10.1016/j.rpor.2013.03.496 Journal long term tolerance of hypofractionated radiotherapy for prostate cancer Long term tolerance of hypofractionated radiotherapy for prostate cancer 2013 2013-06-01 168508312 18 0 0 0 Reports of Practical Oncology & Radiotherapy 2016-06-24 2798922264 26432 Book paradoxes of european foreign policy Paradoxes of European foreign policy 1997 1997-01-01 0 0 0 2018-05-07 2772001712 25503 a developing device and an image forming apparatus having a developing device A developing device, and an image forming apparatus having a developing device 2006 2006-04-19 0 0 0 2017-12-22 2584120037 21049 Journal original article the treatment of advanced chronic lower limb ischaemia with marrow stem cell autotransplantation ORIGINAL ARTICLE The treatment of advanced chronic lower limb ischaemia with marrow stem cell autotransplantation 2005 2005-01-01 164277434 63 10 351 360 0 27 27 Kardiologia Polska 2017-02-10 2051665483 20601 10.1016/j.humov.2013.03.003 Journal how much does the human medial gastrocnemius muscle contribute to ankle torques outside the sagittal plane How much does the human medial gastrocnemius muscle contribute to ankle torques outside the sagittal plane 2013 2013-08-01 Elsevier 166684315 32 4 753 767 46 19 19 Human Movement Science 2016-06-24 2798922270 24692 longitudinal studies in science education Longitudinal Studies in Science Education 2014 2014-01-01 4 0 0 2018-05-07 2772001715 24590 mute power capacitor Mute power capacitor 2015 2015-09-18 0 0 0 2017-12-22 2584120040 25818 Patent space optimized texture maps Space-optimized texture maps 2003 2003-02-10 0 0 0 2017-02-10 2051665485 22118 10.5151/chempro-14bmos-R0301-2 a new approach to the synthesis of natural product aripuanin A new approach to the synthesis of natural product Aripuanin 2013 2013-09-01 1 1 301 301 0 0 0 14th Brazilian Meeting on Organic Synthesis 2016-06-24 2798922274 22702 10.3233/jifs-161205 Journal a reliability and link analysis based method for mining domain experts in dynamic social networks A reliability and link analysis based method for mining domain experts in dynamic social networks 2018 2018-04-19 IOS Press 179157397 34 4 2061 2073 28 0 0 Journal of Intelligent and Fuzzy Systems 2018-05-07 2772001716 24385 10.5771/9783845285726-349 BookChapter vi quellen und literaturverzeichnis VI. QUELLEN- UND LITERATURVERZEICHNIS Föderalismus in historisch vergleichender Perspektive: Band 5: Einzelstaatliche Einflussnahme auf die Finanzpolitik im Deutschen Kaiserreich 2017 2017-01-01 Nomos Verlagsgesellschaft mbH & Co. KG 349 360 0 0 0 2017-12-22 2584120053 25808 Patent method and apparatus for controlling a video signal processing apparatus Method and apparatus for controlling a video signal processing apparatus 2003 2003-04-15 0 0 0 2017-02-10 2051665493 25361 10.1353/rah.2005.0052 Journal old tales in a new narrative rethinking the story of women and the american revolution Old Tales in a New Narrative: Rethinking the Story of Women and the American Revolution 2005 2005-01-01 Johns Hopkins University Press 182589707 33 3 309 313 0 0 0 Reviews in American History 2016-06-24 2798922289 25409 Book the good lie The Good Lie 2007 2007-10-31 0 0 0 2018-05-07 2772001733 22508 10.1080/00150193.2017.1361261 Journal tuning of structural and optical properties by sintering of multiferroic gdmno3 precursor Tuning of structural and optical properties by sintering of multiferroic GdMnO3 precursor 2017 2017-10-26 154037165 519 1 200 208 27 0 0 Ferroelectrics 2017-12-22 2584120055 23732 the helical antenna for handset design and phantom efiect The Helical Antenna for Handset Design and Phantom Efiect 2008 2008-01-01 2 1 1 2017-02-10 2051665504 21269 10.1109/16.3346 Journal characteristics of mosfets on large grain polysilicon films Characteristics of MOSFETs on large-grain polysilicon films 1988 1988-07-01 IEEE 162355128 35 7 923 928 16 34 55 IEEE Transactions on Electron Devices 2016-06-24 2798922290 23726 Book the snail and the ginger beer the singular case of donoghue v stevenson The Snail and the Ginger Beer: The Singular Case of Donoghue V Stevenson 2009 2009-12-01 0 1 1 2018-05-07 2772001737 27254 Patent bodenwanne fuer ein kraftfahrzeug floor pan for a motor vehicle Bodenwanne fuer ein kraftfahrzeug Floor pan for a motor vehicle 1988 1988-09-16 0 0 0 2017-12-22 2584120063 22778 10.1109/TC.2018.2860009 Journal scalable byzantine consensus via hardware assisted secret sharing Scalable Byzantine Consensus via Hardware-assisted Secret Sharing. 2016 2016-01-01 2595770078 26 0 0 arXiv: Cryptography and Security 2017-02-10 2051665505 17593 10.1016/j.cnsns.2008.05.003 Journal a similarity solution for laminar thermal boundary layer over a flat plate with a convective surface boundary condition A similarity solution for laminar thermal boundary layer over a flat plate with a convective surface boundary condition 2009 2009-04-01 Elsevier 39612629 14 4 1064 1068 8 349 529 Communications in Nonlinear Science and Numerical Simulation 2016-06-24 2798922293 24023 scientific letter reply lead preserving strategies for pacemaker pocket infection who when and how Scientific Letter Reply: Lead-preserving Strategies for Pacemaker Pocket Infection: Who, When and How? 2012 2012-01-01 13 0 0 2018-05-07 2772001748 24595 Patent vorrichtung zum herstellen eines gruppe iii nitrid basierten verbindungshalbleiters apparatus for manufacturing a group iii nitride based compound semiconductor Vorrichtung zum Herstellen eines Gruppe III-Nitrid basierten Verbindungshalbleiters Apparatus for manufacturing a Group III nitride based compound semiconductor 2007 2007-04-05 0 0 0 2017-12-22 2584120072 21276 10.1080/13561820.2016.1256871 Journal interprofessional education involving medical and pharmacy students during transitions of care Interprofessional education involving medical and pharmacy students during transitions of care 2017 2017-05-04 Taylor & Francis 40080443 31 3 404 406 7 2 2 Journal of Interprofessional Care 2017-02-10 2051665507 28656 10.1080/00690805.1974.10437777 atlas of israel cartography physical geography human and economic geography history published by survey of israel ministry of labour jerusalem and elsevier publishing co amsterdam 1970 2nd edition english 350 x 485 mm ii and 278 pages 121 tables 32 diagrams 602 maps 585 in colour u s 130 Atlas of Israel: Cartography, Physical Geography, Human and, Economic Geography, History, published by Survey of Israel, Ministry of Labour, Jerusalem and Elsevier Publishing Co., Amsterdam, 1970, 2nd Edition (English). 350 x 485 mm., ii and 278 pages, 121 tables, 32 diagrams, 602 maps (585 in colour). U.S.

The subventricular zone (SVZ) is one of the main niches of neural stem cells in the adult mammalian brain. Stem and precursor cells in this region are the source for neurogenesis and oligodendrogesis, mainly in the olfactory bulb and corpus callosum, respectively. The identification of the molecular components regulating the decision of these cells to differentiate or maintain an undifferentiated state is important in order to understand the modulation of neurogenic processes in physiological and pathological conditions. PPARs are a group of transcription factors, activated by lipid ligands, with important functions in cellular differentiation and proliferation in several tissues. In this work, we demonstrate that mouse adult neural precursor cells (NPCs), in situ and in vitro, express PPARβ/δ and PPARγ. Pharmacological activation of both PPARs isoforms induces proliferation and maintenance of the undifferentiated phenotype. Congruently, inhibition of PPARβ/δ and PPARγ results in a decrease of proliferation and loss of the undifferentiated phenotype. Interestingly, PPARγ regulates the level of EGFR in adult NPCs, concurrent with it is function described in embryonic NPCs. Furthermore, we describe for the first time that PPARβ/δ regulates SOX2 level in adult NPCs, probably through a direct transcriptional regulation, as we identified two putative PPAR response elements in the promoter region of Sox2. EGFR and SOX2 are key players in neural stem/precursor cells self-renewal. Finally, rosiglitazone, a PPARγ ligand, increases PPARβ/δ level, suggesting a possible cooperation between these two PPARs in the control of cell fate behavior. Our work contributes to the understanding of the molecular mechanisms associated to neural cell fate decision and places PPARβ/δ and PPARγ as interesting new targets of modulation of mammalian brain homeostasis.