Claudio Toniolo

New aspartame-like sweeteners containing L-(αMe)Phe

Abstract The [L-(αMe) Phe] 2 -analogue of aspartame was synthesized and analyzed by X-ray diffraction. This compound is as sweet as aspartame itself but far more stable at pH=4. Several N-protected analogues were synthesized. The N-formylcarbamoyl [L-(αMe Phe)] 2 -aspartame analogue is also sweet. The compounds fit well within the sweet perception model as developed by Temussi, Toniolo and coworkers.

CCDC 879903: Experimental Crystal Structure Determination

Related Article: Alessandro Donoli, Vanessa Marcuzzo, Alessandro Moretto, Marco Crisma, Claudio Toniolo, Roberta Cardena, Annalisa Bisello and Saverio Santi|2013|Biopolymers|100|14|doi:10.1002/bip.22197

A New Concept: A Peptide Monolayer for Accurate Positioning of Electroactive Probes at Close Distance from a Gold Surface

M. Caruso, E. Gatto, A. Palleschi, M. Scarselli, M. De Crescenzi, K. Wright, E. Longo, M. De Zotti, F. Formaggio, C. Toniolo, and M. Venanzi Department of Chemical Sciences and Technologies, University of Rome ‘Tor Vergata’, 00133, Rome, Italy; Department of Physics, University of Rome ‘Tor Vergata’, 00133, Rome, Italy; Institute Lavoisier de Versailles, UMR 8180, University of Versailles, 78035, Versailles, France; Department of Chemistry, University of Padova, 35131, Padova, Italy

Insight into peptide bond formation from 3D-structural chemistry

This chapter is an update of our contribution on the same topic published 20 years ago which dealt with the important issue of our still incomplete understanding of the reaction mechanisms involved in peptide bond formation and their implications for reactivity, regiospecificity, and propensity to racemize (or epimerize). The electronic and steric properties of five classes of C-carboxyl reactive derivatives of α-amino acid and peptides, namely fluorides, anhydrides, esters, azides, and amides are reviewed on the basis of the available 3D-structure information, mainly extracted from detailed X-ray diffraction analyses.

Monitoring peptide folding in membrane-active peptides: a time-resolved spectroscopic study

Reference EPFL-CONF-184380doi:10.1002/psc.2449View record in Web of Science Record created on 2013-02-27, modified on 2017-05-12No abstract is available for this article.

CCDC 250254: Experimental Crystal Structure Determination

Related Article: M.Crisma, A.Moretto, M.De Zotti, F.Formaggio, B.Kaptein, Q.B.Broxterman, C.Toniolo|2005|Biopolymers|80|279|doi:10.1002/bip.20181