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Clifford D. Bedford

SRI International

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Featured researches published by Clifford D. Bedford.

Synthetic Communications | 1985

Expedient Synthesis of Mono-Trimethylsilyl Hydroxylamine and Bis-Trimethylsilyl Hydroxylamine

Jeffrey C. Bottaro; Clifford D. Bedford; Allen Dodge

Abstract Mono and Bis-trimethylsilylhydroxylamine are conveniently prepared by similar procedures on an arbitrarily large scale, without risk or undue effort on the part of the experimenter.

Journal of Medicinal Chemistry | 1986

Nonquaternary cholinesterase reactivators. 3. 3(5)-Substituted 1,2,4-oxadiazol-5(3)-aldoximes and 1,2,4-oxadiazole-5(3)-thiocarbohydroximates as reactivators of organophosphonate-inhibited eel and human acetylcholinesterase in vitro.

Clifford D. Bedford; Robert A. Howd; Oliver D. Dailey; Alexi Miller; Harold W. Nolen; Richard A. Kenley; John R. Kern; John S. Winterle

Journal of Medicinal Chemistry | 1989

Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 2. Preparation and in vitro and in vivo evaluaton of 1-(alkoxymethyl)-2-[(hydroxyimino)methyl]-3-methylimidazolium halides for reactivation of organophosphorus-inhibited acetylcholinesterases

Clifford D. Bedford; Ralph N. Harris; Robert A. Howd; Dane A. Goff; Gary A. Koolpe; M. Petesch; Alexi Miller; Harold W. Nolen; H. A. Musallam

Journal of Organic Chemistry | 1986

Cleavage of methoxymethyl ethers with boron trichloride. A convenient, versatile preparation of chloromethyl ether derivatives

Dane A. Goff; Ralph N. Harris; Jeffrey C. Bottaro; Clifford D. Bedford

Journal of Medicinal Chemistry | 1984

Nonquaternary cholinesterase reactivators. 2. .alpha.-Heteroaromatic aldoximes and thiohydroximates as reactivators of ethyl methylphosphonyl-acetylcholinesterase in vitro

Richard A. Kenley; Clifford D. Bedford; Oliver D. Dailey; Robert A. Howd; Alexi Miller

Journal of Medicinal Chemistry | 1989

Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 3. Synthesis and evaluation of (alkenyloxy)-, (alkynyloxy)-, and (aralykyloxy)methyl quaternarized 2-[(hydroxyimino)methyl]-1-alkylimidazolium halides as reactivators and therapy for soman intoxication

Clifford D. Bedford; Ralph N. Harris; Robert A. Howd; Dane A. Goff; Gary A. Koolpe; M. Petesch; Irwin Koplovitz; Walter E. Sultan; H. A. Musallam

Journal of Medicinal Chemistry | 1984

Structure-activity relationships for reactivators of organophosphorus-inhibited acetylcholinesterase: quaternary salts of 2-[(hydroxyimino)methyl]imidazole

Clifford D. Bedford; Ralph N. Harris; Robert A. Howd; Alexi Miller; Harold W. Nolen; Richard A. Kenley

Journal of Medicinal Chemistry | 1991

Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 4. Effect of various side-chain substituents on therapeutic activity against anticholinesterase intoxication.

Dane A. Goff; Gary Koolpe; A. B. Kelson; H. M. Vu; D. L. Taylor; Clifford D. Bedford; H. A. Musallam; I. Koplovitz; Ralph N. Harris

Journal of Organic Chemistry | 1990

Reactions of 1-nitro-2-(trialkylsilyl)acetylenes

Jeffrey C. Bottaro; Robert J. Schmitt; Clifford D. Bedford; Richard Gilardi; Clifford George

Journal of Organic Chemistry | 1987

Nonacidic nitration of secondary amines

Jeffrey C. Bottaro; Robert J. Schmitt; Clifford D. Bedford

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Robert A. Howd

SRI International

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Jeffrey C. Bottaro

University at Buffalo

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Dane A. Goff

SRI International

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Richard A. Kenley

SRI International

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Ralph N. Harris

SRI International

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Robert J. Schmitt

SRI International

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Gary Koolpe

SRI International

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Allen Dodge

SRI International

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Gary A. Koolpe

University of Washington

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Clifford George

United States Naval Research Laboratory

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