Clinton W. Gray

Silent hemoglobin alpha genes in apes: potential source of thalassemia.

Small quantities of unusual hemoglobins were found in 1 of 37 chimpanzees and 2 of 6 gorillas. In each genus these hemoglobins contain unique α chains that differ from the ordinary by eight to nine scattered amino acid changes. The unusual chains arise from a hitherto undetected hemoglobin 3α locus. No 3α products are found in most apes; accordingly, 3α is considered synthetically inactive in all but a few reversion mutants. Indirect evidence that the inactive 3α locus is juxtaposed to an active α locus together with the supposition that 3α exists in man provides a setting wherein thalassemia might be produced by nonhomologous recombination between two loci.

Positive contrast peritoneography and herniography in primate animals. With special reference to indirect inquinal hernias

In a number of primate animals contrast medium was injected intraperitoneally to diagnose hernias as well as evaluate the normal anatomical relationships. The technical considerations are discussed. Contrast herniography and peritoneography appear useful under certain clinical circumstances.