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Dive into the research topics where Colin I. O’Donnell is active.

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Featured researches published by Colin I. O’Donnell.


Journal of the American College of Cardiology | 2015

1-year risk-adjusted mortality and costs of percutaneous coronary intervention in the Veterans Health Administration: insights from the VA CART Program.

P. Michael Ho; Colin I. O’Donnell; Steven M. Bradley; Gary K. Grunwald; Christian D. Helfrich; Michael K. Chapko; Chuan Fen Liu; Thomas M. Maddox; Thomas T. Tsai; Robert L. Jesse; Stephan D. Fihn; John S. Rumsfeld

BACKGROUND There is significant interest in measuring health care value, but this concept has not been operationalized in specific patient cohorts. The longitudinal outcomes and costs for patients after percutaneous coronary intervention (PCI) provide an opportunity to measure an aspect of health care value. OBJECTIVES This study evaluated variations in 1-year outcomes (risk-adjusted mortality) and risk-standardized costs of care for all patients undergoing PCI in the Veterans Affairs (VA) system from 2007 to 2010. METHODS This retrospective cohort study evaluated all veterans undergoing PCI at any of 60 hospitals in the VA health care system, using data from the national VA Clinical Assessment, Reporting, and Tracking (CART) program. Primary outcomes were 1-year mortality and costs following PCI. Risk-standardized mortality and cost ratios were calculated, adjusting for cardiac and noncardiac comorbidities. RESULTS A median of 261 PCIs were performed in the 60 hospitals during the study period. Median 1-year unadjusted hospital mortality rate was 6.13%. Four hospitals were significantly above the 1-year risk-standardized median mortality rate, with median mortality ratios ranging from 1.23 to 1.28. No hospitals were significantly below median mortality. Median 1-year total unadjusted hospital costs were


Circulation | 2014

Patient Access and 1-Year Outcomes of Percutaneous Coronary Intervention Facilities With and Without On-Site Cardiothoracic Surgery Insights From the Veterans Affairs (VA) Clinical Assessment, Reporting, and Tracking (CART) Program

Thomas M. Maddox; Maggie A. Stanislawski; Colin I. O’Donnell; Steven M. Bradley; P. Michael Ho; Thomas T. Tsai; Adhir Shroff; Bernadette Speiser; Robert J. Jesse; John S. Rumsfeld

46,302 per patient. There were 16 hospitals above and 19 hospitals below the risk-standardized median cost, with risk-standardized ratios ranging from 0.45 to 2.09, reflecting a much larger magnitude of variability in costs than in mortality. CONCLUSIONS There is much smaller variation in 1-year risk adjusted mortality than in risk-standardized costs after PCI in the VA. These findings suggest that there are opportunities to improve PCI value by reducing costs without compromising outcomes. This approach to evaluating outcomes and costs together may be a model for other health systems and accountable care organizations interested in operationalizing value measurement.


Circulation | 2015

Facility-Level Variation in Hospitalization, Mortality, and Costs in the 30 Days After Percutaneous Coronary Intervention: Insights on Short-Term Healthcare Value From the Veterans Affairs Clinical Assessment, Reporting, and Tracking System (VA CART) Program.

Steven M. Bradley; Colin I. O’Donnell; Gary K. Grunwald; Chuan Fen Liu; Paul L. Hebert; Thomas M. Maddox; Robert L. Jesse; Stephan D. Fihn; John S. Rumsfeld; P. Michael Ho

Background— The safety of percutaneous coronary intervention (PCI) at medical facilities without on-site cardiothoracic (CT) surgery has been established in clinical trials. However, the comparative effectiveness of this strategy in real-world practice, including impact on patient access and outcomes, is uncertain. The Veterans Affairs (VA) health care system has used this strategy, with strict quality oversight, since 2005, and can provide insight into this question. Methods and Results— Among 24 387 patients receiving PCI at VA facilities between October 2007 and September 2010, 6616 (27.1%) patients underwent PCI at facilities (n=18) without on-site CT surgery. Patient drive time (as a proxy for access), procedural complications, 1-year mortality, myocardial infarction, and rates of subsequent revascularization procedures were compared by facility. Results were stratified by procedural indication (ST–segment-elevation myocardial infarction versus non–ST–segment-elevation myocardial infarction/unstable angina versus elective) and PCI volume. With the inclusion of PCI facilities without on-site CT surgery, median drive time for patients treated at those facilities decreased by 90.8 minutes ( P <0.001). Procedural need for emergent coronary artery bypass graft and mortality rates were low and similar between facilities. Adjusted 1-year mortality and myocardial infarction rates were similar between facilities (hazard ratio in PCI facilities without relative to those with on-site CT surgery, 1.02; 95% confidence interval, 0.87–1.2), and not modified by either PCI indication or PCI volume. Subsequent revascularization rates were higher at sites without on-site CT surgery facilities (hazard ratio, 1.21; 95% confidence interval, 1.03–1.42). Conclusions— This study suggests that providing PCI facilities without on-site CT surgery in an integrated health care system with quality oversight improves patient access without compromising procedural or 1-year outcomes. # CLINICAL PERSPECTIVE {#article-title-22}Background— The safety of percutaneous coronary intervention (PCI) at medical facilities without on-site cardiothoracic (CT) surgery has been established in clinical trials. However, the comparative effectiveness of this strategy in real-world practice, including impact on patient access and outcomes, is uncertain. The Veterans Affairs (VA) health care system has used this strategy, with strict quality oversight, since 2005, and can provide insight into this question. Methods and Results— Among 24 387 patients receiving PCI at VA facilities between October 2007 and September 2010, 6616 (27.1%) patients underwent PCI at facilities (n=18) without on-site CT surgery. Patient drive time (as a proxy for access), procedural complications, 1-year mortality, myocardial infarction, and rates of subsequent revascularization procedures were compared by facility. Results were stratified by procedural indication (ST–segment-elevation myocardial infarction versus non–ST–segment-elevation myocardial infarction/unstable angina versus elective) and PCI volume. With the inclusion of PCI facilities without on-site CT surgery, median drive time for patients treated at those facilities decreased by 90.8 minutes (P<0.001). Procedural need for emergent coronary artery bypass graft and mortality rates were low and similar between facilities. Adjusted 1-year mortality and myocardial infarction rates were similar between facilities (hazard ratio in PCI facilities without relative to those with on-site CT surgery, 1.02; 95% confidence interval, 0.87–1.2), and not modified by either PCI indication or PCI volume. Subsequent revascularization rates were higher at sites without on-site CT surgery facilities (hazard ratio, 1.21; 95% confidence interval, 1.03–1.42). Conclusions— This study suggests that providing PCI facilities without on-site CT surgery in an integrated health care system with quality oversight improves patient access without compromising procedural or 1-year outcomes.


Circulation | 2015

Facility-Level Variation in Hospitalization, Mortality, and Costs in the 30 Days After Percutaneous Coronary Intervention

Steven M. Bradley; Colin I. O’Donnell; Gary K. Grunwald; Chuan Fen Liu; Paul L. Hebert; Thomas M. Maddox; Robert L. Jesse; Stephan D. Fihn; John S. Rumsfeld; P. Michael Ho

Background— Policies to reduce unnecessary hospitalizations after percutaneous coronary intervention (PCI) are intended to improve healthcare value by reducing costs while maintaining patient outcomes. Whether facility-level hospitalization rates after PCI are associated with cost of care is unknown. Methods and Results— We studied 32 080 patients who received PCI at any 1 of 62 Veterans Affairs hospitals from 2008 to 2011. We identified facility outliers for 30-day risk-standardized hospitalization, mortality, and cost. Compared with the risk-standardized average, 2 hospitals (3.2%) had a lower-than-expected hospitalization rate, and 2 hospitals (3.2%) had a higher-than-expected hospitalization rate. We observed no statistically significant variation in facility-level risk-standardized mortality. The facility-level unadjusted median per patient 30-day total cost was


Human Heredity | 2009

A Likelihood Model That Accounts for Censoring Due to Fetal Loss Can Accurately Test the Effects of Maternal and Fetal Genotype on the Probability of Miscarriage

Colin I. O’Donnell; Charles J. Glueck; Tasha E. Fingerlin; Deborah H. Glueck

23 820 (interquartile range,


Journal of the American College of Cardiology | 2016

PERCUTANEOUS CORONARY INTERVENTION IN NATIVE CORONARY ARTERIES VERSUS BYPASS GRAFTS IN PATIENTS WITH PRIOR CORONARY ARTERY BYPASS GRAFT SURGERY: INSIGHTS FROM THE VETERANS AFFAIRS CLINICAL ASSESMENT REPORTING AND TRACKING PROGRAM

Emmanouil S. Brilakis; Colin I. O’Donnell; William F. Penny; Ehrin J. Armstrong; Thomas C. Tsai; Thomas M. Maddox; Subhash Banerjee; Sunil V. Rao; Santiago Garcia; Brahmajee K. Nallamothu; Kendrick A. Shunk; Kreton Mavromatis; Gary K. Grunwald; Deepak L. Bhatt

19 604–


Circulation | 2016

Response to Letter Regarding Article, “Facility Level Variation in Hospitalization, Mortality, and Costs in the 30 Days After Percutaneous Coronary Intervention: Insights on Short-Term Healthcare Value From the Veterans Affairs Clinical Assessment, Reporting, and Tracking System (VA CART) Program”

Steven M. Bradley; Colin I. O’Donnell; Gary K. Grunwald; Chuan Fen Liu; Paul L. Hebert; Thomas M. Maddox; Robert L. Jesse; Stephan D. Fihn; John S. Rumsfeld; P. Michael Ho

29 958). Compared with the risk-standardized average, 17 hospitals (27.4%) had lower-than-expected costs, and 14 hospitals (22.6%) had higher-than-expected costs. At the facility level, the index PCI accounted for 83.1% of the total cost (range, 60.3%–92.2%), whereas hospitalization after PCI accounted for only 5.8% (range, 2.0%–12.7%) of the 30-day total cost. Facilities with higher hospitalization rates were not more expensive (Spearman &rgr;=0.16; 95% confidence interval, −0.09 to 0.39; P=0.21). Conclusions— In this national study, hospitalizations in the 30 day after PCI accounted for only 5.8% of 30-day cost, and facility-level cost was not correlated with hospitalization rates. This challenges the focus on reducing hospitalizations after PCI as an effective means of improving healthcare value. Opportunities remain to improve PCI value by reducing the variation in total cost of PCI without compromising patient outcomes.Background— Policies to reduce unnecessary hospitalizations after percutaneous coronary intervention (PCI) are intended to improve healthcare value by reducing costs while maintaining patient outcomes. Whether facility-level hospitalization rates after PCI are associated with cost of care is unknown. Methods and Results— We studied 32 080 patients who received PCI at any 1 of 62 Veterans Affairs hospitals from 2008 to 2011. We identified facility outliers for 30-day risk-standardized hospitalization, mortality, and cost. Compared with the risk-standardized average, 2 hospitals (3.2%) had a lower-than-expected hospitalization rate, and 2 hospitals (3.2%) had a higher-than-expected hospitalization rate. We observed no statistically significant variation in facility-level risk-standardized mortality. The facility-level unadjusted median per patient 30-day total cost was


Circulation | 2015

Facility-Level Variation in Hospitalization, Mortality, and Costs in the 30 Days After Percutaneous Coronary InterventionCLINICAL PERSPECTIVE

Steven M. Bradley; Colin I. O’Donnell; Gary K. Grunwald; Chuan Fen Liu; Paul L. Hebert; Thomas M. Maddox; Robert L. Jesse; Stephan D. Fihn; John S. Rumsfeld; P. Michael Ho

23 820 (interquartile range,


Circulation | 2014

Patient Access and 1-Year Outcomes of Percutaneous Coronary Intervention Facilities With and Without On-Site Cardiothoracic Surgery

Thomas M. Maddox; Maggie A. Stanislawski; Colin I. O’Donnell; Steven M. Bradley; P. Michael Ho; Thomas T. Tsai; Adhir Shroff; Bernadette Speiser; Robert J. Jesse; John S. Rumsfeld

19 604–


Circulation | 2014

Patient Access and 1-Year Outcomes of Percutaneous Coronary Intervention Facilities With and Without On-Site Cardiothoracic SurgeryCLINICAL PERSPECTIVE

Thomas M. Maddox; Maggie A. Stanislawski; Colin I. O’Donnell; Steven M. Bradley; P. Michael Ho; Thomas T. Tsai; Adhir Shroff; Bernadette Speiser; Robert J. Jesse; John S. Rumsfeld

29 958). Compared with the risk-standardized average, 17 hospitals (27.4%) had lower-than-expected costs, and 14 hospitals (22.6%) had higher-than-expected costs. At the facility level, the index PCI accounted for 83.1% of the total cost (range, 60.3%–92.2%), whereas hospitalization after PCI accounted for only 5.8% (range, 2.0%–12.7%) of the 30-day total cost. Facilities with higher hospitalization rates were not more expensive (Spearman ρ=0.16; 95% confidence interval, −0.09 to 0.39; P =0.21). Conclusions— In this national study, hospitalizations in the 30 day after PCI accounted for only 5.8% of 30-day cost, and facility-level cost was not correlated with hospitalization rates. This challenges the focus on reducing hospitalizations after PCI as an effective means of improving healthcare value. Opportunities remain to improve PCI value by reducing the variation in total cost of PCI without compromising patient outcomes. # CLINICAL PERSPECTIVE {#article-title-37}Background —Policies to reduce unnecessary hospitalizations after PCI are intended to improve healthcare value by reducing costs while maintaining patient outcomes. Whether facility-level hospitalization rates after PCI are associated with cost of care is unknown. Methods and Results —We studied 32,080 patients who received PCI at any one of 62 VA hospitals from 2008 to 2011. We identified facility outliers for 30-day risk-standardized hospitalization, mortality and cost. Compared with the risk-standardized average, 2 (3.2%) hospitals had a lower than expected hospitalization rate and 2 (3.2%) hospitals had a higher than expected hospitalization rate. We observed no statistically significant variation in facility-level risk-standardized mortality. The facility-level unadjusted median per patient 30-day total cost was

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Thomas M. Maddox

Washington University in St. Louis

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John S. Rumsfeld

University of Colorado Denver

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P. Michael Ho

University of Colorado Denver

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Steven M. Bradley

University of Colorado Denver

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Chuan Fen Liu

University of Washington

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Robert L. Jesse

Virginia Commonwealth University

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