Colleen M. Cook
Westmead Hospital
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Featured researches published by Colleen M. Cook.
British Journal of Obstetrics and Gynaecology | 1985
Brian J. Trudinger; Warwick B. Giles; Colleen M. Cook; John Bombardieri; Lee Collins
Summary. Since the umbilical arteries carry fetal blood to the placenta we studied flow velocity waveforms in these vessels with a simple continuous wave Doppler system to assess placental blood flow. The ratio of peak systolic to least diastolic (A/B) flow velocity was measured as an index of placental flow resistance. In 15 normal pregnancies there was a small but significant decrease in this ratio through the last trimester. The A/B ratio was measured on 436 occasions in 168 high‐risk pregnancies. In 32 of 43 fetuses subsequently shown to be small for gestational age there was an increase in placental flow resistance with reduced, absent or even reversed flow in diastole. This finding was also present in the one fetus which died in utero. Serial studies in patients with fetal compromise indicated increasing flow resistance, a reverse of the normal trend. These results were not available to the clinician yet of 24 fetuses born before 32 weeks 13 had a high A/B ratio, and all of them were born electively. Maternal hypertension was associated with an increase in fetal placental flow resistance. The umbilical artery A/B ratio provides a new and non‐invasive measure of fetoplacental blood flow resistance.
British Journal of Obstetrics and Gynaecology | 1985
Brian J. Trudinger; Warwick B. Giles; Colleen M. Cook
Summary. A simple continuous wave Doppler ultrasound system for recording arterial flow velocity waveforms in branches of the uterine artery in the placental bed is described. Twelve normal pregnancies were studied serially from 20 weeks to delivery. The diastolic flow velocity expressed as a percentage of the systolic provides an index of downstream vascular bed resistance and perfusion. This always exceeded 50% in normal pregnancy and there was a small increase with gestational age indicative of a decreasing flow resistance. Of the 91 complicated pregnancies, studied because of potential uteroplacental insufficiency and fetal risk, 25 resulted in the birth of an infant small‐for‐gestational‐age. In 15 the uterine artery flow velocity waveform revealed a pattern of low diastolic flow velocity. It is postulated that these represent a subgroup of growth‐retarded fetuses in whom there is reduced uterine artery perfusion. Reduced uterine artery diastolic flow velocity in these patients was associated with reduced umbilical artery diastolic flow velocity on the fetal side of the placenta. In contrast the 10 small‐for‐gestation infants associated with normal uterine artery waveforms suggest a primary fetal cause. Twelve patients with severe hypertensive disease of pregnancy were studied. Nine were associated with reduced uterine artery diastolic flow velocity (reduced uterine artery perfusion) consistent with vasospasm in the branches of the uterine artery in the placental bed.
British Journal of Obstetrics and Gynaecology | 1986
Brian J. Trudinger; Colleen M. Cook; L. Jones; Warwick B. Giles
Summary. Antenatal fetal heart rate monitoring was compared with the study of umbilical artery flow velocity waveforms for the recognition of fetal compromise in 170 patients considered at high fetal risk. In 53 patients the infant had a 5‐min Apgar score of <7 and/or a birthweight < the 10th centile of weight for gestation. Fetal heart rate traces were classified as reactive or non‐reactive and also assessed with a modified Fischer score. The systolic/diastolic A/B ratio was measured in the umbilical artery waveform. Fetal compromise was more efficiently recognized by study of the umbilical artery waveforms. The sensitivity of assessment by umbilical artery waveforms was 60% compared with 17% and 36% respectively, for the two methods of scoring fetal heart rate traces. This was not associated with an increase in false‐positive results as the predictive value of both positive (64% compared with 69 and 58%) and negative (83% compared with 72 and 75%) results was similar when umbilical artery waveform analysis was compared with the two methods of scoring fetal heart rate traces. Specificity was also similar (85% compared with 97 and 88%).
British Journal of Obstetrics and Gynaecology | 1985
Warwick B. Giles; Brian J. Trudinger; Colleen M. Cook
Summary. The umbilical artery flow velocity‐time waveforms were studied in 76 twin pregnancies. The ratio of peak systolic (A) to least diastolic (El) velocity was calculated for each fetus as an index of umbilical placental flow resistance. Seventy‐one sets of twins were studied within 14 days before delivery. In 65 cases both twins were alive at the time of study. In 32 pregnancies both fetuses were of birthweight appropriate for gestational age (AGA) and had A/B ratios within the normal singleton range. In 33 pregnancies one or both of the liveborn infants were small for gestational age (SGA) and in 78% of these at least one fetus had an elevated A/B ratio. Discordancy in birthweight and A/B ratio was associated with growth retardation. Clinically manifest twin‐to‐twin transfusions occurred in five of the ten pregnancies resulting in an SGA infant (eight with discordant weight) associated with a normal and concordant A/B ratio. Two twin‐to‐twin transfusions were associated with perinatal death. The placentas were examined in 61 patients. In 43 dichorionic pairs the A/B ratio was elevated in 12 of the 18 where there was at least one SGA infant. There was a greater incidence of growth retardation in the monochorionic pairs (12 of 18). Only seven of these were identified by an elevated A/B ratio. In 10 of these 18 pairs vascular anastomoses were demonstrated on placental inspection and in a further two there was evidence of twin‐to‐twin transfusion by haemoglobin discrepancy. Twin pregnancy may result in the birth of a small‐for‐dates infant because of intrauterine growth retardation or twin‐to‐twin transfusion. An abnormally elevated A/B ratio identifies growth retardation. In twin‐to‐twin transfusion the A/B ratio of the two fetuses is similar (crossed circulation) yet difference in size may be seen on ultrasound measurement.
British Journal of Obstetrics and Gynaecology | 1985
Brian J. Trudinger; Colleen M. Cook
Summary. Flow velocity waveforms from the umbilical artery and branches of the uterine artery in the placental bed were recorded using continuous wave Doppler ultrasound. The records of 26 patients with pregnancy complicated by major fetal abnormality were reviewed to determine the changes of a primary fetal disturbance. The systolic/diastolic (A/B) ratio was used as an index of blood flow resistance. In 13 of the 26 patients the umbilical artery waveform systolic/diastolic ratio was high. It is postulated that in these patients there is a process of obliteration of small arteries in the placenta that is triggered by the abnormal fetus. In all patients the uterine artery waveform was normal. In seven of these 13 patients the infant had a birthweight > 10th centile. Placental weights were examined. A small placenta expressed as either low weight for gestational age or low placental/feta1 weight ratio was associated with a normal umbilical artery waveform. It is suggested that fetuses in these groups have a low growth potential. In contrast a high placental/fetal weight ratio was associated with an abnormal umbilical artery waveform pattern.
British Journal of Obstetrics and Gynaecology | 1987
Warwick B. Giles; Alan A. Young; Kenneth J. Howlin; Colleen M. Cook; Brian J. Trudinger
A Mauritian woman aged 34 years, para 3+3, presented to the antenatal clinic with 6 week? amenorrhoea. She had been hypertensive from the age of 18 years and investigations undertaken in Mauritius and Germany had revealed no apparent cause for the hypertension. She had been treated previously with alphamethyldopa 250 mg and prazosin 1 mg twice daily with good control of her blood pressure (prazosin had been discontinued on diagnosis of this pregnancy). The past obstetric history was poor. After a spontaneous miscarriage at 18 weeks, the next three pregnancies were undertaken with cervical ligatures /rz situ. Two liveborn children (one at term, and one at 32 weeks after 5 weeks hospitalization for hypertension) and an intrauterine death at 24 weeks resulted. After she migrated to Australia the patient had two further pregnancies both therapeutically terminated in the first trimester. On examination she was 150cm tall and weighed 57.5 kg. Her blood pressure (arm) was easily recorded at 130/80 mmHg and proteinuria was absent. There was asystolicejectionmurmur at the left sternal edge and no evidence of cardiac failure, Femoral pulses were difficult to feel suggesting a diagnosis of coarctation of the aorta. Pelvic examination revealed a pregnant uterus consistent with dates. The cervix admitted a finger tip through the internal 0s and was 2 cm in length.
Obstetrics & Gynecology | 1988
Warwick Giles; Brian J. Trudinger; Colleen M. Cook; Anita Connelly
Obstetrical & Gynecological Survey | 1987
Brian J. Trudinger; Warwick Giles; Colleen M. Cook; Anita Connelly; Rosemary S. Thompson
Gynakologisch-geburtshilfliche Rundschau | 1987
Brian J. Trudinger; Colleen M. Cook
Gynakologisch-geburtshilfliche Rundschau | 1986
Brian J. Trudinger; Warwick B. Giles; Colleen M. Cook