Constantina O. Moraiti

Tibial rotation is not restored after ACL reconstruction with a hamstring graft.

Recent research suggests ACL reconstruction does not restore tibial rotation to normal levels during high demand activities when a bone-patellar tendon-bone graft is used. We asked if an alternative graft, the semitendinosus-gracilis (ST/G) tendon graft, could restore tibial rotation during a high demand activity. Owing to its anatomic similarity with the normal ACL we hypothesized the ST/G graft could restore excessive tibial rotation to normal healthy levels along with a successful reinstatement of the clinical stability of the knee. We assessed tibial rotation in vivo, using gait analysis. We compared the knees of ACL reconstructed patients with an ST/G graft to their intact contralateral and healthy controls during a pivoting task that followed a stair descent. We also evaluated knee stability after ACL reconstruction with standard clinical tests. ACL reconstruction with the ST/G graft and with current techniques did not restore tibial rotation to previous physiological levels during an activity with increased rotational loading at the knee, although abnormal anteroposterior (AP) tibial translation was restored.

Tibial rotation in anterior cruciate ligament (ACL)-deficient and ACL-reconstructed knees: a theoretical proposition for the development of osteoarthritis.

Excessive tibial rotation has been documented in anterior cruciate ligament (ACL) deficiency during walking. ACL reconstruction has been unable to correct this abnormality in activities that are more demanding than walking and involve both anterior and rotational loading of the knee. These findings persist regardless of graft selection for the ACL reconstruction (bone-patellar tendon-bone or semitendinosus gracilis). Based on this research work, we propose a theoretical perspective for the development of osteoarthritis in both the ACL-deficient and the ACL-reconstructed knee. We propose that excessive tibial rotation will lead to abnormal loading of the cartilage areas that are not commonly loaded in the healthy knee. Over time, this abnormal loading will lead to osteoarthritis. We hypothesise that the development of new surgical procedures and grafts, such as a more horizontally oriented femoral tunnel or a double-bundle ACL reconstruction, could possibly restore tibial rotation to normal levels and prevent future knee pathology. However, in vivo gait analysis studies are needed to examine the effects of these surgical procedures on tibial rotation. Prospective in vivo and in vitro studies are also necessary to verify or refute our theoretical proposition for the development of osteoarthritis.

A Novel Approach to Measure Variability in the Anterior Cruciate Ligament Deficient Knee During Walking: The Use of the Approximate Entropy in Orthopaedics

Objective. The evaluation of variability of biological rhythmic activities through measures such as Approximate Entropy (ApEn) has provided important information regarding pathology in disciplines such as cardiology and neurology. This research lead to the “loss of complexity hypothesis” where decreased variability is associated with loss of healthy flexibility rendering the system more rigid and unable to adapt to stresses. ApEn as a measure of variability and complexity, correlates well with pathology while, in some cases, it is predictive of subsequent clinical changes. The study of human gait could benefit from the application of ApEn since it is also a rhythmical oscillation. Our aim was to assess the variability of the ACL deficient knee, since ACL rupture is a common musculoskeletal injury and is accompanied by altered gait patterns and future pathology in the joint. We hypothesized that the ACL deficient knee will exhibit more regular and less variable walking patterns than the contralateral intact knee. Methods. Ten subjects with unilateral deficiency walked on a treadmill at their self-selected speed, 20% faster, and 20% slower, while kinematics were collected (50 Hz) from 80 consecutive strides for each condition. The ApEn of the resulted knee joint flexion-extension time series was calculated. Results. Significantly smaller ApEn values were found in the ACL deficient knee when compared with the contralateral intact (F = 5.57, p = 0.022), for all speeds. ApEn values significantly increased (F = 5.79, p = 0.005) with increases in walking speed. Conclusions. The altered properties of the ACL deficient knee, which exhibits more regular and less variable patterns than the contralateral intact knee, may decrease the adaptability of the system rendering it less able to adjust to perturbations. This could explain the increased future pathology found in the deficient knee. ApEn can be an important tool in assessing pathology and therapeutic interventions in orthopaedics.

Follow-up evaluation 2 years after ACL reconstruction with bone-patellar tendon-bone graft shows that excessive tibial rotation persists.

ObjectiveTo investigate in vivo if the increased tibial rotation found in anterior cruciate ligament (ACL)-deficient patients before surgery is restored 2 years after the reconstruction, during 2 high-demanding activities. DesignProspective follow-up study. SettingA gait analysis laboratory. ParticipantsNine subjects with unilateral ACL rupture, reconstructed with a bone–patellar tendon–bone (BPTB) graft, and 10 healthy control subjects. InterventionsAll the ACL-deficient patients underwent a unilateral ACL reconstruction after prereconstruction data acquisition. Main Outcome MeasurementsUsing a 6-camera motion analysis system, kinematics were collected as subjects (1) descended from a stair and, after foot contact, pivoted on the landing leg at 90°; and (2) jumped from a platform, landed with both feet on the ground and, after foot contact, pivoted on the right or left leg at 90° in a similar fashion. The dependent variable examined was the maximum range of motion of tibial rotation during the pivoting period. ResultsFor both activities, no significant differences were found between the control healthy knee and the intact knee of the patient group before and 2 years after the ACL reconstruction. Significant differences were found between the control healthy knee and the affected knee of the patients group for both activities, both before and 2 years after the ACL reconstruction. ConclusionThe increased tibial rotation found in the ACL-deficient knees was not restored with reconstruction using a BPTB graft, even 2 years postoperatively. The authors propose that this excessive tibial rotation over time may lead to further deterioration of the knee resulting from abnormal loading at areas of the cartilage that are not commonly loaded in a healthy knee.

ACL deficiency affects stride-to-stride variability as measured using nonlinear methodology.

Previous studies suggested that the small fluctuations present in movement patterns from one stride to the next during walking can be useful in the investigation of various pathological conditions. Previous studies using nonlinear measures have resulted in the development of the “loss of complexity hypothesis” which states that disease can affect the variability and decrease the complexity of a system, rendering it less able to adjust to the ever changing environmental demands. The nonlinear measure of the Lyapunov Exponent (LyE) has already been used for the assessment of stride-to-stride variability in the anterior cruciate ligament (ACL) deficient knee in comparison to the contralateral intact knee. However, there is biomechanical evidence that after ACL rupture, adaptations are also present in the contralateral intact knee. Thus, our goal was to investigate stride-to-stride variability in the ACL deficient knee as compared to a healthy control knee. Seven subjects with unilateral ACL deficiency and seven healthy controls walked at their self-selected speed on a treadmill, while three-dimensional knee kinematics was collected for 80 consecutive strides. A nonlinear measure, the largest LyE was calculated from the resulted knee joint flexion-extension data of both groups. Larger LyE values signify increased variability and increased sensitivity to initial conditions. Our results showed that the ACL deficient group exhibited significantly less variable walking patterns than the healthy control. These changes are not desirable because they reflect decreases in system’s complexity, which indicates narrowed functional responsiveness, according to the “loss of complexity hypothesis.” This may be related with the increased future pathology found in ACL deficient patients. The methods used in the present paper showed great promise to assess the gait handicap in knee injured patients.

Anterior cruciate ligament reconstruction results in alterations in gait variability

INTRODUCTION The temporal structure of gait variability has shown that healthy human gait exhibits long-range correlations and deterministic properties which allow the neuromuscular system to be flexible and adaptable to stresses. Pathology results in deterioration of these properties. We examined structure of gait variability after ACL reconstruction with either BPTB or quadrupled ST/G tendon autografts. METHODS Six patients with BPTB reconstruction, six with ST/G reconstruction and six healthy controls walked on a treadmill at their self-selected pace. Two minutes of continuous kinematic data were recorded with a 6-camera optoelectronic system. The nonlinear measure of the largest Lyapunov Exponent (LyE) was estimated from the knee flexion-extension time series from 100 continuous walking strides to assess the structure of gait variability. RESULTS The reconstructed limbs in both reconstructed groups exhibited significantly larger LyE values than the control limbs (p<0.05), even though clinical outcomes indicated complete restoration. No significant differences were found between the two autografts. In addition, the intact contralateral leg produced significant higher LyE values as compared with the ACL-reconstructed leg in both groups. No interaction was found. DISCUSSION The larger LyE values indicate that the reconstructed knees of both reconstructed groups exhibit more divergence in the movement trajectories during gait. The larger Lye values found in the intact leg in both reconstructed groups could be interpreted as a compensatory mechanism. However, the increased divergence found in both limbs may present an alternative explanation for the impaired neuromuscular performance and increased susceptibility to future pathology, which is supported by the increased amount of osteoarthritis found in ACL-reconstructed patients.

The Effect of Anterior Cruciate Ligament Reconstruction on Stride-to-Stride Variability

PURPOSE The purpose of our study was to investigate the functional outcome after anterior cruciate ligament (ACL) reconstruction using bone-patellar tendon-bone (BPTB) and quadrupled semitendinosus and gracilis tendon (ST/G) autografts by evaluating stride-to-stride variability. METHODS Six patients with BPTB and 6 patients with STG ACL reconstruction, 2 years postoperatively, and 6 healthy control subjects walked on a treadmill at a self-selected pace while 2 minutes of continuous kinematic data were recorded with a 6-camera optoelectronic system. Stride-to-stride variability was calculated from the knee flexion/extension data using the nonlinear measure of approximate entropy, which estimates the regularity of movement patterns over time. RESULTS ACL reconstruction affects stride-to-stride variability. Both the BPTB and the ST/G groups had significantly larger approximate entropy values than the healthy controls. No differences were found between the BPTB and the ST/G approximate entropy values. CONCLUSIONS After ACL reconstruction using either BPTB or quadrupled ST/G, there is increased gait variability as compared to healthy individuals. This could be caused by the altered neuromuscular activity found in ACL-reconstructed limbs. LEVEL OF EVIDENCE Level III, case control study.

New insights into anterior cruciate ligament deficiency and reconstruction through the assessment of knee kinematic variability in terms of nonlinear dynamics

PurposeInjuries to the anterior cruciate ligament (ACL) occur frequently, particularly in young adult athletes, and represent the majority of the lesions of knee ligaments. Recent investigations suggest that the assessment of kinematic variability using measures of nonlinear dynamics can provide with important insights with respect to physiological and pathological states. The purpose of the present article was to critically review and synthesize the literature addressing ACL deficiency and reconstruction from a nonlinear dynamics standpoint.MethodsA literature search was carried out in the main medical databases for studies published between 1990 and 2010.ResultsSeven studies investigated knee kinematic variability in ACL patients. Results provided support for the theory of “optimal movement variability”. Practically, loss below optimal variability is associated with a more rigid and very repeatable movement pattern, as observed in the ACL-deficient knee. This is a state of low complexity and high predictability. On the other hand, increase beyond optimal variability is associated with a noisy and irregular movement pattern, as found in the ACL-reconstructed knee, regardless of which type of graft is used. This is a state of low complexity and low predictability. In both cases, the loss of optimal variability and the associated high complexity lead to an incapacity to respond appropriately to the environmental demands, thus providing an explanation for vulnerability to pathological changes following injury.ConclusionSubtle fluctuations that appear in knee kinematic patterns provide invaluable insight into the health of the neuromuscular function after ACL rupture and reconstruction. It is thus critical to explore them in longitudinal studies and utilize nonlinear measures as an important component of post-reconstruction medical assessment.Level of evidenceII.

Comparison of Functional Gains After Arthroscopic Rotator Cuff Repair in Patients Over 70 Years of Age Versus Patients Under 50 Years of Age: A Prospective Multicenter Study

PURPOSE To assess rotator cuff rupture characteristics and evaluate healing and the functional outcome after arthroscopic repair in patients older than 70 years versus patients younger than 50 years. METHODS We conducted a multicenter, prospective, comparative study of 40 patients younger than 50 years (group A) and 40 patients older than 70 years (group B) treated with arthroscopic rotator cuff repair. Patients older than 70 years were operated on only if symptoms persisted after 6 months of conservative treatment, whereas patients younger than 50 years were operated on regardless of any persistent symptoms. Imaging consisted of preoperative magnetic resonance imaging and postoperative ultrasound. Preoperative and postoperative function was evaluated with Constant and modified Constant scores. Patient satisfaction was also assessed. The evaluations were performed at least 1 year postoperatively. RESULTS No patient was lost to follow-up. The incidence of both supraspinatus and infraspinatus tears was greater in group B. Greater retraction in the frontal plane and greater fatty infiltration were observed in group B. The Constant score was significantly improved in both groups (51 ± 12.32 preoperatively v 77.18 ± 11.02 postoperatively in group A and 48.8 ± 10.97 preoperatively v 74.6 ± 12.02 postoperatively in group B, P < .05). The improvement was similar in both groups. The modified Constant score was also significantly improved in both groups (57.48 ± 18.23 preoperatively v 81.35 ± 19.75 postoperatively in group A and 63.09 ± 14.96 preoperatively v 95.62 ± 17.61 postoperatively in group B, P < .05). The improvement was greater for group B (P < .05). Partial rerupture of the rotator cuff occurred in 2 cases in group A and 5 cases in group B. Complete rerupture was observed in 2 patients in group B. In group A, 29 patients (72.5%) were very satisfied, 8 (20%) were satisfied, and 3 (7.5%) were less satisfied. In group B, 33 patients (82.5%) were very satisfied, 6 (15%) were satisfied, and only 1 (2.5%) was less satisfied. CONCLUSIONS Rotator cuff tears are characterized by greater retraction in the frontal plane and greater fatty infiltration in patients older than 70 years compared with patients younger than 50 years. After arthroscopic repair, healing is greater for patients younger than 50 years. Functional gain is at least equal between the 2 groups. LEVEL OF EVIDENCE Level IV, therapeutic case series.

Does preoperative subscapularis fatty muscle infiltration really matter in anterosuperior rotator cuff tears repair outcomes? A prospective multicentric study

INTRODUCTION Anterosuperior (AS) rotator cuff tear describes a combined tear of the subscapularis and the supraspinatus tendons. We hypothesized that results after AS tendon repairs might be influenced by the size of the subscapularis rupture and the preoperative subscapularis muscle fatty infiltration. METHODS A prospective multicentric study of 53 AS rotator cuff tears from five centers was performed (January 2008-January 2009). Subscapularis tendon retraction and fatty infiltration were assessed preoperatively. An ultrasonographic healing control was performed 1 year after surgery. RESULTS Patients were on average 60 years (range, 43-75 years) and were operated on average 16 months (range, 2-72 months) after the beginning of their symptoms. The incidence of AS tears was found to be 18%. Average follow-up was 15 months (range, 12-24). The Constant-Murley (CM) score for the patients with AS ruptures improved significantly from 49 points (range, 35-51 points) preoperatively to 73 points postoperatively (range, 50-95 points)(P=0.0205). CM score gains were 26 for Lafosse group 1 ruptures and 29 for Lafosse group 2 & 3 with pre- and postoperative P values at P<0.0000001 and P<0.000001, respectively. The last follow-up CM score according to the subscapularis fatty infiltration was 70 (range, 48-95) for groups 0-1, 70 (range, 56-87) for group 2, and 56 (range, 53-88) for groups 3-4 with pre- and postoperative P values at P<0.001, P<0.001, and P<0.004, respectively. The global retear rate was 6%. DISCUSSION Our study showed that the CM score after repairs of AS rotator cuff tears was lower in advanced subscapularis fatty infiltration. However, gains in CM scores were similar whatever the initial subscapularis fatty infiltration. The rate of tendon healing was correlated with subscapularis fatty infiltration. Subscapularis tendon rupture size was not significantly correlated with outcomes. LEVEL OF EVIDENCE Level III.