Corey O. Strickland | Researchain

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Featured researches published by Corey O. Strickland.

Bioorganic & Medicinal Chemistry Letters | 2010

The discovery of novel tartrate-based TNF-[alpha] converting enzyme (TACE) inhibitors

Kristin E. Rosner; Zhuyan Guo; Peter Orth; Gerald W. Shipps; David B. Belanger; Tin Yau Chan; Patrick J. Curran; Chaoyang Dai; Yongqi Deng; Vinay M. Girijavallabhan; Liwu Hong; Brian J. Lavey; Joe F. Lee; Dansu Li; Zhidan Liu; Janeta Popovici-Muller; Pauline C. Ting; Henry A. Vaccaro; Li Wang; Tong Wang; Wensheng Yu; Guowei Zhou; Xiaoda Niu; Jing Sun; Joseph A. Kozlowski; Daniel Lundell; Vincent Madison; Brian Mckittrick; John J. Piwinski; Neng Yang Shih

A novel series of TNF-alpha convertase (TACE) inhibitors which are non-hydroxamate have been discovered. These compounds are bis-amides of L-tartaric acid (tartrate) and coordinate to the active site zinc in a tridentate manner. They are selective for TACE over other MMPs. We report the first X-ray crystal structure for a tartrate-based TACE inhibitor.

Bioorganic & Medicinal Chemistry Letters | 2008

Potent pyrrolidine- and piperidine-based BACE-1 inhibitors.

Ulrich Iserloh; Yusheng Wu; Jared N. Cumming; J. Pan; Li Wang; Andrew Stamford; M.E. Kennedy; R. Kuvelkar; Xiao Chen; Eric M. Parker; Corey O. Strickland; Johannes H. Voigt

Bioorganic & Medicinal Chemistry Letters | 2008

Discovery of an orally efficaceous 4-phenoxypyrrolidine-based BACE-1 inhibitor

U. Iserloh; J. Pan; Andrew Stamford; M.E. Kennedy; Qi Zhang; Lili Zhang; Eric M. Parker; N.A. McHugh; Leonard Favreau; Corey O. Strickland; Johannes H. Voigt

Bioorganic & Medicinal Chemistry Letters | 2008

Rational design of novel, potent piperazinone and imidazolidinone BACE1 inhibitors

Jared N. Cumming; T.X. Le; Suresh Babu; Carolyn DiIanni Carroll; Xiao Chen; Leonard Favreau; P. Gaspari; Tao Guo; Doug W. Hobbs; Yuhua Huang; Ulrich Iserloh; M.E. Kennedy; R. Kuvelkar; Ge Li; J. Lowrie; N.A. McHugh; Lynne Ozgur; J. Pan; Eric M. Parker; Kurt W. Saionz; Andrew Stamford; Corey O. Strickland; D. Tadesse; Johannes H. Voigt; Li Wang; Yusheng Wu; Lili Zhang; Qi Zhang

Archive | 2005

Macrocyclic beta-secretase inhibitors

Andrew Stamford; Ying Huang; Guoqing Li; Corey O. Strickland; Johannes H. Voigt

Journal of Medicinal Chemistry | 2016

Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)–A β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer’s Disease

Jack D. Scott; Sarah W. Li; Andrew Brunskill; Xia Chen; Kathleen Cox; Jared N. Cumming; Eric J. Gilbert; Robert A. Hodgson; Lynn A. Hyde; Qin Jiang; Ulrich Iserloh; Irina Kazakevich; Reshma Kuvelkar; Hong Mei; John Meredith; Jeffrey Misiaszek; Peter Orth; Lana M. Rossiter; Meagan Slater; Julie A. Stone; Corey O. Strickland; Johannes H. Voigt; Ganfeng Wang; Hongwu Wang; Yusheng Wu; William J. Greenlee; Eric M. Parker; Matthew E. Kennedy; Andrew Stamford

Archive | 2010