Corey Thomas Cunningham

Immediate and extended effects of sodium lauryl sulphate exposure on stratum corneum natural moisturizing factor

Natural moisturizing factor (NMF) serves as the primary humectant of the stratum corneum (SC), principally comprised of hygroscopic amino acids and derivatives that absorb moisture. Barrier disruption has been shown to differentially affect the levels of specific NMF components, though the kinetics of NMF component restoration following disruption have not been examined. Here, we investigated the impact of barrier disruption caused by surfactant exposure on a subset of NMF components immediately following exposure and out to 10 days post‐exposure.

Immediate and extended effects of abrasion on stratum corneum natural moisturizing factor

Natural moisturizing factor (NMF), principally comprised of hygroscopic amino acids and derivatives that absorb moisture from the surrounding environment, serves as the primary humectant of the stratum corneum (SC). Acute barrier disruption has been shown to differentially affect the concentration of NMF in the SC. This study measured the recovery kinetics of NMF after mechanical damage of the SC, which is not well understood.

Impact of Stratum Corneum Damage on Natural Moisturizing Factor (NMF) in the Skin

The stratum corneum (SC) is a complex structure that protects our bodies and makes it possible for mammalian life on this planet. The SC employs a combination of both physical and biochemical processes to limit the movement of water in and out of the body although clearly it is the latter that is of most importance. The SC can be disturbed by comparatively minor injury caused by mechanical, occlusive, enzymatic, and chemical damages. Lipids and a family of hygroscopic molecules known as natural moisturizing factor (NMF) are vital to the SC’s ability to regulate epidermal permeability. This chapter reviews what is known about the impact of barrier disruption on key skin components and provides new insights into NMF responses following damage induced by sodium lauryl sulfate (SLS).