Corinne Nardin
University of Basel
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Publication
Featured researches published by Corinne Nardin.
Chemical Communications | 2000
Corinne Nardin; Sandra Thoeni; Jörg Widmer; Mathias Winterhalter; Wolfgang Meier
A new kind of nanoreactor has been prepared by the incorporation of a channel protein into the shell of (polymerized) vesicles formed from an amphiphilic ABA-triblock copolymer.
Talanta | 2001
Mathias Winterhalter; Christian Hilty; S.M Bezrukov; Corinne Nardin; Wolfgang Meier; Didier Fournier
Recent achievements of membrane protein science allow easy protein modification by genetic engineering and, for some proteins, their production in large quantities. We regard these features as the basic requirements for applications of membrane proteins in materials science. Here, we demonstrate a possible application of membrane proteins, inserting porins from the outer cell wall of Escherichia coli into the walls of liposomes. Encapsulation of enzymes into liposomes or polymer nanocapsules protects them against proteases and denaturation. Functional reconstitution of porins into the capsule shell allows to control the rate and selectivity of substrate permeation, and thus to control the enzyme reaction kinetics. We suggest that this technique can prove to be useful in the area of biosensors, providing enzymatic stability while keeping the functionality or even enhancing the sensitivity by substrate preselection. Another application of this kind of stabilisation is in the field of single enzyme activity recording.
Reviews in Molecular Biotechnology | 2002
Corinne Nardin; Wolfgang Meier
Self-assembly of reactive amphiphilic block copolymers is used to prepare nanostructured hydrogels with exceptional permeability properties, vesicular structures and planar, freestanding membranes in aqueous solution. Although the underlying block copolymer membranes are two-three-fold thicker than conventional lipid bilayers, they can be regarded as mimetic of biological membranes and can be used as a matrix for membrane-spanning proteins. Surprisingly, the proteins remain functional, despite the extreme thickness of the membranes and even after polymerization of the reactive block copolymers. The unique combination of block copolymers with membrane proteins allows the preparation of mechanically stable, defect-free membranes and nanocapsules that have highly selective permeability and/or specific recognition sites. This is documented by some representative examples.
Chemical Communications | 2001
Marc Sauer; Thomas Haefele; Alexandra Graff; Corinne Nardin; Wolfgang Meier
An ionophore assisted metal-ion transport across block copolymer membranes has been used to control the local Ca2+ concentration during precipitation of calcium phosphate in giant block copolymer vesicles.
Langmuir | 2000
Corinne Nardin; Thomas Hirt; and Jörg Leukel; Wolfgang Meier
Angewandte Chemie | 2000
Wolfgang Meier; Corinne Nardin; Mathias Winterhalter
European Physical Journal E | 2001
Corinne Nardin; J. Widmer; Mathias Winterhalter; Wolfgang Meier
Langmuir | 2000
Corinne Nardin; and Mathias Winterhalter; Wolfgang Meier
Archive | 2000
Wolfgang Meier; Thomas Hirt; Corinne Nardin
Archive | 2001
Wolfgang Meier; Corinne Nardin; Mathias Winterhalter