Cosme Furlong

Motion of the surface of the human tympanic membrane measured with stroboscopic holography

Sound-induced motion of the surface of the human tympanic membrane (TM) was studied by stroboscopic holographic interferometery, which measures the amplitude and phase of the displacement at each of about 40,000 points on the surface of the TM. Measurements were made with tonal stimuli of 0.5, 1, 4 and 8 kHz. The magnitude and phase of the sinusoidal displacement of the TM at each driven frequency were derived from the fundamental Fourier component of the raw displacement data computed from stroboscopic holograms of the TM recorded at eight stimulus phases. The correlation between the Fourier estimates and measured motion data was generally above 0.9 over the entire TM surface. We used three data presentations: (i) plots of the phasic displacements along a single chord across the surface of the TM, (ii) phasic surface maps of the displacement of the entire TM surface, and (iii) plots of the Fourier derived amplitude and phase-angle of the surface displacement along four diameter lines that define and bisect each of the four quadrants of the TM. These displays led to some common conclusions: at 0.5 and 1kHz, the entire TM moved roughly in-phase with some small phase delay apparent between local areas of maximal displacement in the posterior half of the TM. At 4 and 8 kHz, the motion of the TM became more complicated with multiple local displacement maxima arranged in rings around the manubrium. The displacements at most of these maxima were roughly in-phase, while some moved out-of-phase. Superposed on this in- and out-of-phase behavior were significant cyclic variations in-phase with location of less than 0.2 cycles or occasionally rapid half-cycle step-like changes in-phase. The high frequency displacement amplitude and phase maps discovered in this study can not be explained by any single wave motion, but are consistent with a combination of low and higher order modal motions plus some small traveling-wave-like components. The observations of the dynamics of TM surface motion from this study will help us better understand the sound-receiving function of the TM and how it couples sound to the ossicular chain and inner ear.

Computer-assisted time-averaged holograms of the motion of the surface of the mammalian tympanic membrane with sound stimuli of 0.4–25 kHz

Time-averaged holograms describing the sound-induced motion of the tympanic membrane (TM) in cadaveric preparations from three mammalian species and one live ear were measured using opto-electronic holography. This technique allows rapid measurements of the magnitude of motion of the tympanic membrane surface at frequencies as high as 25 kHz. The holograms measured in response to low and middle-frequency sound stimuli are similar to previously reported time-averaged holograms. However, at higher frequencies (f>4 kHz), our holograms reveal unique TM surface displacement patterns that consist of highly-ordered arrangements of multiple local displacement magnitude maxima, each of which is surrounded by nodal areas of low displacement magnitude. These patterns are similar to modal patterns (two-dimensional standing waves) produced by either the interaction of surface waves traveling in multiple directions or the uniform stimulation of modes of motion that are determined by the structural properties and boundary conditions of the TM. From the ratio of the displacement magnitude peaks to nodal valleys in these apparent surface waves, we estimate a Standing Wave Ratio of at least 4 that is consistent with energy reflection coefficients at the TM boundaries of at least 0.35. It is also consistent with small losses within the uniformly stimulated modal surface waves. We also estimate possible TM surface wave speeds that vary with frequency and species from 20 to 65 m/s, consistent with other estimates in the literature. The presence of standing wave or modal phenomena has previously been intuited from measurements of TM function, but is ignored in some models of tympanic membrane function. Whether these standing waves result either from the interactions of multiple surface waves that travel along the membrane, or by uniformly excited modal displacement patterns of the entire TM surface is still to be determined.

Real-time MRI-guided needle placement robot with integrated fiber optic force sensing

This paper presents the first prototype of a magnetic resonance imaging (MRI) compatible piezoelectric actuated robot integrated with a high-resolution fiber optic sensor for prostate brachytherapy with real-time in situ needle steering capability in 3T MRI. The 6-degrees-of-freedom (DOF) robot consists of a modular 3-DOF needle driver with fiducial tracking frame and a 3-DOF actuated Cartesian stage. The needle driver provides needle cannula rotation and translation (2-DOF) and stylet translation (1-DOF). The driver mimics the manual physician gesture by two point grasping. To render proprioception associated with prostate interventions, a Fabry-Perot interferometer based fiber optic strain sensor is designed to provide high-resolution axial needle insertion force measurement and is robust to large range of temperature variation. The paper explains the robot mechanism, controller design, optical modeling and opto-mechanical design of the force sensor. MRI compatibility of the robot is evaluated under 3T MRI using standard prostate imaging sequences and average signal noise ratio (SNR) loss is limited to 2% during actuator motion. A dynamic needle insertion is performed and bevel tip needle steering capability is demonstrated under continuous real-time MRI guidance, both with no visually identifiable interference during robot motion. Fiber optic sensor calibration validates the theoretical modeling with satisfactory sensing range and resolution for prostate intervention.

Wave motion on the surface of the human tympanic membrane: Holographic measurement and modeling analysis

Sound-induced motions of the surface of the tympanic membrane (TM) were measured using stroboscopic holography in cadaveric human temporal bones at frequencies between 0.2 and 18 kHz. The results are consistent with the combination of standing-wave-like modal motions and traveling-wave-like motions on the TM surface. The holographic techniques also quantified sound-induced displacements of the umbo of the malleus, as well as volume velocity of the TM. These measurements were combined with sound-pressure measurements near the TM to compute middle-ear input impedance and power reflectance at the TM. The results are generally consistent with other published data. A phenomenological model that behaved qualitatively like the data was used to quantify the relative magnitude and spatial frequencies of the modal and traveling-wave-like displacement components on the TM surface. This model suggests the modal magnitudes are generally larger than those of the putative traveling waves, and the computed wave speeds are much slower than wave speeds predicted by estimates of middle-ear delay. While the data are inconsistent with simple modal displacements of the TM, an alternate model based on the combination of modal motions in a lossy membrane can also explain these measurements without invoking traveling waves.

Optoelectronic holographic otoscope for measurement of nano-displacements in tympanic membranes

Current methodologies for characterizing tympanic membrane (TM) motion are usually limited to either average acoustic estimates (admittance or reflectance) or single-point mobility measurements, neither of which suffices to characterize the detailed mechanical response of the TM to sound. Furthermore, while acoustic and single-point measurements may aid in diagnosing some middle-ear disorders, they are not always useful. Measurements of the motion of the entire TM surface can provide more information than these other techniques and may be superior for diagnosing pathology. We present advances in our development of a new compact optoelectronic holographic otoscope (OEHO) system for full field-of-view characterization of nanometer-scale sound-induced displacements of the TM surface at video rates. The OEHO system consists of a fiber optic subsystem, a compact otoscope head, and a high-speed image processing computer with advanced software for recording and processing holographic images coupled to a computer-controlled sound-stimulation and recording system. A prototype OEHO system is in use in a medical research environment to address basic science questions regarding TM function. The prototype provides real-time observation of sound-induced TM displacement patterns over a broad frequency range. Representative time-averaged and stroboscopic holographic interferometry results in animals and human cadaver samples are shown, and their potential utility is discussed.

Absolute Shape Measurements Using High-Resolution Optoelectronic Holography Methods

Characterization of surface shape and deformation is of pri- mary importance in a number of testing and metrology applications re- lated to the functionality, performance, and integrity of components. In this paper, a unique, compact, and versatile state-of-the-art fiber-optic- based optoelectronic holography (OEH) methodology is described. This description addresses apparatus and analysis algorithms, especially de- veloped to perform measurements of both absolute surface shape and deformation. The OEH can be arranged in multiple configurations, which include the three-camera, three-illumination, and in-plane speckle corre- lation setups. With the OEH apparatus and analysis algorithms, absolute shape measurements can be made, using present setup, with a spatial resolution and accuracy of better than 30 and 10 mm, respectively, for volumes characterized by a 300-mm length. Optimizing the experimental setup and incorporating equipment, as it becomes available, having su- perior capabilities to the ones utilized in the present investigations can further increase resolution and accuracy in the measurements. The par- ticular feature of this methodology is its capability to export the measure- ments data directly into CAD environments for subsequent processing, analysis, and definition of CAD/CAE models.

Hybrid computational and experimental approach for the study and optimization of mechanical components

Increased demands on the performance and efficiency of me- chanical components impose challenges on their engineering design and optimization, especially when new and more demanding applica- tions must be developed in relatively short periods of time while satisfy- ing design objectives, as well as cost and manufacturability. In addition, reliability and durability must be taken into consideration. As a conse- quence, effective quantitative methodologies, computational and experi- mental, should be applied in the study and optimization of mechanical components. Computational investigations enable parametric studies and the determination of critical engineering design conditions, while ex- perimental investigations, especially those using optical techniques, pro- vide qualitative and quantitative information on the actual response of the structure of interest to the applied load and boundary conditions. We discuss a hybrid experimental and computational approach for investiga- tion and optimization of mechanical components. The approach is based on analytical, computational, and experimental solutions (ACES) meth- odologies in the form of computational, noninvasive optical techniques, and fringe prediction (FP) analysis tools. Practical application of the hy- brid approach is illustrated with representative examples that demon- strate the viability of the approach as an effective engineering tool for analysis and optimization.

Digital holographic measurements of shape and three-dimensional sound-induced displacements of tympanic membrane

Abstract. Acoustically induced vibrations of the tympanic membrane (TM) play a primary role in the hearing process, in that these motions are the initial mechanical response of the ear to airborne sound. Characterization of the shape and three-dimensional (3-D) displacement patterns of the TM is a crucial step to a better understanding of the complicated mechanics of sound reception by the ear. Sound-induced 3-D displacements of the TM are estimated from shape and one-dimensional displacements measured in cadaveric chinchillas using a lensless dual-wavelength digital holography system (DWDHS). The DWDHS consists of laser delivery, optical head, and computing platform subsystems. Shape measurements are performed in double-exposure mode with the use of two wavelengths of a tunable laser, while nanometer-scale displacements are measured along a single sensitivity direction with a constant wavelength. Taking into consideration the geometrical and dimensional constrains imposed by the anatomy of the TM, we combine principles of thin-shell theory together with displacement measurements along a single sensitivity vector and TM surface shape to extract the three principal components of displacement in the full-field-of-view. We test, validate, and identify limitations of this approach via the application of finite element method to artificial geometries.

A Miniature MRI-Compatible Fiber-optic Force Sensor Utilizing Fabry-Perot Interferometer

Magnetic resonance imaging provides superior imaging capability because of unmatched soft tissue contrast and inherent three-dimensional visualization. Force sensing in robot-assisted systems is crucial for providing tactile feedback and measuring tissue interaction forces in needle-based percutaneous procedures in MRI. To address the issues imposed by electromagnetic compatibility in the high-field MRI and mechanical constraints due to the confined close-bore space, this paper proposes a miniaturized fiber optic force sensor utilizing Fabry-Perot interferometry. An opto-electromechanical system is designed to experimentally validate the optical model of the sensor and evaluate its sensing capability. Calibration was performed under static and dynamics loading conditions. The experimental results indicate a gage sensitivity on the order of 40 (mV/μe) of the sensor and a sensing range of 10 Newton. This sensor achieves high-resolution needle insertion force sensing in a robust and compact configuration in MRI environment.

Motion of the tympanic membrane after cartilage tympanoplasty determined by stroboscopic holography

Stroboscopic holography was used to quantify dynamic deformations of the tympanic membrane (TM) of the entire surface of the TM before and after cartilage tympanoplasty of the posterior or posterior-superior part of the TM. Cartilage is widely used in tympanoplasties to provide mechanical stability for the TM. Three human cadaveric temporal bones were used. A 6 mm x 3 mm oval cartilage graft was placed through the widely opened facial recess onto the medial surface of the posterior or posterior-superior part of the TM. The graft was either in contact with the bony tympanic rim and manubrium or not. Graft thickness was either 0.5 or 1.0mm. Stroboscopic holography produced displacement amplitude and phase maps of the TM surface in response to stimulus sound. Sound stimuli were 0.5, 1, 4 and 7 (or 8)kHz tones. Middle-ear impedance was measured from the motion of the entire TM. Cartilage placement generally produced reductions in the motion of the TM apposed to the cartilage, especially at 4 kHz and 7 or 8 kHz. Some parts of the TM showed altered motion compared to the control in all three cases. In general, middle-ear impedance was either unchanged or increased somewhat after cartilage reconstruction both at low (0.5 and 1 kHz) and high (4 and 7 kHz) frequencies. At 4 kHz, with the 1.0mm thick graft that was in contact with the bony tympanic rim, the impedance slightly decreased. While our earlier work with time-averaged holography allowed us to observe differences in the pattern of TM motion caused by application of cartilage to the TM, stroboscopic holography is more sensitive to TM motions and allowed us to quantify the magnitude and phase of motion of each point on the TM surface. Nonetheless, our results are similar to those of our earlier work: The placement of cartilage on the medial surface of TM reduces the motion of the TM that apposes the cartilage. These obvious local changes occur even though the cartilage had little effect on the sound-induced motion of the stapes.