Costas D. Apostolopoulos

1,4‐Reductive Addition of Hydrazoic Acid to γ‐Oxo‐α,β‐unsaturated δ‐Lactones and ‐Lactams: A Convenient Route to α‐Amino‐γ‐oxo‐α,β‐unsaturated δ‐Lactones and ‐Lactams

γ-Oxo-α,β-unsaturated δ-lactones and lactams, which are easily accessible from their corresponding 2-furylcarbinols, were used as substrates for the 1,4-reductive addition of hydrazoic acid. The outcome of the reaction is the formation, in high yields, of the corresponding α-amino-γ-oxo-α,β-unsaturated δ-lactones and -lactams, compounds of great biological and synthetic interest.