Crist N. Filer

Ibotenic Acid Decarboxylation to Muscimol: Dramatic Solvent and Radiolytic Rate Acceleration

Abstract The decarboxylation of ibotenic acid to muscimol in DMSO with 3H2O or D2O is discussed.

Morphinan alkaloids labeled with tritium: synthesis and applications.

This review discusses the synthetic methods employed to tritiate morphinan alkaloids as well as their applications.

Synthesis of [Ring‐3H] Dopamine and Fluoro Analogues at High Specific Activity

Abstract Dopamine and several fluoro analogues were labeled with tritium at high specific activity by a catalytic tritium dehalogenation of polybromo precursors.

Progress in tritium NMR: 1990-2005

SummaryTritium NMR is a powerful spectroscopic technique whose understanding and applications have markedly expanded in the past few years. The growth of this area from 1990 to 2005 is reviewed.

AN IMPROVED SYNTHESIS OF 4-AMINOTETROLIC ACID

ABSTRACT An improved and efficient one pot synthesis of 4-aminotetrolic acid 1 from protected propargyl amine 2 is described.

The synthesis and characterization of [2,3-3H] gamma-aminobutyric acid via 4-aminotetrolic acid at high specific activity

Gamma-aminobutyric acid was labelled with tritium by the tritium gas catalytic reduction of a convenient 4-aminotetrolic acid derivative. The purified product was characterized by HPLC and tritium NMR.

Tritium-labelled alkaloids: Synthesis and applications: Tritium labelled alkaloids: synthesis and applications

This review discusses the synthetic methods used to tritiate nonmorphinan alkaloids as well as their applications.

Biologically active equine estrogens and sulfate conjugates labelled with tritium at high specific activity.

Methods are presented to tritiate and characterize the steroid equilin as well as a structurally related 17-alpha alcohol metabolite and several 3-position sulfate conjugates.

Trace amine receptor ligands: tritiation at high specific activity

Abstractd-amphetamine and tyramine are both amines which are active at the recently discovered trace amine-associated receptor 1 (TAAR1) and analogues of these compounds labelled with tritium would be useful reagents for neurochemistry investigators. This paper describes the tritiation and characterization of these substances. d-amphetamine was radiolabelled by a direct tritium catalytic method and characterized by proton decoupled tritium NMR. For tyramine, a bromination—catalytic tritium debromination approach worked best to afford a tritiated analogue at high specific activity.

High specific activity tritiation of several biologically active indoles

Methods are presented to synthesize and characterize [(3)H] tryptamine (1b) and [(3)H] etodolac (2c).