Cristina Dumitrescu

GH dynamics in oral glucose tolerance test in children and adolescents with tall stature

Conclusions Assessment of GH dynamics in OGTT in children and adolescents with tall stature in various stages of pubertal development for documenting a possible autonomous GH secretion. Our study included 44 subjects, 18 girls and 26 boys, aged between 6.5 years and 17.3 years diagnosed with constitutional tall stature. • The inclusion criterion was height ≥+2 DS. • The exclusion criteria were: diabetes, thyroid dysfunction, Cushings syndrome, hypothalamicpituitary pathology, renal failure, medication that alters glucose/ GH dynamics such as estrogen and thyroid hormones. • The following parameters were assesed: historical and auxological data, clinical examination, laboratory evaluations: karyotype, thyroid function, androgens, IGF1 (CLIA method with detection limit 3-1500ng/ml), IGFBP3, prolactin, evaluation of other pituitary hormone deficiency, bone age, cardiac ultrasound, eye examination, CT/MRI of the hypothalamic-pituitary region. OGTT was performed with 1.75 g/kg of glucose po. Glucose and GH (CLIA method with detection limit 0,1-80 ng/ml) were tested at 0, 30, 60, 90 and 120 minutes. • Brain imaging was performed in 20 cases. • Statistical analysis was performed using PASW software version 18, 2010 using Pearson correlation, T test, and Mann-Whitney test and the level of significance used was p 1ng/ml. • For girls GH nadir was higher than for boys. • The lowest value of GH both for girls and boys was at 90 minutes. • 2 patients with IGF1>+2DS for chronological age had normal levels of IGFBP3. • In 6 patients with GH suppression >1ng/ml, the levels of IGF1 and IGFBP3 were normal. • CT/MRI of the hypothalamic-pituitary region revealed an inhomogeneous pituitary gland. P 805