Cristina Go
University of Toronto
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Publication
Featured researches published by Cristina Go.
Epilepsia | 2011
Tomoyuki Akiyama; Bláthnaid McCoy; Cristina Go; Ayako Ochi; Irene Elliott; Mari Akiyama; Elizabeth J. Donner; Shelly K. Weiss; O. Carter Snead; James T. Rutka; James M. Drake; Hiroshi Otsubo
Purpose: High‐frequency oscillations (HFOs), termed ripples at 80–200 Hz and fast ripples (FRs) at >200/250 Hz, recorded by intracranial electroencephalography (EEG), may be a valuable surrogate marker for the localization of the epileptogenic zone. We evaluated the relationship of the resection of focal brain regions containing high‐rate interictal HFOs and the seizure‐onset zone (SOZ) determined by visual EEG analysis with the postsurgical seizure outcome, using extraoperative intracranial EEG monitoring in pediatric patients and automated HFO detection.
Clinical Neurophysiology | 2008
Hiroshi Otsubo; Ayako Ochi; Katsumi Imai; Tomoyuki Akiyama; Ayataka Fujimoto; Cristina Go; Peter Dirks; Elizabeth J. Donner
OBJECTIVE During seizures, intracranial EEG electrodes can record ictal muscle movements. Our purpose was to differentiate the high-frequency oscillations (HFOs) of extracranial muscle contractions from those of intracranial epileptogenic discharges. METHODS Using intracranial video-EEG (IVEEG), we recorded seizures in a 17-year-old boy with left mesial-temporal lobe epilepsy. We used multiple band frequency analysis (MBFA) to differentiate extracranial HFOs of craniofacial muscle activities from intracranial HFOs recorded ictally and interictally. RESULTS During 11 seizures, IVEEG showed low-amplitude fast waves ( approximately 60Hz) starting at the left mesial-temporal electrodes. Ictal facial grimacing projected low-amplitude ( approximately 20muV) fast waves ( approximately 160Hz) on inferior lateral-temporal electrodes. Interictal chewing projected medium-amplitude ( approximately 100muV) fast waves ( approximately 140Hz) correlating to mouth movements. MBFA topographic power spectrograms revealed a sustained, consistent ictal fast-frequency band from electrodes in the seizure-onset zone and randomly scattered HFOs without a specific frequency band from ictal and interictal extracranial muscle contractions. CONCLUSIONS MBFA power spectrograms differentiated randomly scattered muscle HFOs without a specific frequency band at electrodes close to temporal muscles from ictal epileptic HFOs with a sustained, fast-frequency band in the seizure-onset zone. SIGNIFICANCE The pattern and distribution of frequency power spectrograms of extracranial HFOs differ from those of intracranial HFOs.
Epilepsia | 2011
Bláthnaid McCoy; Rohit Sharma; Ayako Ochi; Cristina Go; Hiroshi Otsubo; James S. Hutchison; Eshetu G. Atenafu; Cecil D. Hahn
Purpose: Continuous electroencephalography (EEG) monitoring is a valuable tool for the detection of seizures among critically ill children, in particular when these seizures occur without clinical signs: termed nonconvulsive seizures. Continuous EEG monitoring is a limited resource in many centers. We sought to identify which critically ill children most frequently experience nonconvulsive seizures, and thus may particularly benefit from continuous EEG monitoring.
Epilepsy Research | 2008
Daniel Nilsson; Cristina Go; James T. Rutka; Bertil Rydenhag; Donald Mabbott; O. Carter Snead; Charles Raybaud; Elysa Widjaja
PURPOSE Bilateral diffusion tensor imaging (DTI) abnormalities have been reported in the white matter associated to the hippocampus in adults with mesial temporal lobe epilepsy (TLE). In children with a shorter duration of epilepsy, such changes may not have yet emerged. The aim of this study was to investigate interictal changes in the temporal lobe white matter (TLWM) and cingulate gyrus white matter (CGWM) of children with TLE using DTI. METHODS DTI was performed in eight children with TLE and 10 healthy, age-matched controls. Fractional anisotropy (FA), trace, parallel (lambda(||)) and perpendicular (lambda( perpendicular)) diffusivity were calculated for a volume of interest in the TLWM and CGWM on the seizure focus side and the contralateral side. Data were compared for differences between sides for patients and between patients and controls. RESULTS There was no significant difference in FA, trace, lambda(||) and lambda( perpendicular) between TLWM and CGWM on the seizure focus side versus the contralateral side in TLE patients. Increased diffusivity, lambda(||) and lambda( perpendicular) within the TLWM and CGWM were found in TLE patients compared to controls, but no significant difference in FA was seen. CONCLUSIONS Bilaterally increased diffusivity, lambda(||) and lambda( perpendicular) in the white matter in children with TLE may be related to seizure induced functional or structural changes. The preserved FA in our pediatric cohort is in contrast to the reduced FA in the white matter of adults with TLE and may relate to differences in the duration of epilepsy or in the vulnerability of white matter to seizures.
Epilepsia | 2014
Tohru Okanishi; Tomoyuki Akiyama; Shin Ichi Tanaka; Ellen Mayo; Ayu Mitsutake; Cyrus Boelman; Cristina Go; O. Carter Snead; James M. Drake; James T. Rutka; Ayako Ochi; Hiroshi Otsubo
Multiple tubers in patients with tuberous sclerosis complex (TSC) often are responsible for drug‐resistant epilepsy. The complexity of the epileptic network formed by multiple tubers complicates localization of the epileptogenic zone that is needed to design a surgical treatment strategy. High frequency oscillations (HFOs) on intracranial video‐electroencephalography (IVEEG) may be a valuable surrogate marker for the localization of the epileptogenic zone. The purpose of this study was to test the hypothesis that high occurrence rate (OR) of interictal HFOs can guide the localization of the epileptogenic zone.
Neurosurgical Focus | 2008
Zulma Tovar-Spinoza; Ayako Ochi; James T. Rutka; Cristina Go; Hiroshi Otsubo
Epilepsy surgery requires the precise localization of the epileptogenic zone and the anatomical localization of eloquent cortex so that these areas can be preserved during cortical resection. Magnetoencephalography (MEG) is a technique that maps interictal magnetic dipole sources onto MR imaging to produce a magnetic source image. Magneto-encephalographic spike sources can be used to localize the epileptogenic zone and be part of the workup of the patient for epilepsy surgery in conjunction with data derived from an analysis of seizure semiology, scalp video electroencephalography, PET, functional MR imaging, and neuropsychological testing. In addition, magnetoencephalographic spike sources can be linked to neuronavigation platforms for use in the neurosurgical field. Finally, paradigms have been developed so that MEG can be used to identify functional areas of the cerebral cortex including the somatosensory, motor, language, and visual evoked fields. The authors review the basic principles of MEG and the utility of MEG for presurgical planning as well as intra-operative mapping and discuss future applications of MEG technology.
Neurosurgical Focus | 2008
Cristina Go; O. Carter Snead
It is important to correctly diagnose medically intractable epilepsy in children and to identify those children whose medically refractory, localization-related seizures may be surgically remediable as soon as possible to optimize the surgical outcome. In this paper the authors review the definition of medically intractable seizures and discuss the various causes and risk factors for this disorder in children. They also outline the presurgical diagnostic evaluation process for pharmacologically intractable epilepsy in children who may be candidates for surgical treatment of localization-related seizures. The treatment of children with medically intractable epilepsy is both challenging and rewarding. Surgery has the potential of altering the natural history of epilepsy by improving or eliminating seizures in carefully selected patients.
Epilepsy Research | 2015
Elysa Widjaja; Cristina Go; Bláthnaid McCoy; O. Carter Snead
BACKGROUND The aims of this systematic review and meta-analysis were to assess (i) estimates of good neurodevelopmental outcome in infantile spasms (IS), (ii) if neurodevelopmental outcome has changed since the publication of the first guideline on medical treatment of IS in 2004 and (iii) effect of lead time to treatment (LTTT). METHODS The Medline, Embase, Cochrane, PsycINFO, Web of Science and Scopus databases, and reference lists of retrieved articles were searched. Studies inclusion criteria were: (i) >5 patients with IS, (ii) mean/median follow-up of >6 months, (iii) neurodevelopmental outcome, and (iv) randomized and observational studies. The data extracted included proportion of good neurodevelopmental outcome, year of publication, cryptogenic or symptomatic IS and LTTT. RESULTS Of the 1436 citations screened, 55 articles were included in final analysis, with a total of 2967 patients. The pooled estimate for good neurodevelopmental outcome was 0.236 (95% CI: 0.193-0.286). There was no difference between the proportions of good neurodevelopmental outcome for the 21 studies published after 2004 [0.264 (95% CI: 0.197-0.344)] compared to the 34 studies published before 2004 [0.220 (95% CI: 0.168-0.283)] (Q value=0.862, p=0.353). The pooled estimate of good neurodevelopmental outcome for cryptogenic IS [0.543 (95% CI: 0.458-0.625)] was higher than symptomatic IS [0.125 (95% CI: 0.09-0.171)] (Q value=69.724, p<0.001). Risk ratio of LTTT <4weeks relative to >4weeks for good neurodevelopmental outcome of 8 studies was 1.519 (95% CI: 1.064-2.169). CONCLUSION Neurodevelopmental outcome was overall poor in patients with IS and has not changed since the publication of first guideline on IS. Although cryptogenic IS has better prognosis than symptomatic IS, the outcome for cryptogenic IS remained poor. There was heterogeneity in neurodevelopmental outcome ascertainment methods, highlighting the need for a more standardized and comprehensive assessment of cognitive, behavioural, emotional and functional outcomes.
Epilepsia | 2011
Sorawit Viravan; Cristina Go; Ayako Ochi; Tomoyuki Akiyama; O. Carter Snead; Hiroshi Otsubo
Purpose: Jeavons syndrome (JS) is one of the underreported epileptic syndromes characterized by eyelid myoclonia (EM), eye closure–induced seizures/electroencephalography (EEG) paroxysms, and photosensitivity. JS has been proposed as idiopathic generalized epilepsy (IGE) because of normal posterior dominant background activity and paroxysmal generalized ictal epileptiform discharges (EDs). However, we noticed subtle occipital EDs preceding EM and interictal posterior EDs using digital video‐EEG. We studied clinical and EEG findings in JS to determine the specific occipital lobe relation to this “eye closure–induced” reflex IGE.
Epilepsia | 2013
Elysa Widjaja; Jovanka Skocic; Cristina Go; O. Carter Snead; Donald Mabbott; Mary Lou Smith
The white matter (WM) is considered critical for linking cortical processing networks necessary for cognition. The aim of this study was to assess diffusion tensor imaging (DTI) measures of regional WM in children with nonlesional localization‐related epilepsy in comparison to controls, and to determine the relation between lobar WM and neuropsychological performance.