Cristina Rodríguez-García

REPIGMENTATION OF VITILIGO LESIONS IN A CHILD WITH CELIAC DISEASE AFTER A GLUTEN-FREE DIET

Abstract:  There is a well‐established association of vitiligo with autoimmune conditions, and circulating autoantibodies to melanocytes have been demonstrated in the serum of patients with vitiligo. We present a case of repigmentation of vitiligo lesions in a girl with celiac disease after initiating a gluten‐free diet, which to our knowledge has not been reported.

Successful Response to Topical Tacrolimus for a Granuloma Faciale in an Elderly Patient

plaques, papules or nodules over the dorsa of joints, and GF usually appears as one or a few plaques on the face. In addition, eosinophils and plasma cells are prominent in GF, whereas neutrophils are plentiful in erythema elevatum diutinum [1] . GF is often quite resistant to therapy [2–6] . Topical calcineurin inhibitors may represent a useful alternative to topical corticosteroids for the treatment of a number of other inflammatory skin diseases different from atopic dermatitis [7] . We report a 90-year-old male patient without remarkable medical history who presented to our department with an asymptomatic lesion on the nasal tip. This lesion had been present for 6 months, and gradual enlargement had been observed. Physical examination revealed an oval, well-delimited, reddish yellow plaque, 2.5 ! 1.5 cm in size, with a smooth and brilliant surface. Focal telangiectasia and follicular openings were also found ( fig. 1 ). A biopsy specimen was obtained which showed a dense dermal polymorphous inflammatory infiltrate with neutrophils, lymphocytes, plasma cells and numerous eosinophils. A narrow grenz zone and a mild fibrosis area were also found. With these histological findings, a diagnosis of GF was made. Therapy with topical 0.1% tacrolimus ointment twice daily was started after he had not responded to the application of topical corticosteroids. Treatment was stopped after 3 months with remission lasting for 1 year. Only slight reddish coloration at the edges of the lesion remained ( fig. 2 ). No burning sensation was noted.

Prevalence of Cutaneous Findings in Spanish Neonates and Relationships to Obstetric and Parental Factors

Abstract:  Two hundred forty‐seven healthy newborns were investigated in a prospective cohort descriptive study. Information on phenotype and obstetric and parental history was collected. A positive association was found between erythema toxicum neonatorum and season of birth (spring and summer), whereas parental history of any skin disease was related to a lower frequency of this eruption.

Lesión cutánea de rápido crecimiento en hombro derecho

Paciente mujer de 75 años que acudió a consulta por una lesión a sintomática en el hombro derecho, de 5 meses de evolución. Entre sus antecedentes personales figuraban: hidronefrosis izquierda y bronquiectasias pulmonares. En la exploración fı́sica se observaba una lesión tumoral nodular, ulcerada, fluctuante, de aproximadamente 5 cm de diámetro, en el hombro derecho (figs. 1 y 2). En el estudio histopatológico con hematoxilina-eosina destacaba la presencia de granulomas no caseificantes en la dermis (fig. 3); con la tinción de ZiehlNeelsen no se mostraron bacilos ácido-alcohol resistentes. El cultivo de la muestra fue negativo para bacterias, hongos y micobacterias, pero, a través de la prueba de reacción en cadena de la polimerasa, se detectó ADN de Mycobacterium tuberculosis, llegándose al diagnóstico de tuberculosis cutánea gomosa.

Rapidly growing cutaneous lesion in the left shoulder

Paciente mujer de 75 años que acudió a consulta por una lesión a sintomática en el hombro derecho, de 5 meses de evolución. Entre sus antecedentes personales figuraban: hidronefrosis izquierda y bronquiectasias pulmonares. En la exploración fı́sica se observaba una lesión tumoral nodular, ulcerada, fluctuante, de aproximadamente 5 cm de diámetro, en el hombro derecho (figs. 1 y 2). En el estudio histopatológico con hematoxilina-eosina destacaba la presencia de granulomas no caseificantes en la dermis (fig. 3); con la tinción de ZiehlNeelsen no se mostraron bacilos ácido-alcohol resistentes. El cultivo de la muestra fue negativo para bacterias, hongos y micobacterias, pero, a través de la prueba de reacción en cadena de la polimerasa, se detectó ADN de Mycobacterium tuberculosis, llegándose al diagnóstico de tuberculosis cutánea gomosa.