Csaba P. Kovesdy
University of California, Los Angeles
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Publication
Featured researches published by Csaba P. Kovesdy.
Diagnostics | 2018
Zhongji Han; Zhousheng Xiao; Kamyar Kalantar-Zadeh; Hamid Moradi; Tariq Shafi; Sushrut Waikar; Leigh Darryl Quarles; Zhi Yu; Adrienne Tin; Josef Coresh; Csaba P. Kovesdy
End stage renal disease (ESRD) is characterized by complex metabolic abnormalities, yet the clinical relevance of specific biomarkers remains unclear. The development of multiplex diagnostic platforms is creating opportunities to develop novel diagnostic and therapeutic approaches. SOMAscan is an innovative multiplex proteomic platform which can measure >1300 proteins. In the present study, we performed SOMAscan analysis of plasma samples and validated the measurements by comparison with selected biomarkers. We compared concentrations of SOMAscan-measured prostate specific antigen (PSA) between males and females, and validated SOMAscan concentrations of fibroblast growth factor 23 (FGF23), FGF receptor 1 (FGFR1), and FGFR4 using Enzyme-Linked immunosorbent assay (ELISA). The median (25th and 75th percentile) SOMAscan PSA level in males and females was 4304.7 (1815.4 to 7259.5) and 547.8 (521.8 to 993.4) relative fluorescence units (p = 0.002), respectively, suggesting biological plausibility. Pearson correlation between SOMAscan and ELISA was high for FGF23 (R = 0.95, p < 0.001) and FGFR4 (R = 0.69, p < 0.001), indicating significant positive correlation, while a weak correlation was found for FGFR1 (R = 0.13, p = 0.16). In conclusion, there is a good to near-perfect correlation between SOMAscan and standard immunoassays for FGF23 and FGFR4, but not for FGFR1. This technology may be useful to simultaneously measure a large number of plasma proteins in ESRD, and identify clinically important prognostic markers to predict outcomes.
Archive | 2016
Kamyar Kalantar-Zadeh; Linda W. Moore; Amanda R. Tortorici; Jason A. Chou; David E. St-Jules; Arianna Aoun; Vanessa Rojas-Bautista; Annelle Tschida; Connie M. Rhee; Anuja Shah; Susan T. Crowley; Joseph A. Vassalotti; Csaba P. Kovesdy
Archive | 2016
Vanessa Ravel; Seyed-Foad Ahmadi; Elani Streja; Jonathan Sosnov; Csaba P. Kovesdy; Kamyar Kalantar-Zadeh; Joline L.T. Chen
Archive | 2015
Connie M. Rhee; Danh V. Nguyen; Hamid Moradi; Steven M. Brunelli; Ramanath Dukkipati; Jennie Jing; Tracy Nakata; Csaba P. Kovesdy; Gregory A. Brent; Kamyar Kalantar-Zadeh
Archive | 2015
Morgan E. Grams; Yingying Sang; Josef Coresh; Shoshana H. Ballew; Kunihiro Matsushita; Miklos Z Molnar; Zoltán Szabó; Kamyar Kalantar-Zadeh; Csaba P. Kovesdy
Archive | 2015
Lin Li; Elani Streja; Connie M. Rhee; Rajnish Mehrotra; Melissa Soohoo; Steven M. Brunelli; Csaba P. Kovesdy; Kamyar Kalantar-Zadeh
Archive | 2014
Tania Vashistha; Rajnish Mehrotra; Jongha Park; Elani Streja; Ramnath Dukkipati; Allen R. Nissenson; Jennie Z. Ma; Csaba P. Kovesdy; Kamyar Kalantar-Zadeh
Archive | 2013
Parta Hatamizadeh; Miklos Z Molnar; Elani Streja; Paungpaga Lertdumrongluk; Mahesh Krishnan; Csaba P. Kovesdy; Kamyar Kalantar-Zadeh
Archive | 2012
Paungpaga Lertdumrongluk; Csaba P. Kovesdy; Keith C. Norris; Kamyar Kalantar-Zadeh
Archive | 2012
Csaba P. Kovesdy; Kamyar Kalantar-Zadeh; David Geff