Csaba Varga

Some Applications to Variational—Hemivariational Inequalities of the Principle of Symmetric Criticality for Motreanu---Panagiotopoulos Type Functionals

Using the principle of symmetric criticality for Motreanu–Panagiotopoulos type functionals we give some existence and multiplicity results for a class of variational–hemivariational inequalities on

On the proper study design applicable to experimental balneology.

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Historical public health in central Europe with special reference to Hungary. Long-term environmental effects of a historical cataclysm

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Mesothelioma and Environmental Exposure

First of all, thanks the International Journal of Biometeo-rology for giving us an opportunity to discuss thenomenclature problems of a science with 1,000-year-oldtraditions (Gutenbrunner et al. 2010). Secondly, I wouldlike to express my gratitude to the authors for their hugeand hard work. The task is urgently required; the lack ofexact definitions and keywords profoundly inhibits prepa-ration of systematic reviews and meta-analyses. An obviousconsequence would be the conservation of this medicalfield at a stage that is far from the level of evidence-basedmedicine. I can agree with the authors in vast majority oftheir proposals; however, allow me also to call attention tosome basic non-medical aspects of this issue.BalneologyMy first question is very simple and basic. Should wedefine the word Balneology at all? “Health ResortMedicine, Balneology, Medical Hydrology and Climatol-ogy are not fully recognised as independent medicalspecialities” write the authors in the first sentence. In myopinion, Balneology should be deleted from this listbecause it is not a medical field or speciality. It is muchmore: a basic science. As a basic science, it involvesapproaches, methodologies (in brief: knowledge) fromhydrology, geology, geochemistry, analytical chemistry,microbiology, ecology, etc., and of course medicine aswell. This means that geology or chemistry may alsodefine this terminus technicus based upon their specificapproaches. I do not think we have the right to define itusing our specific attitudes, which reflect only a slice ofthis big pie. We would rather use (and of course define)Medical Balneology

Localization method for the solutions of nonhomogeneous operator equations

The simple message of this paper is that it is the high time to reevaluate the strategies and optimize the efforts for investigation of thermal (spa) waters. Several articles trying to clear mode of action of medicinal waters have been published up to now. Almost all studies apply the unproven hypothesis, namely the inorganic ingredients are in close connection with healing effects of bathing. Change of paradigm would be highly necessary in this field taking into consideration the presence of several biologically active organic substances in these waters. A successful design for experimental mechanistic studies is approved.

Betegforgalmi trendek multidiszciplináris sürgősségi osztályon

Despite the lack of knowledge of their exact effects, peloids (natural muds) are widely applied in clinical treatment and prevention of different diseases, especially in rheumatic and gynecological disorders or skin diseases. Primarily we have information on their inorganic components, but only limited data are available on the organic components and nothing on their mechanism of chemical action. The objective of the present study was to detect the DNA-damaging effects (possible genotoxic effect) of peloid samples using the single-cell comet assay on Long Evans rat lymphocytes, human lymphocytes, and Eisenia fetida coelomocytes. Rat and human lymphocytes were exposed to the in toto peloid samples, in vitro. The Eisenia cells were extracted from the coelom of animals kept in the intact peloid sample. An indicator derived from the DNA fluorescence intensity was used in the statistical evaluation. The predominantly organic (Hévíz) sample showed a significant alteration from the negative control in several cases, while the inorganic (Kolop) applied did not. A higher quantity of organic compounds may have an important role in the emergence of DNA damage. The results revealed that medical muds have not only positive health effects but can also contain substances with potential human toxicity risk. Our research provides essential steps towards the creation of a toxicity profile and the possible safe use of peloids as medicinal therapy.

Multi-endpoint biological monitoring in combined, carcinogenic occupational exposures

Hungary, in the centre of Carpathian basin grapples with numerous challenges in order to improve catastrophic indices of environmental conditions of the country, as well as the state of health of the population. Some of these problems are subjects of financial and health policy, and can be solved internally. The remaining environmental problems can only be remedied by cooperation with neighbouring younger countries. This vitally important cooperation is hampered by severe historical conflicts burdening even the present political affiliations. The authors give a short introduction and explanation of the recent sensitive situation in this central European region, as a late consequence of an historical cataclysm happened more than nine decades ago.

Lack of Genotoxicity of Carbon Nanotubes in a Pilot Study

A novel animal model was developed to study the direct exposure of mesothelial cells to crocidolite and chrysotile asbestos fibers. Chemically pure and pretreated Union Internationale Centre le Cancer (UICC) samples were implanted into a peritoneal envelope (Kertais fold) of Wistar rats. Following the 12‐month exposure, lack of mesothelioma induction was detected in all groups. Results suggest that the mechanism of mesothelioma formation is not a consequence of peritoneal physical exposure to the fibers.