Cy Lau

Bleeding-related hospital admissions and 30-day re-admissiona with dabigatran versus warfarin in patients with non-valvular atrial fibrillation

PHASE 2 OPEN-LABEL EXTENSION (OLE) STUDY OF PATISIRAN, AN INVESTIGATIONAL RNA INTERFERENCE (RNAI) THERAPEUTIC FOR THE TREATMENT OF HEREDITARY ATTR AMYLOIDOSIS WITH POLYNEUROPATHYOBJECTIVES Maturity onset diabetes of the young (MODY) is a genetic form of diabetes for which 13 genes are known to be responsible. Many subtypes of MODY can be treated with oral medication instead of insulin injections, which results in improved metabolic control, quality of life and cost savings. Massively parallel sequencing (MPS) enables the simultaneous sequencing of all 13 genes for a fraction of the cost of traditional Sanger sequencing. We conducted a cost utility analysis of genetic screening (targeted MPS) for MODY in a paediatric population presumed to have type 1 diabetes (T1D), where the underlying prevalence of MODY has been calculated as 2.6%. METHODS A Markov decision model was developed to estimate the incremental costs and quality-adjusted life years (QALYs) of genetic screening for MODY compared with standard care over 50 years’ follow up. The probabilities and quality of life weightings (utility) of long term diabetic complications were estimated from published data and population statistics. Costs were estimated from the perspective of the Australian health care system. RESULTS Genetic screening for MODY at diabetes diagnosis was more effective and less costly than standard care, with 1.39 QALYs gained and AU

Effectiveness of gastroprotective agents on prevention of dabigatran related gastrointestinal bleeding: a population-based restrospective cohort study

1.4 million (US

The unmet needs of antithrombotic treatment in patients with non-valvular atrial fibrillation in real-world clinical practice

1.05 million) saved per 1,000 patients. The costs of the screening program were fully offset within four years. A sensitivity analysis revealed that genetic screening remained dominant until the MODY prevalence fell below 0.7%. CONCLUSIONS Screening for MODY in the paediatric diabetes population would reduce health system costs and improve patient quality of life. Our results were robust to assumptions around the underlying MODY prevalence and make a compelling argument for routine genetic screening in all children with presumed T1D.Poster Presentations Session IV - CCardiovascular Disorders - Clinical Outcomes Studies - no. PCV27OBJECTIVES: Traditionally, researchers relied on eliciting preferences through face-to-face interviews. Recently, there has been a shift towards using alternative modes, such as the internet, to gather such data. These different modes may be a source of variation in the results. In health services research, preferences are important as they provide an estimate of the value of each quality of life state, and can be used as weights to reflect the differential utility of each state. In this study, we compare the preferences elicited from two modes of administration (internet versus face-to-face) for the best-worst scaling (BWS) technique using the Adult Social Care Outcomes Toolkit service user measure (ASCOT-S). METHODS: Data were collected from a representative sample of the general population in England. The respondents (face-to-face: n=500; online: n=1,001) completed a survey which included the BWS experiment involving the ASCOT-S, consisted of 32 tasks which were blocked into 4 segments. Multinomial logistic regressions were undertaken to analyse the data. To allow for direct comparisons between the modes, model coefficients were standardised. RESULTS: Respondents in the face-to-face survey placed lower value on the lower levels of all ASCOT-S domains, except social participation, than those in the internet survey. The highest point difference of 0.12 was observed in Level 2 of the occupation domain. For the highest level of all ASCOT-S domains, except social participation, preference weights were higher in the face-to-face survey than the internet with point differences of up to 0.10. CONCLUSIONS: This study compared utility weights obtained from a BWS exercise using two modes of administration for the ASCOTS. The findings showed variation of responses between the two modes. Most differences were not significant and were low in absolute value. This suggests that preference weights are similar across the different modes of administration. We reflect on the implications of these findings for cost-effectiveness research.

Hospitalization and length of stay among patients with non-valvular atrial fibrillation taking dabigatran or warfarin: a population-based cohort study

12th ISoPAnnual Meeting ‘New Landscapes for Pharmacovigilance’ Cancun, Mexico 30 October–2 November 2012 ABSTRACTS Drug Saf 2012; 35 (10): 877-970 0114-5916/12/0010-0877/

Dabigatran versus warfarin in patients with non-valvular atrial fibrillation: a population-wide cohort study in Chinese patients

49.95/0 Adis a 2012 Springer International Publishing AG. All rights reserved.

Suboptimal management of patients with Non-Valvular Atrial Fibrillation: Real-World Clinical setting

12th ISoPAnnual Meeting ‘New Landscapes for Pharmacovigilance’ Cancun, Mexico 30 October–2 November 2012 ABSTRACTS Drug Saf 2012; 35 (10): 877-970 0114-5916/12/0010-0877/

Persistence of Dabigatran Versus Warfarin Therapy in Patients with Non-Valvular Atrial Fibrillation in the Real-World Clinical Practice

49.95/0 Adis a 2012 Springer International Publishing AG. All rights reserved.