Cyle S. Goodman

Systemic CD56+ Cells Can Predict Pregnancy Outcome

PROBLEM: To evaluate differences in circulating CD56+ cells between successful and unsuccessful pregnancies, 114 pregnant women were studied prospectively.

Which thrombophilic gene mutations are risk factors for recurrent pregnancy loss

Problem  Thrombophilia has been associated with poor obstetrical outcomes. To determine the association of specific inherited thrombophilias and recurrent pregnancy loss, 10 thrombophilic genes were investigated.

The association of Apoprotein E polymorphisms with recurrent pregnancy loss.

Problem  We have previously reported the role of polymorphisms of thrombogenic genes involved in coagulation and fibrinolysis as risk factors for recurrent pregnancy loss. Thrombophilia has been viewed as a multigenic disorder rather than a monogenetic clinical phenotype and Apo E has been shown to play an important role in lipid metabolism in pregnancy. As individuals carrying the E4 allele of the ApoE gene have the highest risk for thrombosis, we evaluated the frequency of the Apo E4 genotype among women suffering from recurrent pregnancy loss.

Are polymorphisms in the ACE and PAI-1 genes associated with recurrent spontaneous miscarriages?

Problem  To determine whether the ACE D/D genotype or the combination of PAI‐1 4G/4G and ACE D/D genotypes may serve as a risk factor for recurrent pregnancy loss.

ORIGINAL ARTICLE: The Association of Apoprotien E Polymorphisms with Recurrent Pregnancy Loss

Problem  We have previously reported the role of polymorphisms of thrombogenic genes involved in coagulation and fibrinolysis as risk factors for recurrent pregnancy loss. Thrombophilia has been viewed as a multigenic disorder rather than a monogenetic clinical phenotype and Apo E has been shown to play an important role in lipid metabolism in pregnancy. As individuals carrying the E4 allele of the ApoE gene have the highest risk for thrombosis, we evaluated the frequency of the Apo E4 genotype among women suffering from recurrent pregnancy loss.

ORIGINAL ARTICLE: Are Polymorphisms in the ACE and PAI-1 Genes Associated with Recurrent Spontaneous Miscarriages?

Problem  To determine whether the ACE D/D genotype or the combination of PAI‐1 4G/4G and ACE D/D genotypes may serve as a risk factor for recurrent pregnancy loss.

ORIGINAL ARTICLE: The Association of Apoprotien E Polymorphisms with Recurrent Pregnancy Loss: APO E AND RPL

Problem  We have previously reported the role of polymorphisms of thrombogenic genes involved in coagulation and fibrinolysis as risk factors for recurrent pregnancy loss. Thrombophilia has been viewed as a multigenic disorder rather than a monogenetic clinical phenotype and Apo E has been shown to play an important role in lipid metabolism in pregnancy. As individuals carrying the E4 allele of the ApoE gene have the highest risk for thrombosis, we evaluated the frequency of the Apo E4 genotype among women suffering from recurrent pregnancy loss.

Assisted Reproductive Technologies and Immune Infertility

The fields of reproduction and immunology are now interfacing to enhance the ability of women to achieve their desired family size. Much work needs to be done to understand the role of immunologic processes in both fertilization, implantation, and maintenance of a healthy pregnancy.

ORIGINAL ARTICLE: Are Polymorphisms in the ACE and PAI-1 Genes Associated with Recurrent Spontaneous Miscarriages?: POLYMORPHISMS IN THE ACE AND PAI-1 GENES

Problem  To determine whether the ACE D/D genotype or the combination of PAI‐1 4G/4G and ACE D/D genotypes may serve as a risk factor for recurrent pregnancy loss.

1139687336 Which thrombophilic gene mutations are risk factors for recurrent pregnancy loss

Objective:  We have previously reported that when 10 thrombophilic genes were investigated, more than three gene mutations among the 10 genes were observed significantly more frequently among women experiencing recurrent pregnancy loss than fertile control women. The question then arose as to which of the 10 mutations were necessary to identify the risk of recurrent pregnancy loss. The present study was undertaken to answer this question.