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Cynthia L. Sundell

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Publication

Featured researches published by Cynthia L. Sundell.

Bioorganic & Medicinal Chemistry Letters | 2002

Novel Phenolic Antioxidants as Multifunctional Inhibitors of Inducible VCAM-1 Expression for Use in Atherosclerosis

Charles Q. Meng; Patricia K. Somers; Carolyn L. Rachita; Lisa A. Holt; Lee K. Hoong; X.Sharon Zheng; Jacob E. Simpson; Russell R. Hill; Lynda K. Olliff; Charles Kunsch; Cynthia L. Sundell; Sampath Parthasarathy; Uday Saxena; James A. Sikorski; Martin A. Wasserman

A series of novel phenolic compounds has been discovered as potent inhibitors of TNF-alpha-inducible expression of vascular cell adhesion molecule-1 (VCAM-1) with concurrent antioxidant and lipid-modulating properties. Optimization of these multifunctional agents led to the identification of 3a (AGI-1067) as a clinical candidate with demonstrated efficacies in animal models of atherosclerosis and hyperlipidemia.

Journal of Pharmacology and Experimental Therapeutics | 2003

AGI-1067: A Multifunctional Phenolic Antioxidant, Lipid Modulator, Anti-Inflammatory and Antiatherosclerotic Agent

Cynthia L. Sundell; Patricia K. Somers; Charles Q. Meng; Lee K. Hoong; Ki-Ling Suen; Russell R. Hill; Laura K. Landers; Angela Chapman; Dustie Butteiger; Moira Jones; David G. Edwards; Alan Daugherty; Martin A. Wasserman; R. Wayne Alexander; Russell M. Medford; Uday Saxena

American Journal of Cardiology | 2003

Chemistry and pharmacology of vascular protectants: a novel approach to the treatment of atherosclerosis and coronary artery disease

Martin A. Wasserman; Cynthia L. Sundell; Charles Kunsch; David G. Edwards; Charles Q. Meng; Russell M. Medford

Journal of Medicinal Chemistry | 2007

Carboxylated, heteroaryl-substituted chalcones as inhibitors of vascular cell adhesion molecule-1 expression for use in chronic inflammatory diseases.

Charles Q. Meng; Liming Ni; Kimberly J. Worsencroft; Zhihong Ye; M. David Weingarten; Jacob E. Simpson; Jason W. Skudlarek; Elaine M. Marino; Ki-Ling Suen; Charles Kunsch; Amy Souder; Randy B. Howard; Cynthia L. Sundell; Martin A. Wasserman; James A. Sikorski

Archive | 2002

Methods to increase plasma HDL cholesterol levels and improve HDL functionality with probucol monoesters

Jayraz Luchoomun; Cynthia L. Sundell; Uday Saxena; James A. Sikorski

Journal of Medicinal Chemistry | 2004

Discovery of novel phenolic antioxidants as inhibitors of vascular cell adhesion molecule-1 expression for use in chronic inflammatory diseases.

Charles Q. Meng; Patricia K. Somers; Lee K. Hoong; X.Sharon Zheng; Zhihong Ye; Kimberly J. Worsencroft; Jacob E. Simpson; Martha R. Hotema; M. David Weingarten; Mathew L. MacDonald; Russell R. Hill; Elaine M. Marino; Ki-Ling Suen; Jayraz Luchoomun; Charles Kunsch; Laura K. Landers; Dimitria Stefanopoulos; Randy B. Howard; Cynthia L. Sundell; Uday Saxena; Martin A. Wasserman; James A. Sikorski

Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents | 2005

Oxidative Stress and the Use of Antioxidants for the Treatment of Rheumatoid Arthritis

Charles Kunsch; James A. Sikorski; Cynthia L. Sundell

Archive | 2002

PROBUCOL MONOESTERS AND THEIR USE TO INCREASE PLASMA HDL CHOLESTEROL LEVELS AND IMPROVE HDL FUNCTIONALITY

Jayraz Luchoomun; Uday Saxena; Cynthia L. Sundell; James A. Sikorski

Journal of Pharmacology and Experimental Therapeutics | 2005

AGIX-4207 [2-[4-[[1-[[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]-1-methylethyl]thio]-2,6-bis(1,1-dimethylethyl)phenoxy]acetic Acid], a Novel Antioxidant and Anti-Inflammatory Compound: Cellular and Biochemical Characterization of Antioxidant Activity and Inhibition of Redox-Sensitive Inflammatory Gene Expression

Charles Kunsch; Jayraz Luchoomun; Xi-Lin Chen; Geraldine Dodd; Kanika S. Karu; Charles Q. Meng; Elaine M. Marino; Lyn K. Olliff; J. Daniel Piper; Fei-Hua Qiu; James A. Sikorski; Patricia K. Somers; Ki-Ling Suen; Suzanne Thomas; Anne M. Whalen; Martin A. Wasserman; Cynthia L. Sundell

Transplantation | 2004

Effects of AGI-1096, A novel antioxidant compound with anti-inflammatory and antiproliferative properties, on rodent allograft arteriosclerosis

Seiichiro Murata; Cynthia L. Sundell; Maarten A. Lijkwan; Leora B. Balsam; Pekka Hämmäinen; Caroline T. Coleman; Chris York; Jayraz Luchoomun; Ki-Ling Suen; Randy Howard; Patricia K. Somers; Randall E. Morris; Robert C. Robbins

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James A. Sikorski

Monsanto

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Charles Kunsch

Scripps Research Institute

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Martin A. Wasserman

Baylor College of Medicine

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David G. Edwards

University of Delaware

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Randy B. Howard

Emory University

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Russell M. Medford

Emory University

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Alan Daugherty

University of Kentucky

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Dustie Butteiger

Pfizer

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Jason W. Skudlarek

United States Military Academy

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Leora B. Balsam

Stanford University

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