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D A Matthews

University of California, San Diego

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Publication

Featured researches published by D A Matthews.

Journal of Biological Chemistry | 1982

Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. I. General features and binding of methotrexate.

Jeffrey T. Bolin; David J. Filman; D A Matthews; R.C Hamlin; Joseph Kraut

Science | 1977

Dihydrofolate reductase: x-ray structure of the binary complex with methotrexate.

D A Matthews; Ra Alden; Jeffrey T. Bolin; St Freer; R.C Hamlin; N Xuong; Joseph Kraut; M Poe; M Williams; K Hoogsteen

Journal of Biological Chemistry | 1985

Refined crystal structures of Escherichia coli and chicken liver dihydrofolate reductase containing bound trimethoprim.

D A Matthews; Jeffrey T. Bolin; J M Burridge; David J. Filman; K W Volz; Kaufman Bt; Christopher Raymond Beddell; John N. Champness; David K. Stammers; Joseph Kraut

Journal of Biological Chemistry | 1978

Dihydrofolate reductase from Lactobacillus casei. X-ray structure of the enzyme methotrexate.NADPH complex.

D A Matthews; Alden Ra; Jeffrey T. Bolin; David J. Filman; Freer St; Hamlin R; Hol Wg; Roy L. Kisliuk; Edward J. Pastore; Laurence T. Plante; Xuong N; Joseph Kraut

Journal of Biological Chemistry | 1982

Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. II. Environment of bound NADPH and implications for catalysis.

David J. Filman; Jeffrey T. Bolin; D A Matthews; Joseph Kraut

Journal of Biological Chemistry | 1982

Crystal structure of avian dihydrofolate reductase containing phenyltriazine and NADPH.

K W Volz; D A Matthews; Richard A. Alden; S T Freer; Corwin Hansch; Kaufman Bt; Joseph Kraut

Journal of Biological Chemistry | 1975

X-ray crystallographic study of boronic acid adducts with subtilisin BPN' (Novo). A model for the catalytic transition state.

D A Matthews; Richard A. Alden; J J Birktoft; S T Freer; Joseph Kraut

Journal of Biological Chemistry | 1985

Dihydrofolate reductase. The stereochemistry of inhibitor selectivity.

D A Matthews; Jeffrey T. Bolin; J M Burridge; David J. Filman; K W Volz; Joseph Kraut

Journal of Biological Chemistry | 1977

Re-examination of the charge relay system in subtilisin comparison with other serine proteases.

D A Matthews; Richard A. Alden; J J Birktoft; Freer T; Joseph Kraut

Journal of Biological Chemistry | 1979

Dihydrofolate reductase from Lactobacillus casei. Stereochemistry of NADPH binding.

D A Matthews; Richard A. Alden; S T Freer; Nguyen-Huu Xuong; Joseph Kraut

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Collaboration

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Joseph Kraut

University of California

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Jeffrey T. Bolin

Purdue University

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David J. Filman

Harvard University

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Richard A. Alden

University of California

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S T Freer

University of California

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J M Burridge

University of California

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Christopher Raymond Beddell

Research Triangle Park

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Corwin Hansch

Pomona College

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Edward J. Pastore

Tufts Medical Center

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Laurence T. Plante

Tufts University

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