D Bendayan
Rabin Medical Center
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Publication
Featured researches published by D Bendayan.
Respiration | 2008
D Bendayan; R. Sarid; A. Cohen; David Shitrit; I. Shechtman; Mordechai R. Kramer
Background:Pulmonary hypertension is a severe pulmonary vascular disease leading to rapid deterioration and death. Histological and clinical evidence suggests that smooth muscle proliferation is part of the pathogenesis of the disease. Human herpesvirus 8 (HHV-8) is a γ-herpesvirus that is implicated in malignancies and in Kaposi’s sarcoma. Recently, the association of HHV-8 with idiopathic pulmonary arterial hypertension (PAH) has been found. Objective: The aim of this study was to investigate the presence of HHV-8 in the lung tissue of Israeli patients with PAH. Method: The presence of HHV-8 sequences was investigated by polymerase chain reaction examination in 6 biopsies of patients with pulmonary hypertension. Three patients had idiopathic pulmonary hypertension, 2 patients pulmonary venoocclusive disease, and 1 patient pulmonary hypertension associated with mixed connective tissue disease. Result: We did not find any association between HHV-8 and PAH in these Israeli patients, as all the samples were negative for polymerase chain reaction. Conclusion: Our findings, together with the epidemiological data of HHV-8 prevalence and incidence rates of Kaposi’s sarcoma and PAH in Israel, provide further evidence which argues against an association between HHV-8 infection and PAH.
Respiration | 2002
David Shitrit; D Bendayan; B. Rudensky; Gabriel Izbicki; Michael Huerta; Gershon Fink; Mordechai R. Kramer
Background: Vasoconstriction, vascular wall remodeling and thrombosis are considered as possible etiologies of primary pulmonary hypertension (PPH). D-dimer, a degradation product of fibrin, has been increasingly used as a marker and prognostic factor in various diseases. Objective: To assess elevated ELISA D-dimer levels as a marker of endogenous fibrinolysis in patients with PPH. Patients and Methods: Comparison of ELISA D-dimer levels of 12 PPH patients (11 female, 1 male) aged 27–73 years (median 51 years) with those of sex- and age-matched healthy controls. Results: Eleven patients had New York Heart Association (NYHA) class III or IV symptoms, and one patient had NYHA class II symptoms. All patients with PPH were treated with anticoagulants and vasodilators: 5 patients were treated with continuous intravenous prostacyclin, 4 patients with continuous UT-15 and 2 patients with intermittent intravenous iloprost. Mean ELISA D-dimer levels ± SD were significantly higher in the PPH group than in the matched control group (473 ± 109 vs. 182 ± 103 ng/ml; mean difference: 291 ± 79, 95% CI: 240–341, p < 0.0001). Conclusion: These results suggest the possible involvement of endogenous fibrinolysis in the pathophysiology of PPH.
Transplantation Proceedings | 2003
Daniel Starobin; Gershon Fink; David Shitrit; Gabriel Izbicki; D Bendayan; Ilana Bakal; Mordechai R. Kramer
ULMONARY INFECTIOUS complications are common in patients after solid organ transplantation (SOT) or bone marrow transplantation (BMT) and are responsible for significant morbidity and mortality. Early diagnosis of infectious complications is extremely important for the outcome of transplant recipients 1‐3 The purpose of this study was to examine the role of fiberoptic bronchoscopy (FOB) in transplant recipients with suspected pulmonary infections. METHODS The study was conducted at the Institute of Pulmonary Medicine. Rabin Medical Center, Beilinson Campus (a tertiary-care university hospital). We retrospectively examined data of patients posttransplantation who required FOB from May 5, 1999 until May 2002. Indications for FOB were suspected pulmonary infection by either abnormal chest X-ray or respiratory symptoms. Lung transplant recipients with surveillance bronchoscopies were excluded from the study. Patients underwent bronchoalveolar lavage (BAL); specimens were analyzed as bacteriology, virology, fungal, and mycobacterial cultures. In 65% of cases, transbronchial biopsies (TBBs) were done; specimens were sent to pathological examination as well as silver and cytomegalovirus (CMV)-specific stains.
Respiratory Medicine | 2000
D Bendayan; Y. Barziv; Mordechai R. Kramer
Chest | 2006
Gabriel Izbicki; David Shitrit; Alex Yarmolovsky; D Bendayan; Galit Miller; Gershon Fink; Asher Mazar; Mordechai R. Kramer
Respiratory Medicine | 2003
D Bendayan; David Shitrit; M Ygla; Michael Huerta; Gershon Fink; Mordechai R. Kramer
Respiratory Medicine | 2009
Gabriel Izbicki; Itsik Ben-Dor; David Shitrit; D Bendayan; Thomas K. Aldrich; Ran Kornowski; Mordechai R. Kramer
Journal of Heart and Lung Transplantation | 2005
Gabriel Izbicki; David Shitrit; Itzhak Schechtman; D Bendayan; Gershon Fink; Gideon Sahar; Milton Saute; Tuvia Ben-Gal; Mordechai R. Kramer
Thorax | 2004
David Shitrit; D Bendayan; Milton Saute; Mordechai R. Kramer
Thorax | 2007
Ben Fox; I. Shechtman; David Shitrit; D Bendayan; Mordechai R. Kramer