D. de Vos

Some aspects of the gas—liquid chromatographic analysis of cyclophosphamide in plasma

Abstract The gas—liquid chromatography of cyclophosphamide has been extensively investigated. Several methods for the assay of cyclophosphamide in plasma are reported, those with the nitrogen—phosphorus-specific detection being most sensitive and selective.

Aromatic lead(IV) compounds : X. H and C NMR spectroscopy of compounds ArnPb(OAc)4−n (n 14)

Abstract 1 H and 13 C NMR data are reported for the compounds Ar n Pb(OAc) 4− n ( n  14). The increase of the 207 Pb 1 H and 207 Pb 13 C coupling constants with the number of acetate groups is explained in terms of changes in hybridization and effective nuclear charge. The occurrence of solvent effects is discussed for C 6 H 5 Pb(OAc) 3 . The effects of the solvent depend primarily on the dielectric constant and the coordinating properties. In methanol, methanolysis may occur.

Assay of HA-966 in rat plasma by capillary gas-liquid chromatography with nitrogen-selective detection.

A gas-liquid chromatographic method for the determination of the gamma-aminobutyric acid-like drug 1-hydroxy-3-aminopyrrolidone-2 (HA-966) in plasma is described. HA-966 was converted into its diacetyl derivative AC2HA-966 with acetic anhydride. This compound could be suitable eluted from a capillary OV-17 support-coated open tubular column. A sensitive detection method was achieved by making use of nitrogen-phosphorus-selective flame ionization.