D. K. Daftary
Tata Institute of Fundamental Research
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Cancer | 1969
Fali S. Mehta; J. J. Pindborg; Prakash C. Gupta; D. K. Daftary
The paper presents the results of an epidemiologic house‐to‐house survey of oral cancer and lcukoplakia among 50,915 adult villagers in 4 states of India which were selected according to various types of chewing and smoking habits. Twenty‐six oral cancer cases were found in the survey. The prevalence of leukoplakia ranged from 0.2 to 4.9%. There was a predominance of men. Leukoplakias were already observed in the 15‐ to 24‐year age group, and a considerable number were in the 25‐ to 34‐year age group. Intra‐oral locations of the leukoplakias were found to vary within the 4 states depending upon the chewing and smoking habits prevailing. The leukoplakias were analyzed with regard to intra‐oral locatios and correlation with habits. Special habits like hookli smoking and reverse smoking are associated with leukoplakias on the labial mucosa and on the palate, respectively. The histologic analysis of biopsies from 723 leukoplakias showed variations in the type of hyperkeratosis which may depend upon habits. The prevalence of epithelial atypia ranged from 3.0% to 12.4% in the 4 states. Epithelial atypia was seen in 8.4% of homogeneous leukoplakias but in 59.1% of speckled leukoplakias.
Cancer | 1989
Prakash C. Gupta; R. B. Bhonsle; P. R. Murti; D. K. Daftary; Fali S. Mehta; J. J. Pindborg
A cohort of 12,212 tobacco users was followed up annually to assess malignant potential of oral precancerous lesions in the Ernakulam district in Kerala, India. A total of 19 new oral cancers were diagnosed over a period of 8 years, and 15 (79%) of these arose from some preexisting precancerous lesion or condition. Nodular leukoplakia showed highest rate of malignant transformation (16% per year) as six of 13 nodular leukoplakia underwent malignant transformation over a mean follow‐up period of 2.8 years. The relative risk (3243.2) compared with individuals with tobacco habits but without any precancerous oral lesion was also the highest for nodular leukoplakia. In addition, nodular leukoplakia was associated with submucous fibrosis in two patients, which progressed to oral cancer and was the clinical diagnosis for four lesions that turned out to be malignant on histopathologic examination. Nodular appearance was noted in two other precursor lesions as well. Thus, 14 of 19 oral cancers (74%) were either preceded by nodular leukoplakia and with lesions showing a distinct nodular appearance, or had the clinical appearance of nodular leukoplakia.
Oral Surgery, Oral Medicine, Oral Pathology | 1977
J. J. Pindborg; D. K. Daftary; Fali S. Mehta
In a 7-year follow-up study of 107 cases of oral epithelial dysplastic precancerous lesions in Indian villagers, 6.6 per cent were found to develop into carcinomas. A clinical spontaneous regression occurred in 14.8 per cent. Follow-up biopsies showed histologic regression of dysplasia in six cases.
The Lancet | 1986
Prakash C. Gupta; JensJ. Pindborg; R. B. Bhonsle; P. R. Murti; FaliS. Mehta; Mira Aghi; D. K. Daftary; H.T. Shah; P. N. Sinor
In a house-to-house survey, 36 471 tobacco chewers and smokers were selected from the rural population in three areas of India. These individuals were interviewed for their tobacco habits and examined for the presence of oral leukoplakia and other precancerous lesions, first in a baseline survey, and then annually over a 5-year period. By personal advice and via the mass media they were encouraged to give up their tobacco habits. The follow-up rate was 97%. The control cohort was provided by the first 5-year results from a 10-year follow-up study conducted earlier in the same areas with the same methodology but on different individuals without any educational intervention. In Ernakulam district (Kerala) and Srikakulam district (Andhra) substantially more people stopped their tobacco habit and reduced the frequency of tobacco use in the intervention cohort than in the control cohort; in Bhavnagar district (Gujarat) the intervention group showed only a slightly higher proportion stopping their tobacco habits and no difference in the proportion reducing them. The 5-year age-adjusted incidence rate of leukoplakia in Ernakulam district was 11.4 in the intervention group versus 47.8 among men, and 5.8 versus 33.0 among women; and for palatal lesions in Srikakulam district the corresponding figures were 59.8 versus 260.8 among men and 289.5 versus 489.5 among women. In Bhavnagar the incidence rate of leukoplakia did not differ between the cohorts. Since most oral cancers are preceded by precancerous lesions, education on tobacco habits should be a feasible and effective approach to primary prevention of oral cancer.
Oral Surgery, Oral Medicine, Oral Pathology | 1972
Fali S. Mehta; B.C. Shroff; Prakash C. Gupta; D. K. Daftary
Abstract This is a report of a second follow-up study of 3,674 Bombay policemen after 10 years. One among 117 patients with leukoplakia was reported to have developed oral cancer in the 10-year period. The 10-year incidence rate for leukoplakia was 2.8 per cent. Among chewers, the leukoplakia regressed, whereas among smokers, the leukoplakia was found to be more persistent. Although tobacco chewing remained the most prevalent form of tobacco habit, cigarette smoking was found to be on the increase.
Oral Surgery, Oral Medicine, Oral Pathology | 1980
J. J. Pindborg; R. B. Bhonsle; P. R. Murti; Prakash C. Gupta; D. K. Daftary; Fali S. Mehta
The yearly incidence of submucous fibrosis per 100,000 person-years was found to be 9 for males and 20 for females over a 10-year period in the Ernakulam district of Kerala, South India. In the same area possible early case of submucous fibrosis, under the clinical diagnosis of leukoplakia and lichen planus, showed the typical histologic features of the disease.
International Journal of Oral Surgery | 1977
Fali S. Mehta; P. N. Jalnawalla; D. K. Daftary; Prakash C. Gupta; J. J. Pindborg
In Srikakulam, India, 101 patients with palatal lesions due to reverse smoking were followed for 1 year at monthly intervals to analyze the behavior of the various components of their palatal lesions. Of these patients, 24% stopped the habit completely and 27% changed to the conventional type of smoking. Palatal keratosis was very stable, whereas red areas changed into nonpigmented areas. Epithelial dysplasia was found in 23% of the 101 biopsies, the highest being in the red areas. Mild inflammation was seen in about half of the biopsies.
Oral Surgery, Oral Medicine, Oral Pathology | 1969
Fali S. Mehta; D. K. Daftary; B.C. Shroff; L.D. Sanghvi
Abstract 1. 1. The criteria used for clinical and histopathologic changes in leukoplakia are given in detail. 2. 2. This is a 5-year follow-up study of 3,785 men out of an initial group of 4,734 who were examined in 1959. 3. 3. A detailed clinicopathologic correlation is presented. 4. 4. A correlation of the clinical appearance of the lesions with the habits indulged in is presented. 5. 5. No malignant transformation of leukoplakia lesion was reported after a 5-year follow-up study, and no lesions diagnosed as clinical leukoplakia were found to be carcinoma in situ. 6. 6. Of 161 leukoplakia cases, twenty cases were histologically diagnosed as atypias. 7. 7. The homogeneous type of leukoplakia accounted for only 3.7 per cent of the atypias, while the speckled accounted for 8.6 per cent. 8. 8. Bidi smoking, pan chewing, and mixed habits are significantly responsible for leukoplakias, in the descending order of importance.
Journal of Dental Research | 1971
James E. Hamner; Fali S. Mehta; J. J. Pindborg; D. K. Daftary
Fifty-four oral biopsies were performed on 53 submucous fibrosis patients among 50,915 rural villagers in the Indian states of Kerala, Gujarat, Bihar, and Andhra Pradesh. Histologic sections revealed a definite alteration in the tinctorial quality of the connective tissues when stained by the Rinehart and van Gieson methods. The connective tissues in submucous fibrosis patients tended to be amorphous and nonbundular, in contrast to that seen in the normal controls.
British Journal of Cancer | 1972
Fali S. Mehta; B. E. Sahiar; D. K. Daftary; Prakash C. Gupta; J. J. Pindborg
A correlative histocytological study was made of 6 patients with palatal carcinomata and 342 patients with palatal lesions (primarily leukoplakias) associated with reverse smoking from the Srikakulam district of Andhra Pradesh. Among 6 histologically diagnosed carcinomata only 2 showed cytological findings typical of carcinoma. Of the 46 atypias diagnosed histologically among the other palatal lesions, only 6 (13%) were diagnosed cytologically. Our findings show that cytological examination of precancerous and cancerous lesions located on the hard palate, which is a highly keratinized area of the oral cavity, may not be reliable enough for revealing premalignant or malignant changes.