D. Kolbah

CHIRAL 1,4‐BENZODIAZEPINES PART 5, SYNTHESIS AND PROPERTIES OF 1,4‐BENZODIAZEPIN‐2‐ONES CONTAINING ALPHA‐AMINO ACIDS AS A PART OF THE 1,4‐DIAZEPINE RING

Chiral 1,4-benzodiazepin-2-ones XIII-XXIIII (Scheme 1) were prepared starting from N-protected α-amino acids and 2-amino-5chlorobenzeophenone; the intermediates I-XII were isolated and identified. Spectroscopie propertiec of these componds are discussed (ir, nmr); their optical stability, as well as the cyclization rate for XII-XIII in buffer solution have been determined.

Testosterone, epitestosterone and androstenedione in the pollen of scotch pineP. silvestris L.

Im Pollen vonPinus silvestris L. wurden die androgenen Steroide Testosteron, epi-Testosteron und 4-Androsten-3,7-dion nach vier verschiedenen Methoden bestimmt.

Sex hormones and corticosteroids in pollen of Pinus nigra

Abstract In continuation of earlier investigations on steroid hormones in the pollen of pine, we have isolated and quantitatively determined the following steroids by radioimmunoassay and fluorimetric methods: testosterone, testosterone together with epitestosterone, respectively, and androstenedione; progesterone was determined by radioimmunoassay alone. In addition, we have tried to isolate cortisol, cortisone, 11-deoxycortisol, corticosterone and 11 -deoxycorticosterone and to characterize these compounds by specific reactions. The intensity of these reactions were used to estimate the amounts of corticosteroids in pollen.

Chiral aminoacid containing macrocycles

Abstract Optically active macrocycles (R, R)- 8 - 10 and diastereomeric mixtures of (±)- 8 - 10 and meso-(R, S)- 8 - 10 were prepared containing two (R)- or (S)-α-phenylglycine units as sources of chirality.

CHIRAL AMINOACID CONTAINING MACROCYCLES

Das Phenylglycinderivat (I) reagiert mit den Diolen (II) auf bekanntem Wege zu den Estern (V).

SYNTHESIS AND DESULFURATION OF THIANAPHTHEN-3-CARBOXYLIC ACID DERIVATIVES

Abstract Recently, we have been interested in the synthesis of some heterocyclic compounds as potential antiinflammatoric agents1. Derivatives of thianaphthen-3-carboxylic acid might also show such activity. Therefore, a rational synthetic pathway for these compounds was developed: