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D Kowlessur

St Bartholomew's Hospital

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Publication

Featured researches published by D Kowlessur.

Biochemical Journal | 1988

Supracrystallographic resolution of interactions contributing to enzyme catalysis by use of natural structural variants and reactivity-probe kinetics.

Keith Brocklehurst; S M Brocklehurst; D Kowlessur; M O'Driscoll; G Patel; E Salih; W Templeton; Emrys W. Thomas; C M Topham; F Willenbrock

Biochemical Journal | 1987

Substrate-derived two-protonic-state electrophiles as sensitive kinetic specificity probes for cysteine proteinases. Activation of 2-pyridyl disulphides by hydrogen-bonding.

Keith Brocklehurst; D Kowlessur; M O'Driscoll; G Patel; S Quenby; E Salih; W Templeton; E W Thomas; F Willenbrock

Biochemical Society Transactions | 1990

Isolation and characterization of gingivain, a cysteine proteinase from Porphyromonas gingivalis strain W83

Haroun N. Shah; Saheer E. Gharbia; D Kowlessur; Elizabeth Wilkie; Keith Brocklehurst

Biochemical Journal | 1989

Identification of signalling and non-signalling binding contributions to enzyme reactivity. Alternative combinations of binding interactions provide for change in transition-state geometry in reactions of papain.

D Kowlessur; C M Topham; Emrys W. Thomas; M O'Driscoll; W Templeton; Keith Brocklehurst

Biochemical Journal | 1989

The interplay of electrostatic fields and binding interactions determining catalytic-site reactivity in actinidin: a possible origin of differences in the behaviour of actinidin and papain

D Kowlessur; M O'Driscoll; C M Topham; W Templeton; Emrys W. Thomas; Keith Brocklehurst

Biochemical Journal | 1988

Consequences of molecular recognition in the S1-S2 intersubsite region of papain for catalytic-site chemistry. Change in pH-dependence characteristics and generation of an inverse solvent kinetic isotope effect by introduction of a P1-P2 amide bond into a two-protonic-state reactivity probe.

Keith Brocklehurst; D Kowlessur; G Patel; W Templeton; K Quigley; Emrys W. Thomas; Christopher W. Wharton; F Willenbrock; Ronald J. Szawelski

Biochemical Journal | 1990

Dependence of the P2-S2 stereochemical selectivity of papain on the nature of the catalytic-site chemistry. Quantification of selectivity in the catalysed hydrolysis of the enantiomeric N-acetylphenylalanylglycine 4-nitroanilides

D Kowlessur; Emrys W. Thomas; C M Topham; W Templeton; Keith Brocklehurst

Biochemical Journal | 1989

The interplay of electrostatic and binding interactions determining active centre chemistry and catalytic activity in actinidin and papain.

Keith Brocklehurst; M O'Driscoll; D Kowlessur; I R Phillips; W Templeton; Emrys W. Thomas; Christopher M. Topham; Christopher W. Wharton

Biochemical Journal | 1990

A re-appraisal of the structural basis of stereochemical recognition in papain. Insensitivity of binding-site-catalytic-site signalling to P2-chirality in a time-dependent inhibition.

W Templeton; D Kowlessur; Emrys W. Thomas; C M Topham; Keith Brocklehurst

Biochemical Society Transactions | 1990

Studies on streptococcal proteinase

Hayley French; Ralph Williams; E Salih; D Kowlessur; Keith Brocklehurst

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Collaboration

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Keith Brocklehurst

St Bartholomew's Hospital

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W Templeton

St Bartholomew's Hospital

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Emrys W. Thomas

University of Salford

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C M Topham

St Bartholomew's Hospital

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M O'Driscoll

St Bartholomew's Hospital

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G Patel

St Bartholomew's Hospital

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E Salih

St Bartholomew's Hospital

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F Willenbrock

St Bartholomew's Hospital

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Christopher M. Topham

Centre national de la recherche scientifique

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Christopher W. Wharton

University of Birmingham

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