D. Maitraie

MICROWAVE ASSISTED KNOEVENAGEL CONDENSATION: A FACILE METHOD FOR THE SYNTHESIS OF CHALCONES *

Microwave irradiation of aromatic aldehydes with acetophenones or malonic acid in presence of anhydrous zinc chloride was resulted exclusively chalcones and cinnamic acids respectively in high yields. *IICT Communication No: 4643.

Design, synthesis, structure-activity relationship and antibacterial activity series of novel imidazo fused quinolone carboxamides.

A series of novel 7,8 and 1,8 imidazo fused quinolone carboxamides are synthesized and evaluated against antibacterial activity. 1,8 Imidazo fused quinolones exhibit moderate antibacterial activity. Molecular modeling studies were carried out to optimize the pharmacophore.

Synthesis of Novel 5‐Trifluoromethyl‐2,4,7‐Trisubstituted Pyrido[2,3‐d]Pyrimidines

Abstract Novel pyrido[2,3‐d]pyrimidines (2,4) were synthesized by reacting 2‐amino‐3‐cyano‐4‐trifluoromethyl‐6‐substituted pyridines (1) with Grignard reagent followed by condensation with anhydride/chloroacetylchloride/aromatic aldehyde. aIICT Communication No.: 040104.

A simple and facile method for the synthesis of novel 5/7 trifluoromethyl-substituted 4(3H)-quinazolone regioisomers

Abstract The unsymmetrical 1,3-diketones 1 on reaction with malononitrile is resulted an interesting trifunctional intermediates 2 and 3 . The intermediate 2 is hydrolyzed to give 2,6-dicarboxamido aniline 4 which on cyclisation gave two regioisomers of 1,2-dihydro-4(3H)-quinazolinones 5 and 6 . The effect of substituents on compound 4 is characteristic for formation of regioisomers in different proportions. Each regioisomer on dehydrogenation under mild condition using active MnO 2 gave corresponding 4(3H)-quinazolones 7 and 8 , respectively.

Microwave Assisted Intramolecular Wittig Reaction: A Facile Method for the Synthesis of Conjugated Acetylenes

Abstract A rapid and efficient synthesis of acetylenic compounds by the microwave assisted intramolecular Wittig reaction of β-oxo-alkylidene-triphenylphosphoranes is reported. #IICT Communication No. 020106.

A SIMPLE AND CONVENIENT METHOD FOR THE REDUCTION OF NITROARENES

ABSTRACT A variety of nitroarenes such as simple, electron rich and electron poor were reduced on Al2O3 support in presence of sodium hydrogen sulphide under microwave condition to give the corresponding aromatic amines in high yields. It is found that the substituents at different positions on nitrobenzene have no influence except 2d on the rate of reaction and yields of product. IICT Communication No: 4843