Publication


Featured researches published by D. Meester.


Transplantation | 2003

Functional and structural integrity of porcine pancreatic grafts subjected to a period of warm ischemia and cold preservation with histidine-tryptophan-ketoglutarate (Custodiol) or University of Wisconsin solution

Roberto Troisi; D. Meester; Carolien Van Den Broecke; Claude Cuvelier; Tom Fiers; Bernard de Hemptinne; Uwe Hesse

Background. University of Wisconsin (UW) solution (Viaspan) is currently used to preserve organs from nonheartbeating donors. Histidine-tryptophan-ketoglutarate (HTK) solution (Custodiol) is of proven efficacy in experimental pancreas preservation, but its efficacy in combined warm ischemia (WI) and cold ischemia (CI) is unknown. The viability of HTK-preserved porcine pancreatic grafts was assessed after various periods of WI and compared with grafts flushed and preserved with UW solution. Methods. A total of 14 pigs were used: G1 (n=4, UW) and G2 (n=4, HTK) with 15-min WI and 16-hr cold storage; G3 (n=3, UW) and G4 (n=3, HTK) with 30-min WI and 16-hr cold storage. Results. All animals in G1 and G2 were normoglycemic, whereas only 66% of pancreases were functioning in G3 and G4. HTK perfusion was associated with increased wet weight. Transient hyperinsulinemia was noted in all the groups on postoperative day 1 (mean range: 8.9–12.4 &mgr;U/L). Postoperative serum amylase and lipase were more pronounced in G3 and G4. However, HTK-stored grafts exhibited less evidence of biochemical pancreatitis as compared with UW-stored grafts on the first postoperative day in the group with 15-min WI. Mean K values of intravenous glucose tolerance tests on postoperative day 14 were similar in both groups. Vascular congestion was uniformly observed and was considered a typical feature of WI. Conclusions. Porcine pancreatic grafts are viable after 16-hr CI following 15-min WI in this experimental nonheartbeating donor model. HTK solution seems to provide reliable graft function in this setting and to be equivalent to UW.


Transplant International | 2000

Physiologic and metabolic results of pancreatic cold storage with Histidine-Tryptophan-Ketoglutarate-HTK solution (Custodiol) in the porcine autotransplantation model.

Rebecca Troisi; D. Meester; B. Regaert; B Jacobs; C. Van den Broucke; Claude Cuvelier; B. de Hemptinne; Uwe Hesse


Transplantation Proceedings | 2002

Tolerance of the porcine pancreas to warm and cold ischemia: comparison between University of Wisconsin and histidine–tryptophan–ketoglutarate solution

Roberto Troisi; D. Meester; B. Regaert; C Van Den Broecke; Claude Cuvelier; Uwe Hesse


Journal of Hepatology | 2010

131 HEPATIC STELLATE CELL ACTIVATION: AN IMPORTANT CONTRIBUTOR TO PERSISTENT HEPATIC RESISTANCE IN SMALL-FOR-SIZE LIVERS AFTER EXTENDED PARTIAL HEPATECTOMY IN THE RAT

Ye-Dong Fan; Eline Vanheule; D. Meester; J. Van Huysse; Kim Olievier; M. Praet; Isabelle Colle; B. de Hemptinne


Journal of Hepatology | 2008

511 INCREASED SHEAR STRESS ALONE CAN INDUCE HEPATIC PROLIFERATION IN NORMAL LIVERS

Ye-Dong Fan; Cuiying Chen; D. Meester; J. Van Huysse; Sylviane Dewaele; Valerie Vanhooren; Claude Libert; M. Praet; F. Roels; B. de Hemptinne


Journal of Hepatology | 2008

531 THE ROLE OF PLACENTAL GROWTH FACTOR AND ITS RECEPTOR IN LIVER REGENERATION AFTER PARTIAL HEPATECTOMY

Eline Vanheule; Ye-Dong Fan; J. Van Huysse; D. Meester; M. Praet; B. de Hemptinne; Isabelle Colle


Hepatology | 2008

Intravital fluorescence microscopy study of the intrahepatic microcirculation during liver regeneration in different partial hepatectomy rat models

Eline Vanheule; Ye-Dong Fan; Jacques Van Huysse; D. Meester; Marleen Praet; Bernard de Hemptinne; Isabelle Colle


Gastroenterology | 2008

M1898 The Role of Vascular Endothelial Growth Factor and Its Receptor in Liver Regeneration After Partial Hepatectomy

Eline Vanheule; Ye-Dong Fan; Jacques Van Huysse; D. Meester; Marleen Praet; Bernard de Hemptinne; Isabelle Colle


Gastroenterology | 2008

M1899 The Role of Placental Growth Factor and Its Receptor in Liver Regeneration After Partial Hepatectomy

Eline Vanheule; Ye-Dong Fan; Jacques Van Huysse; D. Meester; Marleen Praet; Bernard de Hemptinne; Isabelle Colle


Journal of Hepatology | 2006

119 Controlled increase of portal inflow induces hepatic hyperplasia without major liver damage

Ye-Dong Fan; D. Meester; J. Van Huysse; M. Praet; F. Roels; G. De Boeck; L. Urbanavicius; Rebecca Troisi; B. de Hemptinne

Researchain Logo
Decentralizing Knowledge