D. Thienpont

Miconazole, a Broad-Spectrum Antimycotic Agent with Antibacterial Activity

Miconazole tested in vitro against the most important fungi pathogenic for man and animals, and against gram-positive bacteria has proved to be highly potent. The dermatophytes, yea

Ketoconazole -- a new broad spectrum orally active antimycotic.

Oral treatment with ketoconazole prevented and cured artificial crop candidosis of the turkey, vaginal candidosis of the rat and skin candidosis of the guinea-pig. It was also highly effective against artificial systemic candidosis of the guinea-pig and chicken as well as against dermatophytoses of the guinea-pig.

Systemic antifungal potential, safety, biotransport and transformation of micronazole nitrate

SummaryMiconazole nitrate was investigated in 169 normal volunteers for its safety and its antifungal action on the bronchial and intestinal flora after oral administration, and for its biotransport and transformation after oral, intravaginal and percutaneous administration. — Oral doses of 3 g a day for nine weeks produced no haematological, biochemical or ECG abnormalities. Within the first week of treatment, miconazole significantly reduced the number of fungal colonies in cultures of sputum and faeces, and inhibited tetracycline-induced fungal overgrowth in the faeces. Oral miconazole significantly improved dermatophytosis. — Miconazole was absorbed moderately well from the gastrointestinal tract and was virtually not absorbed from the mucous membrane and skin.

Vapour Phase Activity of Imazalil

A series of in vitro experiments with imazalil is described. It is demonstrated that the compound has fungistatic, fungicidal and even sporocidal activity in the vapour phase against a wide variety of fungal species, e.g., dermatophytes, Candida albicans, and plant-pathogenic fungi. Possible practical applications are discussed.

Experimental cutaneous Candida albicans infection in guinea-pigs.

A characteristic infection pattern was observed in nonscarified adult guinea-pigs that had been artificially infected with Candida albicans, and injected with 1 dose of 200 mg/kg of alloxan. Lesions appeared less rapidly in nonscarified animals but within 8–15 days of the induced infection the lesions were maximal and were much more homogeneous than in scarified animals. The guinea-pig is an excellent laboratory model for the study of anticandidal substances.