Dae-Kyoo Chung

A Clinical Report of a Psychosomatic patient who has treated by Giungoroen-therapy based on Song Psychotherapy

Objectives : This study was performed to report the effect of Giungoroen-therapy based on song psychotherapy in the treatment resistant patient with psychosomatic disease. Methods : A 43 year-old female patient suffered from headache, facial numbness, right upper and lower limb`s numbness, ptosis, chest discomfort, dysarthria without identifiable physical cause. We diagnosed her as psychosomatic disease, and tried to apply Giungoroen-therapy with Korean traditional medical treatment. But she was resistant to Giungoroen-therapy. So we applied Giungoroen-therapy based on song psychotherapy. Results : After the Giungoroen-therapy based on song psychotherapy, the patient revealed her unrecognized hidden issues and got some insights about herself. Then the symptoms, such as headache, facial numbness, right upper and lower limb`s numbness, ptosis, chest discomfort and dysarthria were reduced considerably. Conclusions : These results suggest that Giungoroen-therapy based on song psychotherapy can be effective on improvement of resistant psychosomatic disease.

Nootropic and Anti-amnestic Effect of PPA on scopolamine-induced Cognitive Impairment in Mice

In the present study, we assessed the effect of the PPA (Polygala japonica Houtt., Polygala tenuifolia WILLD. and Acorus gramineus SOLAND. mixed preparation), a traditional herbal prescription, on the learning and memory impairments induced by scopolamine. The cognition-enhancing effect of PPA was investigated using a passive avoidance test, Y-maze test and the Morris water maze test in mice. Drug-induced amnesia was induced by treating animals with scopolamine (1 mg/kg, i.p.). A single PPA (400 and 800 (mg/kg)) administration significantly reversed the scopolamine-induced cognitive impairments in the passive avoidance test (P

Studies on the Behavioral Pharmacology of the Antidepressant Effect of Polygala japonica Houtt

Objectives : The purpose of this study was to characterize the putative antidepressant and antianxiolytic effects of the 70% ethanol extract of Polygala japonica(EEPJ) using animal`s behavioral experiment in mice. Methods : The effect of EEPJ on the anxioty and depressive disorder was investigated via mice`s behavioral experiment like Elevated plus-maze, Horizontal wire test, Open field test, Forced swimming test, Tail suspension test, and it was happen via any mechanism by WAY 100635, a 5-HT1A receptor antagonist and by Flumazenil, a GABAA antagonist Results : 1. In the EPM, single treatments of the EEPJ(200 and 400mg/kg) had usefully antianxiolytic effects versus vehicle, which was medicated via the serotonergic nervous system. 2. In the HWT, single treatments of the EEPJ were no changes in the myorelaxant effects versus vehicle. 3. In the OFT, single treatments of the EEPJ were no changes in the locomotor activity versus vehicle. 4. In the FST, single treatments of the EEPJ(50mg/kg) significantly reduced the immobility time versus vehicle. 5. In the TST, single treatments of the EEPJ(50mg/kg) significantly reduced the immobility time versus vehicle. Conclusions : These results indicate that EEPJ is an effective antidepressant and antianxiolytic activity in mice, and it might be usefully applied for prevention and treatment of depressive disorder through evolutive study like development of various experimental models.

Studies on the Nootropic and Anti-amnestic and Anxiolytic-like Effects of G.J.D-P.P.A. in Mice

Objectives : The purpose of this study was to characterize the neuroprotective effects and anxiolytic-like effects of Gongjin-dan and Polygala japonica, Polygala tenuifolia, Acorus gramineus mixed pills(G.J.D-P.P.A.). Methods : The neuroprotective effects of G.J.D-P.P.A. determined by the passive avoidance and Y-maze tasks and Morris water maze task, and the anxiolytic-like effects of the G.J.D-P.P.A. using an elevated plus-maze(EPM) in mice. Results : Drug-induced amnesia was induced by treating animals with scopolamine(1 mg/kg, i.p.). A single G.J.D-P.P.A.(400 and 800 mg/kg) administration significantly enhanced cognitive function and attenuated scopolamine-induced cognitive impairments as determined by the passive avoidance and Y-maze tasks(P