Daisuke Horii

Self-Supported Methoxylation and Acetoxylation Electrosynthesis Using a Simple Thin-Layer Flow Cell

Self-supported electrochemical methoxylation and acetoxylation of various organic molecules were carried out using a thin-layer flow cell without intentionally added supporting electrolyte. The thin-layer flow cell employed in this work had a simple geometry with working and auxiliary electrodes directly facing each other with 80 mu m distance. Controlling factors for these kinds of self-supported electrochemical methoxylation and acetoxylation, such as the electrode material, the current density, and the flow rate were optimized to allow moderate to high yields of the corresponding methoxylated and acetoxylated products to be achieved in single flow-through operations. (c) 2006 The Electrochemical Society.

A novel electrosynthetic system for anodic substitution reactions by using parallel laminar flow in a microflow reactor.

We have developed a novel electrosynthetic system for anodic substitution reactions by using parallel laminar flow in a microflow reactor. This system enables nucleophilic reactions to overcome the restraint, such as the oxidation potential of nucleophiles and the stability of cationic intermediates, by the combined use of ionic liquids as reaction media and the parallel laminar flow in the microflow reactor. By using this novel electrosynthetic system, the anodic substitution reaction of carbamates, especially of cyclic carbamates, with allyltrimethylsilane were carried out to provide the corresponding products in moderate to good conversion yields in a single flow-through operation at ambient temperature (without the need for low-temperature conditions).

Self-supported paired electrosynthesis using a microflow reactor without intentionally added electrolyte

We have developed a paired electrosynthetic system using a microflow reactor. This system enables paired electrochemical reactions composed of chloride reduction/alcohol oxidation combination to progress without intentionally added electrolyte. In addition, the use of parallel laminar flow in the microflow reactor resulted in a further improvement of the desired product yields in the paired electrosynthesis.