Daisuke Inagaki

Relation of MT1‐MMP gene expression to outcomes in colorectal cancer

Matrix metalloproteinases are members of a large family of endopeptidases that participate in the extracellular‐matrix degradation that accompanies cancer cell invasion, metastasis and angiogenesis. The membrane‐type 1 matrix metalloproteinase (MT1‐MMP) gene has been reported in various cancers and is associated with tumor invasion and metastasis. This study examined the relation of the relative expression of MT1‐MMP gene to clinicopathological factors and outcomes in patients with colorectal cancer (CRC).

Massive portal vein tumor thrombus from colorectal cancer without any metastatic nodules in the liver parenchyma

Metastatic lesions in the liver derived from colorectal cancer rarely invade the portal vein macroscopically. Portal vein tumor thrombus is commonly associated with hepatocellular carcinoma. Colorectal liver metastases are usually accompanied by microscopic tumor invasion into the intrahepatic portal vein, and the incidence of macroscopic tumor thrombus in the trunk of the portal vein is rare. Here, we provide unique appearance of metastatic colorectal cancer. To the best of our knowledge, macroscopically, the right portal vein filled with the tumor thrombus without any tumor in liver parenchyma has been quite rare.

Erratum: Relation of MT1-MMP gene expression to outcomes in colorectal cancer

AMANE KANAZAWA, MD,* TAKASHI OSHIMA, MD, PhD, KAZUE YOSHIHARA, BA, SHUZO TAMURA, MD, TAKANOBU YAMADA, MD, DAISUKE INAGAKI, MD, TSUTOMU SATO, MD, NAOTO YAMAMOTO, MD, MANABU SHIOZAWA, MD, PhD, SOICHIRO MORINAGA, MD, PhD, MAKOTO AKAIKE, MD, PhD, CHIKARA KUNISAKI, MD, PhD, KATSUAKI TANAKA, MD, PhD, MUNETAKA MASUDA, MD, PhD, AND TOSHIO IMADA, MD, PhD Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Kanagawa-ken, Japan Gastroenterological Center, Yokohama City University Medical Center, Kanagawa-ken, Japan Department of Surgery, Yokohama City University, Kanagawa-ken, Japan Yokohama City University, Kanagawa-ken, Japan