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Dale A. Harcourt

DuPont

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Featured researches published by Dale A. Harcourt.

Bioorganic & Medicinal Chemistry Letters | 1995

Analogs of UK 14,304: Structural features responsible for α2 adrenoceptor activity

Stephen A. Munk; Dale A. Harcourt; P. Arasasingham; Charles Gluchowski; H. Wong; James E. Burke; Alexander B. Kharlamb; Cynthia A. Manlapaz; Edwin U. Padillo; L. Williams; Larry A. Wheeler; Michael E. Garst

Abstract Factors influencing the potency of UK 14,304 analogs including conformational preorganization and arrangement of hydrogen bond acceptors on the aromatic core are described. The previously reported importance of twist of the iminoimidazoline ring relative to the core for enhanced α 2 activity is supported.

Journal of the American Chemical Society | 1990

A new synthesis of substituted fulvenes

Gary C. M. Lee; Brian. Tobias; Judy M. Holmes; Dale A. Harcourt; Michael E. Garst

Archive | 1998

Substituted imidazole derivatives having agonist-like activity at alpha 2b or 2b/2c adrenergic receptors

Ken Chow; Daniel W. Gil; James A. Burke; Dale A. Harcourt; Michael E. Garst; Larry A. Wheeler; Stephen A. Munk

Archive | 2000

Compounds as selective agonists at alpha 2b or 2b/2c adrenergic receptors

Ken Chow; Daniel W. Gil; James A. Burke; Dale A. Harcourt; Michael E. Garst; Larry A. Wheeler; Stephen A. Munk

Archive | 2000

Methods of treating pain and other conditions

Ken Chow; Daniel W. Gil; James A. Burke; Dale A. Harcourt; Michael E. Garst; Larry A. Wheeler; Stephen A. Munk

Archive | 2002

Imidiazole derivatives and their use as agonists selective at alpha 2b or 2b/2c adrenergic receptors

Ken Chow; Daniel W. Gil; James A. Burke; Dale A. Harcourt; Michael E. Garst; Larry A. Wheeler; Stephen A. Munk; Dario G. Gomez

Archive | 2001

Imidiazoles having reduced side effects

Ken Chow; Daniel W. Gil; James A. Burke; Dale A. Harcourt; Michael E. Garst; Larry A. Wheeler; Stephen A. Munk; Dario G. Gomez; Todd M. Heidelbaugh

Journal of Organic Chemistry | 1991

Singlet oxygen oxidation of substituted furans to 5-hydroxy-2(5H)-furanone

Gary C. M. Lee; Elizabeth T. Syage; Dale A. Harcourt; Judy M. Holmes; Michael E. Garst

Journal of Medicinal Chemistry | 1997

Synthesis and evaluation of 2-(arylamino)imidazoles as α2-adrenergic agonists

Stephen A. Munk; Dale A. Harcourt; Premilla N. Arasasingham; James A. Burke; Alexander B. Kharlamb; Cynthia A. Manlapaz; Edwin U. Padillo; Donald Roberts; Eileen Runde; Linda Williams; Larry A. Wheeler; Michael E. Garst

Tetrahedron Letters | 1986

Total synthesis of manoalide

Michael E. Garst; Elizabeth A. Tallman; John N. Bonfiglio; Dale A. Harcourt; Eva B. Ljungwe; Anne Tran

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Michael E. Garst

University of California

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Stephen A. Munk

DuPont

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James A. Burke

DuPont

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Ken Chow

DuPont

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Daniel W. Gil

University of Arizona

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Larry A. Wheeler

Chiba University

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Charles Gluchowski

DuPont

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Larry A. Wheeler

Chiba University

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Alexander B. Kharlamb

DuPont

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Cynthia A. Manlapaz

DuPont

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