Dallas C. Mildenhall

The last glacial maximum in central and southern North Island, New Zealand: a paleoenvironmental reconstruction using the Kawakawa Tephra Formation as a chronostratigraphic marker

Abstract Kawakawa Tephra Formation, comprising Oruanui Ignimbrite flow member and Aokautere Ash airfall member, represents the products of an exceptionally large and widespread volcanic eruption from Taupo Volcanic Centre in the North Island of New Zealand. The eruption occurred during the Last Glacial Maximum, and is radiocarbon dated at c. 22.6 ka B.P. Thermoluminescence ages are in broad agreement with the radiocarbon age. The presence of Aokautere Ash in loess deposits, in alluvial gully-fills, on river terraces, and its absence from unstable sites, permits a detailed assessment of geomorphic activity during the Last Glacial Maximum. Widespread erosion of regolith, aggradation of river valleys, and deposition of loess, particularly in the period following eruption of the Kawakawa, point to a cold, dry, variable climate. A collation of pollen data for sediments containing Aokautere Ash, and those 14C dated in the range 17–23 ka, shows that tall forest was highly restricted in the central and southern parts of the North Island. An apparently subalpine grassland/shrubland was present at sites from present sea level to over 800 m elevation, suggesting that factors other than lower temperatures, such as exposure to wind and frost, fire and reduced rainfall, were important in controlling vegetation patterns. We conclude that the interval 23-13 ka B.P., broadly equivalent to oxygen isotope stage 2, represents the period of greatest environmental change in the North Island.

Poor quality vital anti-malarials in Africa - an urgent neglected public health priority

BackgroundPlasmodium falciparum malaria remains a major public health problem. A vital component of malaria control rests on the availability of good quality artemisinin-derivative based combination therapy (ACT) at the correct dose. However, there are increasing reports of poor quality anti-malarials in Africa.MethodsSeven collections of artemisinin derivative monotherapies, ACT and halofantrine anti-malarials of suspicious quality were collected in 2002/10 in eleven African countries and in Asia en route to Africa. Packaging, chemical composition (high performance liquid chromatography, direct ionization mass spectrometry, X-ray diffractometry, stable isotope analysis) and botanical investigations were performed.ResultsCounterfeit artesunate containing chloroquine, counterfeit dihydroartemisinin (DHA) containing paracetamol (acetaminophen), counterfeit DHA-piperaquine containing sildenafil, counterfeit artemether-lumefantrine containing pyrimethamine, counterfeit halofantrine containing artemisinin, and substandard/counterfeit or degraded artesunate and artesunate+amodiaquine in eight countries are described. Pollen analysis was consistent with manufacture of counterfeits in eastern Asia. These data do not allow estimation of the frequency of poor quality anti-malarials in Africa.ConclusionsCriminals are producing diverse harmful anti-malarial counterfeits with important public health consequences. The presence of artesunate monotherapy, substandard and/or degraded and counterfeit medicines containing sub-therapeutic amounts of unexpected anti-malarials will engender drug resistance. With the threatening spread of artemisinin resistance to Africa, much greater investment is required to ensure the quality of ACTs and removal of artemisinin monotherapies. The International Health Regulations may need to be invoked to counter these serious public health problems.

Paleoecological insights into subduction zone earthquake occurrence, eastern North Island, New Zealand

Paleoecological investigations of three Holocene marginal-marine sedimentary sequences provide information on vertical tectonic deformation in a transect across the forearc basin adjacent to the Hikurangi subduction zone, New Zealand. The elevation of maximum postglacial sea level indicators at Te Paeroa Lagoon and Opoho is between 4 and 6 m below present mean sea level, indicating net subsidence since 7200 yr B.P. Opoutama is closer to the Hikurangi Trench and appears to lie near the edge of the zone of subsidence, as evidence for vertical movement there is equivocal. Some of the subsidence at Te Paeroa Lagoon and Opoho is likely to be a result of compaction. However, a component of subsidence probably happened coseismically in two events at ca. 7100 and 5550 yr B.P. Event signatures consist of tsunami deposits overlain by chaotically mixed, reworked sediment that appears to have filled rapidly created accommodation space at marine inlet sites 10 km apart. Large offshore earthquakes are suggested by the coincidence of tsunami inundation with sudden subsidence. Forward elastic-dislocation models indicate that the observed subsidence could be achieved in ∼M w 7.9 earthquakes on either the subduction interface or the Lachlan Fault, which would involve synchronous uplift of Mahia Peninsula. Combined rupture of the interface and the Lachlan Fault, either simultaneously in a ∼M w 8.1 earthquake, or consecutively, could explain larger amounts (>1.5 m) of coastal subsidence.

Prokaryotic Populations and Activities in an Interbedded Coal Deposit, Including a Previously Deeply Buried Section (1.6–2.3 km) Above ∼ 150 Ma Basement Rock

A largely terrestrial, lignite/coal-bearing, 148 m core from the Waikato Basin, New Zealand, was studied, with a multidisciplinary approach, for subsurface microbiology. The top ≈76 m was Latest Miocene-Late Pleistocene (≈0.4–5.5 Ma) sediments, which overlay an unconformity and a previously deeply buried (1,600–2,300 m, × 55–75°C) ≈69 m section of moderately indurated, Late Eocene-Early Oligocene (≈32–35 Ma) deposits. Below this is weathered, Late Jurassic metasedimentary basement rock (145.5–157.0 Ma). Similar cell numbers (mean 1.2 × 106 cm −3 ), high viability (4–32%), intact phospholipids (biomarkers for living Bacteria) and activity (sulphate reduction, DNA replication) occurred heterogeneously throughout the core, including the weathered basement rock. Substantial numbers of viable anaerobic heterotrophic and lignite-utilizing bacteria (means 3.4 × 10 4 , 3.0 × 10 3 cm −3 ) were present throughout the core. This is similar to some deep terrestrial formations but contrasts with the generally exponentially decreasing prokaryotic populations in sub-seafloor sediments. For Bacteria, ≈76% of the 16S rRNA gene phylotypes were similar above (31.98 m) and below (133.55 m) the 76 m unconformity, which together with similar cell numbers indicates limited deep burial impact/palaeosterilization, or effective re-colonisation. Archaeal populations were not dominant being only detected with general primers at 31.98 m and those detected with methanogen functional primers were different above and below the ≈76 m unconformity. Both dominant bacterial (Proteobacteria, Actinobacteria, Firmicutes, Chloroflexi) and archaeal (Miscellaneous Crenarchaeotic Group, Methanosarcinales and Methanobacteriales) sequences were similar to those previously detected in both marine and terrestrial subsurface environments, reflecting the changing depositional conditions of the formation. However, the presence of ANME sequences had not been previously found in the terrestrial subsurface. A large proportion of the bacterial 16S rDNA diversity was cultured (43% of commonest genera). Prokaryotic populations and activity changed with lithology and depth and substrates (formate, acetate, oxalate) may diffuse from high-carbon, lignite/coaly layers to support bacterial populations in adjacent sandy or clay-silt layers.

New Zealand Eocene, Oligocene and Miocene Macrofossil and Pollen Records and Modern Plant Distributions in the Southern Hemisphere

The modern New Zealand flora has a relatively low number of families and genera in relation to land area, but well-preserved macrofossils and pollen from three sites in southern New Zealand suggest that the floras in Eocene, Oligocene and Miocene times were much more diverse at the generic level. At Pikopiko, Southland, a late Eocene in situ forest with fern understory was dominated by conifers, Casuarinaceae, Lauraceae, Nothofagus, Proteaceae, and mesothermal angiosperms including palms (aff. Calamus), Sapindaceae: Cupaniae and Picrodendraceae. At Newvale Mine, Southland, a leaf bed within a thick lignite seam represents leaf fossils preserved in a late Oligocene oligotrophic bog. This site demonstrates that Agathis, Dacrycarpus, Dacrydium, Halocarpus, Microcachrys, Podocarpus and Phyllocladus coexisted with diverse angiosperms including Nothofagus, Gymnostoma, Cunoniaceae, Ericaceae, Sapindaceae and several Proteaceae. Pollen data add Meliaceae, Myrtaceae, Onagraceae and Rubiaceae to the flora. At Foulden Maar, Otago, mummified leaves and flowers, including several with in situ pollen, demonstrate the existence of a diverse flora surrounding an Early Miocene lake. This site contains numerous monocot macrofossils including Astelia, Cordyline, Ripogonum and Typha, as well as the oldest fossils known for Orchidaceae and Luzuriagaceae. This flora was dominated by Lauraceae with affinities to Cryptocarya and Litsea, but other families include Araliaceae, Cunoniaceae, Elaeocarpaceae, Euphorbiaceae sensu lato, Menispermaceae, Myrsinaceae, Myrtaceae, Onagraceae, Proteaceae and Sterculiaceae. Many ferns, conifers, and Nothofagus are from lineages with Gondwanan ancestors, whereas other taxa show links to Australia (e.g., Gyrostemonaceae), New Caledonia (e.g., Beauprea) and South America (e.g., Luzuriaga, Fuchsia). Many of these taxa are now extinct in New Zealand, and therefore indicate much wider biogeographic ranges for many families and genera in the past.

Poor quality drugs: grand challenges in high throughput detection, countrywide sampling, and forensics in developing countries

Throughout history, poor quality medicines have been a persistent problem, with periodical crises in the supply of antimicrobials, such as fake cinchona bark in the 1600s and fake quinine in the 1800s. Regrettably, this problem seems to have grown in the last decade, especially afflicting unsuspecting patients and those seeking medicines via on-line pharmacies. Here we discuss some of the challenges related to the fight against poor quality drugs, and counterfeits in particular, with an emphasis on the analytical tools available, their relative performance, and the necessary workflows needed for distinguishing between genuine, substandard, degraded and counterfeit medicines.

Falsified medicines in Africa: all talk, no action

Fil: Newton, Paul N. . Mahosot Hospital. Microbiology Laboratory. Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit; Laos. Oxford University. Churchill Hospital. Nuffield Department of Medicine. Centre for Tropical Medicine and Global Health; Reino Unido. Oxford University. Churchill Hospital. Worldwide Antimalarial Resistance Network; Reino Unido

Orbitally-influenced vegetation record of the Mid-Pleistocene Climate Transition, offshore eastern New Zealand (ODP Leg 181, Site 1123)

A census of Plio–Pleistocene (5–0 Ma) terrestrial palynomorph assemblages from ODP Site 1123, located 1100 km offshore eastern New Zealand and in a water depth of 3290 m, reveals marked variations in warm- (Cyathea, tall tree Podocarpus/Prumnopitys, Dacrydium cupressinum) and cold- (Halocarpus, Phyllocladus, Nothofagus fusca type, Coprosma) climate indicator species at Milankovitch-scale periodicities. Time series analysis indicates that the vegetation record is covariant with marine climate proxies (carbonate content) and is strongly coherent at the 40-ka and 100-ka orbital frequency. A pronounced increase in amplitude and a coeval decrease in frequency of climate cycles from 40 to 100 ka occurs between 0.92 and 0.62 Ma, and provides a rare vegetation record of a fundamental reorganisation of Earth’s climate system – the Mid-Pleistocene Climate Transition. Despite the long distance from land and great water depth, terrestrial palynomorphs are relatively abundant in this high-resolution marine sediment record, where they reflect a southern North Island source. The predominance of robust spores and buoyant pollen (Cyathea, Podocarpus/Prumnopitys) indicates considerable current sorting and degradation of more delicate morphotypes during transport across the eastern North Island shelf. Little evidence is found for sorting and transport processes being significantly modulated by climate.

Fossil Ericaceae from New Zealand: deconstructing the use of fossil evidence in historical biogeography

The Australasian Ericaceae epitomize many problems in understanding the biogeography of the southern hemisphere, especially the relative contributions of Gondwanan vicariance and dispersal. Late Cretaceous fossil pollen of the family suggests extreme antiquity of the group in Australasia, but recent phylogenetic evidence suggests much younger histories for most of the groups in that region. This paper documents two new species of latest Oligocene-Early Miocene macrofossils of Ericaceae from New Zealand. Cyathodophyllum novae-zelandiae G.J.Jord. & Bannister gen. and sp. nov. is the oldest record of the tribe Styphelieae, but is of a clade now extinct in New Zealand, possibly related to the Tasmanian genus Cyathodes. Richeaphyllum waimumuensis G.J.Jord. & Bannister sp. nov. is a member of Richeeae, but it is ambiguous as to whether it is a member of the impressive modern New Zealand radiation in Dracophyllum. These fossils emphasize the fact that at least some of the fossil pollen of Ericaceae may have been derived from extinct lineages and therefore should not be used as evidence for the antiquity of any modern New Zealand clade of Ericaceae. New fossils and/or detailed analysis of fossil and extant pollen may help resolve such uncertainty.

Towards a record of Holocene tsunami and storms for northern Hawke's Bay, New Zealand

Abstract Eleven sand layers occur within Holocene low‐energy estuarine and marginal marine sequences of blue‐grey silty clay at two sites on the coastal plain between Wairoa and Mahia Peninsula, northern Hawkes Bay, New Zealand. The sedimentology and fossil assemblages of these layers are consistent with deposition by high‐energy influxes to the sites. Three influxes are terrestrial in nature and are thought to represent alluvial flood events. All other sand layers are marine derived and are likely to be the result of storm surges or tsunami. Tsunami inundation is favoured for two sand layers that occur in association with evidence for sudden subsidence at c. 6300 and c. 4800 yr BP The c. 6300 yr inundation also coincides with previously identified evidence for a tsunami at a site 10 km westwards along the coast. Further investigation is required to distinguish between tsunami and storm surge deposition for the remaining six layers.