Dalva Regina Neto Pimentel

Actinic cheilitis: histopathology and p53

Background:  Chronic actinic cheilitis (AC) is a precursor of squamous cell carcinoma (SCC) of the lip.

Treatment of recurrent aphthous stomatitis with clofazimine

OBJECTIVE The aim was to investigate the safety and efficacy of clofazimine for the treatment of recurrent aphthous stomatitis. STUDY DESIGN In this randomized controlled partially blind study, 23 patients received clofazimine 100 mg daily for 30 days and then 100 mg every other day. Twenty-three patients received colchicine 0.5 mg 3 times daily. Twenty patients received 1 placebo pill 2 times daily. All subjects received medications for 6 months. The chi-squared or Fisher exact tests were used to assess drug efficacy with respect to objective findings and symptoms. RESULTS A greater percentage of individuals in the clofazimine group had no further aphthous episodes (17%-44% compared with <or=6% in the other groups). A significantly greater percentage of treatment interruption occurred in the colchicine group because of gastrointestinal effects (23%-45%). Individuals in the clofazimine group who continued to suffer from aphthous stomatitis presented with better results for the evaluated variables. CONCLUSION Clofazimine should be considered for the treatment of recurrent aphthous stomatitis.

The oral mucosa in leprosy: a clinical and histopathological study

INTRODUCTION Multibacillary leprosy may involve the oral mucosa, with or without apparent lesions. There are few studies that deal with this issue in the era of multidrug therapy. AIM To assess the frequency of oral mucosa involvement in multibacillary leprosy patients. PATIENTS AND METHODS A transversal study with twenty non-treated multibacillary leprosy patients. The patients were treated in Dracena, São Paulo, between 2000 and 2002. Clinical examination of the oral mucosa was carried out. All patients were submitted to jugal mucosa, soft palate and tongue biopsies, in altered or in pre-established sites. The cross-sections were stained by techniques of hematoxilin-eosin and Ziehl-Neelsen. Granuloma and alcohol-acid-resistant bacilli findings determined the specific histopathological involvement. RESULTS The study involved 19 patients with an average of 2.5 years of disease progression. Specific histopathological involvement occurred in the tongue and soft palate of one lepromatous patient with an apparently normal oral mucosa. CONCLUSIONS (1) Clinical alterations in the oral mucosa does not imply disease involvement, it is necessary to have histopathological confirmation. (2) Apparent specific clinical alterations are rare. (3) The clinically normal oral mucosa can show specific histopathological involvement.

Actinic cheilitis adjacent to squamous carcinoma of the lips as an indicator of prognosis

UNLABELLED Many studies have shown an association between actinic cheilitis and squamous carcinoma of the lips. AIM The aim of the study was to observe the relation between actinic cheilitis and the prognosis of squamous carcinoma of the lips. MATERIALS AND METHODS This is a retrospective cross-sectional cohort study of squamous carcinoma of the lips. Histological sections of squamous carcinoma tumors done at the the Department of Pathology of the Sao Paulo Federal University between 1993 and 2000 were reviewed for evidence of actinic cheilitis in the lip vermillion adjacent to the tumor. Patient reports were reviewed to find information about exposure to sun, metastases and relapses. The occurrence or absence of relapses and metastases was correlated with the presence or absence of actinic cheilitis in the lip vermillion. Data was analyzed by Fishers Exact test. RESULTS Of the 31 selected patients, most were caucasian, males and with lower lip involvement. Statistical analysis demonstrated independence between the occurrence of metastases and relapse and gender, skin color and site (lower or upper lips). There was dependence between actinic cheilitis and solar elastosis, and between the absence of actinic cheilitis and the occurrence of metastases. There was no dependence between the absence of actinic cheilitis and the occurrence of relapses. CONCLUSION It may be concluded that tumors originating from actinic cheilitis have a better prognosis.

Granular parakeratosis in children: case report and review of the literature.

Abstract: Granular parakeratosis is a cutaneous eruption with erythematous and/or brownish hyperkeratotic papules and plaques which are exclusively localized to intertriginous areas and show histopathologic features of an unusual form of parakeratosis. The etiology is unknown, but the excessive use of various topical preparations (e.g., ointments and deodorants) has been associated with this disease. It has heretofore been reported only in adults. We report two children, ages 3 and 5 months, with characteristic lesions in the groin associated with topical pomades used to prevent diaper rash. This is the first report associating the clinical presentation and the histopathologic diagnosis of granular parakeratosis in children. The literature on this entity is also reviewed and all case reports are summarized.

A mucosa oral na hanseníase: um estudo clínico e histopatológico

INTRODUCAO: a anseniase multibacilar pode causar comprometimento da mucosa oral, com ou sem lesoes aparentes. Ha poucos estudos que tratam deste assunto na era da multidrogaterapia. OBJETIVO: Verificar a frequencia do comprometimento da mucosa oral em pacientes de hanseniase multibacilar. CASUISTICA E METODOS: Foi realizado um estudo transversal em vinte pacientes de hanseniase multibacilar, nao-tratados, atendidos consecutivamente em Dracena, Sao Paulo, entre o periodo de 2000 e 2002. Foi realizado exame clinico completo da mucosa oral. Os pacientes foram submetidos a biopsias na mucosa jugal, na lingua e no palato mole, em alteracao ou em pontos pre-estabelecidos. Os cortes foram corados pelas tecnicas da hematoxilina-eosina e Ziehl-Neelsen. O encontro de granuloma e bacilos alcool-acido-resistentes ao exame histopatologico determinou o comprometimento especifico. RESULTADOS: O estudo envolveu 19 pacientes multibacilares com tempo medio de evolucao de 2,5 anos. Ocorreu comprometimento histopatologico especifico em apenas um paciente virchowiano, com mucosa oral clinicamente normal, na lingua e no palato mole. CONCLUSOES: 1. Alteracao clinica na mucosa oral nao implica em comprometimento pela doenca, e necessario confirmacao histopatologica. 2. Alteracoes clinicas especificas aparentes sao raras. 3. A mucosa oral clinicamente normal pode exibir comprometimento histopatologico especifico.

Presence of oral lesions in leprosy patients does not imply involvement by Mycobacterium leprae

6. Huang GT-J, Yamaza T, Shea L, Djouad F, Kuhn N, Tuan R, Shi S. Stem/progenitor cell–mediated de novo regeneration of dental pulp with newly deposited continuous layer of dentin in an in vivo model. Tissue Eng A. Epub ahead of print November 19, 2009. 7. Huang GT-J, Gronthos S, Shi S. Mesenchymal stem cells derived from dental tissues vs. those from other sources: their biology and role in regenerative medicine. J Dent Res 2009;88:792-806.