Damir Gugić
Josip Juraj Strossmayer University of Osijek
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Publication
Featured researches published by Damir Gugić.
Pathology Research and Practice | 2017
Jasmina Rajc; Damir Gugić; Irena Fröhlich; Ksenija Marjanović; Boris Dumenčić
Nectins are Ca2+-independent immunoglobulin (Ig) superfamily proteins that participate in the organization of epithelial and endothelial junctions and regulate several cellular activities including the entry of some viruses. Nectin-4 has recently been shown as a metastasis-associated protein in several cancers. In the following study, we have evaluated the expression of Nectin-4 inthe luminal B HER2 negative subtype breast cancer. The study group consisted of 147 patients presenting with primary unilateral breast carcinoma with no evidence of distant metastases. Nectin-4 protein expression was assessed by immunohistochemistry and the results were correlated with the clinical data using Kaplan-Meier curves, univariate and multivariate stepwise proportional-hazard analysis (Cox model). Nectin-4 overexpression was significantly correlated with the tumour size (p<0.05; Fishers Exact Test), also Nectin-4 expression was negatively associated with overall survival, disease free survival and distant relapse free survival with the same significance (p<0,001; Kaplan-Meier, Cox model). We did not find statistically significant correlation between Nectin-4 and age, ER, PR, age, lymph node metastasis, tumour differentiation, histologicalsubtype and Ki-67proliferation index. We suggest that Nectin-4 is a relevant prognostic factor and a therapeutic target in luminalB (HER2 negative) breast cancer.
Acta Clinica Croatica | 2017
Josipa Flam; Damir Gugić; Mirta Benšić; Snježana Tomić; Jasmina Rajc
High stroma proportion appears to be a very important prognostic factor in esophageal and breast cancer. Previous researches have shown that it might have a similar effect on colorectal cancer. The aim of this study was to determine whether tumor stroma proportion influenced patient survival. This retrospective study included 236 patients with colorectal cancer having undergone surgery in 2006 and 2007 at Osijek University Hospital Center. Location with the highest stroma proportion at the site of deepest tumor invasion was determined. Patients were divided into the groups with high stroma proportion (>50%) and low stroma proportion (≤50%). Stroma proportion showed a statistically significant correlation with tumor stage. Kaplan-Meier survival curves yielded a statistically significant difference in patient overall survival (Cox ph model p=0.016) and progression-free survival (Cox ph model, p=0.0188) according to stroma proportion. Study results showed a statistically significantly shorter overall survival and progression-free survival in patients with high stroma proportion.
The Breast | 2017
Lidija Bošković; Maja Gašparić; Marija Petković; Damir Gugić; Ingrid Belac Lovasić; Željko Soldić; Branka Petrić Miše; Nina Dabelić; Ljubica Vazdar; Eduard Vrdoljak
European Journal of Cancer | 2015
Eduard Vrdoljak; Z. Soldic; Maja Gašparić; Lidija Bošković; I. Belac Lovasic; Nina Dabelić; Damir Gugić; D. Ledina; M. Bozic Sakic; Z. Raspovic; R. Zorica; D. Trivanovic; Marija Petković
Lijec̆nic̆ki vjesnik | 2012
Rudolf Tomek; Lidija Beketić Orešković; Eduard Vrdoljak; Soldić Z; Paula Podolski; Stjepko Pleština; Damir Gugić; Vojnović Z; Branka Petrić Miše; Snježana Tomić; Josip Fajdić; Danko Velimir Vrdoljak; Ivo Drinković; Boris Brkljačić; Elvira Mustać
Lijec̆nic̆ki vjesnik | 2011
Samarzija M; Damir Gugić; Jelena Radić; Eduard Vrdoljak; Marko Jakopovic; Marijo Boban; Ingrid Belac Lovasić; Nabil Chalfe; Sanja Pleština; Zoran Slobodnjak; Jezek Ss; Nives Jonjić; Kukuljan M
Lijec̆nic̆ki vjesnik | 2009
Rudolf Tomek; Eduard Vrdoljak; Damir Vrbanec; Damir Nemet; Višnja Matković; Stjepko Pleština; Damir Gugić; Renata Dobrila Dintinjana; Ante Bolanča; Miro Samardžija; Marija Petković
Collegium Antropologicum | 2003
Josip Fajdić; Damir Buković; Mladen Belicza; Mario Habek; Damir Gugić; Iva Hojsak; Hrvoje Silovski; Anđelina Bokić
Collegium Antropologicum | 2003
Josip Fajdić; Damir Buković; Damir Gugić; Mario Habek; Iva Hojsak; Nevija Buković; Ivan Herman; Tajana Stančerić
Archive | 2018
Eduard Vrdoljak; Ingrid Belac Lovasić; Zvonko Kusić; Damir Gugić; Antonio Juretić; Marija Ban; Joško Bezić; Marijo Boban; Tihana Boraska Jelavić; Lidija Bošković; Liana Cambj Sapunar; Darijo Hrepić; Inga Marjanović; Tomislav Omrčen; Branka Petrić Miše; Boris Ružić; Ante Strikić; Ivan Šamija; Snježana Tomić; Jelena Viculin