Dandu R Reddy

A simple synthetic protocol for the protection of amides, lactams, ureas, and carbamates

Abstract A new procedure for protecting the amide, lactam, urea, and carbamate NH group with a triphenylmethyl (Tr) group is described. The utility of this method is illustrated with molecules that contain other functional groups. A mild deprotection using trifluoroacetic acid makes this a useful method for attaching amide groups on resin for combinatorial synthesis.

Construction of a kinase inhibitor library via parallel synthesis

A modified core structure of indolo[2,3-a]carbazole template has been immobilized. EtMgBr was identified as a substrate compatible base providing solid-phase dianion formation. Depending upon the nature of the electrophile, the core structure has been selectively functionalized to generate a library of kinase inhibitors.