Dang Sheng-chun

EphB4 is overexpressed in papillary thyroid carcinoma and promotes the migration of papillary thyroid cancer cells

EphB4 tyrosine kinase receptor has been involved in various physiologic and pathologic processes, and the role of the EphB4 in tumorigenesis has recently attracted much interest. However, its function in papillary thyroid carcinoma remains poorly understood. In this study, we explored the function of EphB4 in papillary thyroid carcinoma. We found that the expression of EphB4 was significantly upregulated in clinical samples. Overexpression of EphB4 in papillary thyroid carcinoma cell lines accelerated cell migration. In contrast, downregulation of EphB4 inhibited cell migration and suppressed in vivo tumor metastasis. Furthermore, we showed that EphB4 promoted cell migration by inhibiting the phosphorylation of FAK and paxillin. Moreover, EphB4 promoted cell migration in a kinase-independent manner. Taken together, our findings suggest that EphB4 plays an important role in the progression of papillary thyroid carcinoma by stimulating cell migration and EphB4 might be a potential therapeutic target in papillary thyroid carcinoma.

YEATS4 promotes the tumorigenesis of pancreatic cancer by activating beta-catenin/TCF signaling

Beta-catenin/TCF signaling has been reported to promote the growth and metastasis of pancreatic cancer cells. However, the regulation for the beta-catenin/TCF transcriptional complex remains largely unknown. Here, we have found that YEATS4 is a positive regulator for Beta-catenin/TCF signaling. The expression of YEATS4 was elevated in clinical pancreatic cancer samples and pancreatic cancer mouse model. Up-regulation of YEATS4 promoted the growth, migration and invasion of pancreatic cancer cells, while knocking down the expression of YEATS4 inhibited the growth, migration, invasion and metastasis of pancreatic cancer cells. Moreover, the mechanism study revealed that YEATS4 interacted with beta-catenin and activated beta-catenin/TCF signaling. Furthermore, knocking down the expression of YEATS4 impaired the malignant transformation of normal pancreatic cells (HPDE6C7) by the oncogenic Ras. Taken together, our study demonstrated the oncogenic roles of YEATS4 in the progression of pancreatic cancer by activating beta-catenin/TCF signaling and suggested that YEATS4 might be a promising therapeutic target for pancreatic cancer.

Subtotal Thyroidectomy with Anomalous Innominate Artery

I. Background The clinical entity of an anomalous innominate artery constricting the trachea and causing respiratory symptoms stayed first recognized through Gross and Neuhauser in 1948. In clinical its always find this anomaly, as it can be an incidental finding in asymptomatic .Vascular rings be present uncommon congenital anomalies from an embryological disorder of the combined aortic arches or branching pulmonary arteries. Uncommon congenital anomalies that present with upper airway obstruction . The physical findings and symptoms formed by vascular rings are correlated to the structure(s) they circumscribe both trachea, esophagus, for the confirm diagnosis computed tomography (CT), X-ray, angiography or magnetic resonance imaging (MRI) are used and also for surgical planning. The diagnostic modalities, surgical treatment as well as outcome surely discussed. We report a case of a innominate artery extends to the level of the thyroid. This anomaly is relatively rare, understanding of this anomaly can avoid catastrophic bleeding or other complications of potential, is very necessary.