Daniel A. Benigni

Preparation of the geometric isomers of DDC, DDA, D4C and D4T as potential anti-HIV agents

Abstract β-L-ddC ( 5 ), β-L-ddA ( 7 ), β-L-d4T ( 7 ) and β-L-d4C ( 8 ) (enantiomers of natural dideoxynucleoside analogues with known potent HIV activity) were prepared as potential anti-HIV agents.

Palladium-catalyzed coupling between cephalosporin derivatives and unsaturated stannanes: A new ligand for palladium chemistry

Abstract We describe a general coupling procedure between 3-chloromethylcephems and unsaturated stannanes that employs a palladium catalyst featuring the new ligand tri(2-furyl)phosphine.

A new synthesis of 2′,3′-dideoxynucleosides for aids chemotherapy

Abstract Dideoxynucleosides were prepared in high optical purity from L-glutamic acid. The condensation reactions between activated 2,3-dideoxypentofuranoses and silylated purines or pyrimidines afforded separable β/α mixtures of dideoxynucleosides.